Cu(I)/Pd(II)-Catalyzed Intramolecular Hydroamidation and C-H Dehydrogenative Coupling of <i>ortho</i>-Alkynyl-<i>N</i>-arylbenzamides for Access to Isoindolo[2,1-<i>a</i>]Indol-6-Ones
An efficient, atom-economic and one-pot synthesis of isoindolo[2,1-<i>a</i>]indol-6-ones via CuI/Pd(OAc)<sub>2</sub>-catalyzed intramolecular hydroamidation of alkynyl group, and C-H dehydrogenative coupling of <i>ortho</i>-alkynyl-<i>N</i>-arylbenzami...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-05-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/27/11/3393 |
| Summary: | An efficient, atom-economic and one-pot synthesis of isoindolo[2,1-<i>a</i>]indol-6-ones via CuI/Pd(OAc)<sub>2</sub>-catalyzed intramolecular hydroamidation of alkynyl group, and C-H dehydrogenative coupling of <i>ortho</i>-alkynyl-<i>N</i>-arylbenzamides has been developed. This transformation occurs with the use of oxygen as the oxidant, and water is the only by-product. The reaction shows a high tolerance to a variety of functional groups, and affords isoindolo[2,1-<i>a</i>]indol-6-ones in good to high yields. |
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| ISSN: | 1420-3049 |