Genomics of circadian rhythms in health and disease
Abstract Circadian clocks are endogenous oscillators that control 24-h physiological and behavioral processes. The central circadian clock exerts control over myriad aspects of mammalian physiology, including the regulation of sleep, metabolism, and the immune system. Here, we review advances in und...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMC
2019-12-01
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| Series: | Genome Medicine |
| Online Access: | https://doi.org/10.1186/s13073-019-0704-0 |
| _version_ | 1818952350334713856 |
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| author | Filipa Rijo-Ferreira Joseph S. Takahashi |
| author_facet | Filipa Rijo-Ferreira Joseph S. Takahashi |
| author_sort | Filipa Rijo-Ferreira |
| collection | DOAJ |
| description | Abstract Circadian clocks are endogenous oscillators that control 24-h physiological and behavioral processes. The central circadian clock exerts control over myriad aspects of mammalian physiology, including the regulation of sleep, metabolism, and the immune system. Here, we review advances in understanding the genetic regulation of sleep through the circadian system, as well as the impact of dysregulated gene expression on metabolic function. We also review recent studies that have begun to unravel the circadian clock’s role in controlling the cardiovascular and nervous systems, gut microbiota, cancer, and aging. Such circadian control of these systems relies, in part, on transcriptional regulation, with recent evidence for genome-wide regulation of the clock through circadian chromosome organization. These novel insights into the genomic regulation of human physiology provide opportunities for the discovery of improved treatment strategies and new understanding of the biological underpinnings of human disease. |
| first_indexed | 2024-12-20T09:48:59Z |
| format | Article |
| id | doaj.art-605c07609d3e4420a35facf941a568fa |
| institution | Directory Open Access Journal |
| issn | 1756-994X |
| language | English |
| last_indexed | 2024-12-20T09:48:59Z |
| publishDate | 2019-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Genome Medicine |
| spelling | doaj.art-605c07609d3e4420a35facf941a568fa2022-12-21T19:44:39ZengBMCGenome Medicine1756-994X2019-12-0111111610.1186/s13073-019-0704-0Genomics of circadian rhythms in health and diseaseFilipa Rijo-Ferreira0Joseph S. Takahashi1Department of Neuroscience, University of Texas Southwestern Medical CenterDepartment of Neuroscience, University of Texas Southwestern Medical CenterAbstract Circadian clocks are endogenous oscillators that control 24-h physiological and behavioral processes. The central circadian clock exerts control over myriad aspects of mammalian physiology, including the regulation of sleep, metabolism, and the immune system. Here, we review advances in understanding the genetic regulation of sleep through the circadian system, as well as the impact of dysregulated gene expression on metabolic function. We also review recent studies that have begun to unravel the circadian clock’s role in controlling the cardiovascular and nervous systems, gut microbiota, cancer, and aging. Such circadian control of these systems relies, in part, on transcriptional regulation, with recent evidence for genome-wide regulation of the clock through circadian chromosome organization. These novel insights into the genomic regulation of human physiology provide opportunities for the discovery of improved treatment strategies and new understanding of the biological underpinnings of human disease.https://doi.org/10.1186/s13073-019-0704-0 |
| spellingShingle | Filipa Rijo-Ferreira Joseph S. Takahashi Genomics of circadian rhythms in health and disease Genome Medicine |
| title | Genomics of circadian rhythms in health and disease |
| title_full | Genomics of circadian rhythms in health and disease |
| title_fullStr | Genomics of circadian rhythms in health and disease |
| title_full_unstemmed | Genomics of circadian rhythms in health and disease |
| title_short | Genomics of circadian rhythms in health and disease |
| title_sort | genomics of circadian rhythms in health and disease |
| url | https://doi.org/10.1186/s13073-019-0704-0 |
| work_keys_str_mv | AT filiparijoferreira genomicsofcircadianrhythmsinhealthanddisease AT josephstakahashi genomicsofcircadianrhythmsinhealthanddisease |