Expanding the MAPPs Assay to Accommodate MHC-II Pan Receptors for Improved Predictability of Potential T Cell Epitopes

Expanding the MAPPs Assay to Accommodate MHC-II Pan Receptors for Improved Predictability of Potential T Cell Epitopes

A critical step in the immunogenicity cascade is attributed to human leukocyte antigen (HLA) II presentation triggering T cell immune responses. The liquid chromatography–tandem mass spectrometry (LC-MS/MS)-based major histocompatibility complex (MHC) II-associated peptide proteomics (MAPPs) assay i...

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Bibliographic Details
Main Authors: Katharina Hartman, Guido Steiner, Michel Siegel, Cary M. Looney, Timothy P. Hickling, Katharine Bray-French, Sebastian Springer, Céline Marban-Doran, Axel Ducret
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Biology
Subjects:
anti-drug antibody
immunogenicity
<i>in silico</i> analysis
MAPPs assay
mass spectrometry
HLA II receptors
Online Access:https://www.mdpi.com/2079-7737/12/9/1265

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