Modelling Parkinson’s Disease: iPSCs towards Better Understanding of Human Pathology
Parkinson’s Disease (PD) is a chronic neurodegenerative disorder characterized by motor and non-motor symptoms, among which are bradykinesia, rigidity, tremor as well as mental symptoms such as dementia. The underlying cause of Parkinson disease is degeneration of dopaminergic neurons. It has been c...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/11/3/373 |
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| author | Sahar Avazzadeh Jara Maria Baena Cameron Keighron Yajaira Feller-Sanchez Leo R. Quinlan |
| author_facet | Sahar Avazzadeh Jara Maria Baena Cameron Keighron Yajaira Feller-Sanchez Leo R. Quinlan |
| author_sort | Sahar Avazzadeh |
| collection | DOAJ |
| description | Parkinson’s Disease (PD) is a chronic neurodegenerative disorder characterized by motor and non-motor symptoms, among which are bradykinesia, rigidity, tremor as well as mental symptoms such as dementia. The underlying cause of Parkinson disease is degeneration of dopaminergic neurons. It has been challenging to develop an efficient animal model to accurately represent the complex phenotypes found with PD. However, it has become possible to recapitulate the myriad of phenotypes underlying the PD pathology by using human induced pluripotent stem cell (iPSC) technology. Patient-specific iPSC-derived dopaminergic neurons are available and present an opportunity to study many aspects of the PD phenotypes in a dish. In this review, we report the available data on iPSC-derived neurons derived from PD patients with identified gene mutations. Specifically, we will report on the key phenotypes of the generated iPSC-derived neurons from PD patients with different genetic background. Furthermore, we discuss the relationship these cellular phenotypes have to PD pathology and future challenges and prospects for iPSC modelling and understanding of the pathogenesis of PD. |
| first_indexed | 2024-03-10T13:14:27Z |
| format | Article |
| id | doaj.art-605802c2b72844fa9e575786bfa0db96 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T13:14:27Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-605802c2b72844fa9e575786bfa0db962023-11-21T10:29:08ZengMDPI AGBrain Sciences2076-34252021-03-0111337310.3390/brainsci11030373Modelling Parkinson’s Disease: iPSCs towards Better Understanding of Human PathologySahar Avazzadeh0Jara Maria Baena1Cameron Keighron2Yajaira Feller-Sanchez3Leo R. Quinlan4Physiology and CÚRAM SFI Centre for Research in Medical Devices, School of Medicine, National University of Ireland (NUI), H91 TK33 Galway, IrelandPhysiology and CÚRAM SFI Centre for Research in Medical Devices, School of Medicine, National University of Ireland (NUI), H91 TK33 Galway, IrelandPhysiology and CÚRAM SFI Centre for Research in Medical Devices, School of Medicine, National University of Ireland (NUI), H91 TK33 Galway, IrelandPhysiology and CÚRAM SFI Centre for Research in Medical Devices, School of Medicine, National University of Ireland (NUI), H91 TK33 Galway, IrelandPhysiology and CÚRAM SFI Centre for Research in Medical Devices, School of Medicine, National University of Ireland (NUI), H91 TK33 Galway, IrelandParkinson’s Disease (PD) is a chronic neurodegenerative disorder characterized by motor and non-motor symptoms, among which are bradykinesia, rigidity, tremor as well as mental symptoms such as dementia. The underlying cause of Parkinson disease is degeneration of dopaminergic neurons. It has been challenging to develop an efficient animal model to accurately represent the complex phenotypes found with PD. However, it has become possible to recapitulate the myriad of phenotypes underlying the PD pathology by using human induced pluripotent stem cell (iPSC) technology. Patient-specific iPSC-derived dopaminergic neurons are available and present an opportunity to study many aspects of the PD phenotypes in a dish. In this review, we report the available data on iPSC-derived neurons derived from PD patients with identified gene mutations. Specifically, we will report on the key phenotypes of the generated iPSC-derived neurons from PD patients with different genetic background. Furthermore, we discuss the relationship these cellular phenotypes have to PD pathology and future challenges and prospects for iPSC modelling and understanding of the pathogenesis of PD.https://www.mdpi.com/2076-3425/11/3/373Parkinson’s diseaseinduced pluripotent stem cellshuman pathology |
| spellingShingle | Sahar Avazzadeh Jara Maria Baena Cameron Keighron Yajaira Feller-Sanchez Leo R. Quinlan Modelling Parkinson’s Disease: iPSCs towards Better Understanding of Human Pathology Brain Sciences Parkinson’s disease induced pluripotent stem cells human pathology |
| title | Modelling Parkinson’s Disease: iPSCs towards Better Understanding of Human Pathology |
| title_full | Modelling Parkinson’s Disease: iPSCs towards Better Understanding of Human Pathology |
| title_fullStr | Modelling Parkinson’s Disease: iPSCs towards Better Understanding of Human Pathology |
| title_full_unstemmed | Modelling Parkinson’s Disease: iPSCs towards Better Understanding of Human Pathology |
| title_short | Modelling Parkinson’s Disease: iPSCs towards Better Understanding of Human Pathology |
| title_sort | modelling parkinson s disease ipscs towards better understanding of human pathology |
| topic | Parkinson’s disease induced pluripotent stem cells human pathology |
| url | https://www.mdpi.com/2076-3425/11/3/373 |
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