Biocatalytic route scouting and enzyme screening toward the synthesis of α-benzyl L-glutamate

We here report four biocatalytic approaches for the synthesis of the protected amino acid building block α-benzyl L-glutamate. Screenings of these routes to identify active and selective enzymes were conducted, and major hits were confirmed in retest reactions. In the first approach, N-Boc L-glutami...

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Bibliographic Details
Main Authors: Peter J. L. M. Quaedflieg, Lisanne M. H. Jente, Monika Müller, Linda Vermote, Victor Plesciuc, Jan-Metske van der Laan, Lone Nielsen, Martin Schürmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Catalysis
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fctls.2023.1285074/full