A Stable Open-Shell Conjugated Diradical Polymer with Ultra-High Photothermal Conversion Efficiency for NIR-II Photo-Immunotherapy of Metastatic Tumor
Highlights By employing side-chain regulation, the photothermal therapy response of conjugated diradical polymer can red-shift from near-infrared (NIR)-I to the NIR-II region. This strategy offers new radical materials in developing NIR-II photothermal materials. The conjugated diradical polymer TTB...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2023-11-01
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| Series: | Nano-Micro Letters |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s40820-023-01219-x |
| _version_ | 1797451757406650368 |
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| author | Yijian Gao Ying Liu Xiliang Li Hui Wang Yuliang Yang Yu Luo Yingpeng Wan Chun-sing Lee Shengliang Li Xiao-Hong Zhang |
| author_facet | Yijian Gao Ying Liu Xiliang Li Hui Wang Yuliang Yang Yu Luo Yingpeng Wan Chun-sing Lee Shengliang Li Xiao-Hong Zhang |
| author_sort | Yijian Gao |
| collection | DOAJ |
| description | Highlights By employing side-chain regulation, the photothermal therapy response of conjugated diradical polymer can red-shift from near-infrared (NIR)-I to the NIR-II region. This strategy offers new radical materials in developing NIR-II photothermal materials. The conjugated diradical polymer TTB-2 receives a record-high photothermal conversion efficiency of 87.7%, far beyond the recently reported NIR-II photothermal agents. Such conjugated diradical polymer must enrich the NIR-II photothermal agents’ library and provide important insight for more diradical polymer construction. The conjugated diradical polymer nanoparticles TTB-2 NPs achieve good tumor photoablation with navigation of photoacoustic imaging in the NIR-II window, without any side effect. Furthermore, the efficient photo-immunity effect prevents the pulmonary metastasis of breast cancer. |
| first_indexed | 2024-03-09T14:59:00Z |
| format | Article |
| id | doaj.art-605c29bc05ef43f8a338888035d9f0d0 |
| institution | Directory Open Access Journal |
| issn | 2311-6706 2150-5551 |
| language | English |
| last_indexed | 2024-03-09T14:59:00Z |
| publishDate | 2023-11-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Nano-Micro Letters |
| spelling | doaj.art-605c29bc05ef43f8a338888035d9f0d02023-11-26T14:01:00ZengSpringerOpenNano-Micro Letters2311-67062150-55512023-11-0116111410.1007/s40820-023-01219-xA Stable Open-Shell Conjugated Diradical Polymer with Ultra-High Photothermal Conversion Efficiency for NIR-II Photo-Immunotherapy of Metastatic TumorYijian Gao0Ying Liu1Xiliang Li2Hui Wang3Yuliang Yang4Yu Luo5Yingpeng Wan6Chun-sing Lee7Shengliang Li8Xiao-Hong Zhang9College of Pharmaceutical Sciences, Soochow UniversityCollege of Pharmaceutical Sciences, Soochow UniversityCollege of Pharmaceutical Sciences, Soochow UniversityInstitute of Functional Nano & Soft Materials (FUNSOM), Soochow UniversityCollege of Pharmaceutical Sciences, Soochow UniversityCollege of Pharmaceutical Sciences, Soochow UniversityCenter of Super-Diamond and Advanced Films (COSDAF) & Department of Chemistry, City University of Hong KongCenter of Super-Diamond and Advanced Films (COSDAF) & Department of Chemistry, City University of Hong KongCollege of Pharmaceutical Sciences, Soochow UniversityInstitute of Functional Nano & Soft Materials (FUNSOM), Soochow UniversityHighlights By employing side-chain regulation, the photothermal therapy response of conjugated diradical polymer can red-shift from near-infrared (NIR)-I to the NIR-II region. This strategy offers new radical materials in developing NIR-II photothermal materials. The conjugated diradical polymer TTB-2 receives a record-high photothermal conversion efficiency of 87.7%, far beyond the recently reported NIR-II photothermal agents. Such conjugated diradical polymer must enrich the NIR-II photothermal agents’ library and provide important insight for more diradical polymer construction. The conjugated diradical polymer nanoparticles TTB-2 NPs achieve good tumor photoablation with navigation of photoacoustic imaging in the NIR-II window, without any side effect. Furthermore, the efficient photo-immunity effect prevents the pulmonary metastasis of breast cancer.https://doi.org/10.1007/s40820-023-01219-xNIR-II conjugated polymerPhotothermalRadicalNanoparticlesCancer therapy |
| spellingShingle | Yijian Gao Ying Liu Xiliang Li Hui Wang Yuliang Yang Yu Luo Yingpeng Wan Chun-sing Lee Shengliang Li Xiao-Hong Zhang A Stable Open-Shell Conjugated Diradical Polymer with Ultra-High Photothermal Conversion Efficiency for NIR-II Photo-Immunotherapy of Metastatic Tumor Nano-Micro Letters NIR-II conjugated polymer Photothermal Radical Nanoparticles Cancer therapy |
| title | A Stable Open-Shell Conjugated Diradical Polymer with Ultra-High Photothermal Conversion Efficiency for NIR-II Photo-Immunotherapy of Metastatic Tumor |
| title_full | A Stable Open-Shell Conjugated Diradical Polymer with Ultra-High Photothermal Conversion Efficiency for NIR-II Photo-Immunotherapy of Metastatic Tumor |
| title_fullStr | A Stable Open-Shell Conjugated Diradical Polymer with Ultra-High Photothermal Conversion Efficiency for NIR-II Photo-Immunotherapy of Metastatic Tumor |
| title_full_unstemmed | A Stable Open-Shell Conjugated Diradical Polymer with Ultra-High Photothermal Conversion Efficiency for NIR-II Photo-Immunotherapy of Metastatic Tumor |
| title_short | A Stable Open-Shell Conjugated Diradical Polymer with Ultra-High Photothermal Conversion Efficiency for NIR-II Photo-Immunotherapy of Metastatic Tumor |
| title_sort | stable open shell conjugated diradical polymer with ultra high photothermal conversion efficiency for nir ii photo immunotherapy of metastatic tumor |
| topic | NIR-II conjugated polymer Photothermal Radical Nanoparticles Cancer therapy |
| url | https://doi.org/10.1007/s40820-023-01219-x |
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