LAT1 acts as a crucial transporter of amino acids in human thymic carcinoma cells
L-type amino acid transporter 1 (LAT1, SLC7A5) incorporates essential amino acids into cells. Recent studies have shown that LAT1 is a predominant transporter in various human cancers. However, the function of LAT1 in thymic carcinoma remains unknown. Here we demonstrate that LAT1 is a critical tran...
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| Format: | Article |
| Language: | English |
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Elsevier
2016-11-01
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| Series: | Journal of Pharmacological Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861316300883 |
| _version_ | 1818249753720258560 |
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| author | Keitaro Hayashi Promsuk Jutabha Sumiko Maeda Yothaisong Supak Motoshi Ouchi Hitoshi Endou Tomoe Fujita Masayuki Chida Naohiko Anzai |
| author_facet | Keitaro Hayashi Promsuk Jutabha Sumiko Maeda Yothaisong Supak Motoshi Ouchi Hitoshi Endou Tomoe Fujita Masayuki Chida Naohiko Anzai |
| author_sort | Keitaro Hayashi |
| collection | DOAJ |
| description | L-type amino acid transporter 1 (LAT1, SLC7A5) incorporates essential amino acids into cells. Recent studies have shown that LAT1 is a predominant transporter in various human cancers. However, the function of LAT1 in thymic carcinoma remains unknown. Here we demonstrate that LAT1 is a critical transporter for human thymic carcinoma cells. LAT1 was strongly expressed in human thymic carcinoma tissues. LAT1-specific inhibitor significantly suppressed leucine uptake and growth of Ty82 human thymic carcinoma cell lines, suggesting that thymic carcinoma takes advantage of LAT1 as a quality transporter and that LAT1-specific inhibitor might be clinically beneficial in therapy for thymic carcinoma. |
| first_indexed | 2024-12-12T15:41:30Z |
| format | Article |
| id | doaj.art-6058706be7b249baabd7f8730bb9aec4 |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-12-12T15:41:30Z |
| publishDate | 2016-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-6058706be7b249baabd7f8730bb9aec42022-12-22T00:19:53ZengElsevierJournal of Pharmacological Sciences1347-86132016-11-01132320120410.1016/j.jphs.2016.07.006LAT1 acts as a crucial transporter of amino acids in human thymic carcinoma cellsKeitaro Hayashi0Promsuk Jutabha1Sumiko Maeda2Yothaisong Supak3Motoshi Ouchi4Hitoshi Endou5Tomoe Fujita6Masayuki Chida7Naohiko Anzai8Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Shimotsuga, Tochigi 321-0293, JapanDepartment of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Shimotsuga, Tochigi 321-0293, JapanDepartment of General Thoracic Surgery, Dokkyo Medical University School of Medicine, Shimotsuga, Tochigi 321-0293, JapanDepartment of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Shimotsuga, Tochigi 321-0293, JapanDepartment of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Shimotsuga, Tochigi 321-0293, JapanJ-Pharma Co., Ltd., Yokohama, Kanagawa 230-0046, JapanDepartment of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Shimotsuga, Tochigi 321-0293, JapanDepartment of General Thoracic Surgery, Dokkyo Medical University School of Medicine, Shimotsuga, Tochigi 321-0293, JapanDepartment of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Shimotsuga, Tochigi 321-0293, JapanL-type amino acid transporter 1 (LAT1, SLC7A5) incorporates essential amino acids into cells. Recent studies have shown that LAT1 is a predominant transporter in various human cancers. However, the function of LAT1 in thymic carcinoma remains unknown. Here we demonstrate that LAT1 is a critical transporter for human thymic carcinoma cells. LAT1 was strongly expressed in human thymic carcinoma tissues. LAT1-specific inhibitor significantly suppressed leucine uptake and growth of Ty82 human thymic carcinoma cell lines, suggesting that thymic carcinoma takes advantage of LAT1 as a quality transporter and that LAT1-specific inhibitor might be clinically beneficial in therapy for thymic carcinoma.http://www.sciencedirect.com/science/article/pii/S1347861316300883Thymic carcinomaAnticancer drugTransporter |
| spellingShingle | Keitaro Hayashi Promsuk Jutabha Sumiko Maeda Yothaisong Supak Motoshi Ouchi Hitoshi Endou Tomoe Fujita Masayuki Chida Naohiko Anzai LAT1 acts as a crucial transporter of amino acids in human thymic carcinoma cells Journal of Pharmacological Sciences Thymic carcinoma Anticancer drug Transporter |
| title | LAT1 acts as a crucial transporter of amino acids in human thymic carcinoma cells |
| title_full | LAT1 acts as a crucial transporter of amino acids in human thymic carcinoma cells |
| title_fullStr | LAT1 acts as a crucial transporter of amino acids in human thymic carcinoma cells |
| title_full_unstemmed | LAT1 acts as a crucial transporter of amino acids in human thymic carcinoma cells |
| title_short | LAT1 acts as a crucial transporter of amino acids in human thymic carcinoma cells |
| title_sort | lat1 acts as a crucial transporter of amino acids in human thymic carcinoma cells |
| topic | Thymic carcinoma Anticancer drug Transporter |
| url | http://www.sciencedirect.com/science/article/pii/S1347861316300883 |
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