A Stable Open-Shell Conjugated Diradical Polymer with Ultra-High Photothermal Conversion Efficiency for NIR-II Photo-Immunotherapy of Metastatic Tumor

A Stable Open-Shell Conjugated Diradical Polymer with Ultra-High Photothermal Conversion Efficiency for NIR-II Photo-Immunotherapy of Metastatic Tumor

Highlights By employing side-chain regulation, the photothermal therapy response of conjugated diradical polymer can red-shift from near-infrared (NIR)-I to the NIR-II region. This strategy offers new radical materials in developing NIR-II photothermal materials. The conjugated diradical polymer TTB...

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Bibliographic Details
Main Authors: Yijian Gao, Ying Liu, Xiliang Li, Hui Wang, Yuliang Yang, Yu Luo, Yingpeng Wan, Chun-sing Lee, Shengliang Li, Xiao-Hong Zhang
Format: Article
Language:English
Published: SpringerOpen 2023-11-01
Series:Nano-Micro Letters
Subjects:
NIR-II conjugated polymer
Photothermal
Radical
Nanoparticles
Cancer therapy
Online Access:https://doi.org/10.1007/s40820-023-01219-x
Description
Summary:Highlights By employing side-chain regulation, the photothermal therapy response of conjugated diradical polymer can red-shift from near-infrared (NIR)-I to the NIR-II region. This strategy offers new radical materials in developing NIR-II photothermal materials. The conjugated diradical polymer TTB-2 receives a record-high photothermal conversion efficiency of 87.7%, far beyond the recently reported NIR-II photothermal agents. Such conjugated diradical polymer must enrich the NIR-II photothermal agents’ library and provide important insight for more diradical polymer construction. The conjugated diradical polymer nanoparticles TTB-2 NPs achieve good tumor photoablation with navigation of photoacoustic imaging in the NIR-II window, without any side effect. Furthermore, the efficient photo-immunity effect prevents the pulmonary metastasis of breast cancer.
ISSN:2311-6706
2150-5551

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