Experimental substantiation of osteotransplant ap- plication in traumatic vertebral defects
Objective. To analyze the features of bone tissue formation during plasty of vertebral body defect or fracture with an allogeneic bone graft in an experiment in vitro. Material and Methods. Models of the vertebral body defect (fracture of the cranioventral part with penetration into the nucleus...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Ministry of Health of Russian Federation, Federal State Budgetary Institution "Novosibirsk Research Institute of Traumatology and Orthopaedics n.a. Ya.L. Tsivyan"
2018-12-01
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| Series: | Хирургия позвоночника |
| Subjects: | |
| Online Access: | https://www.spinesurgery.ru/jour/article/view/1515/1490 |
| Summary: | Objective. To analyze the features of bone tissue formation during plasty of vertebral body defect or fracture with an allogeneic bone graft
in an experiment in vitro.
Material and Methods. Models of the vertebral body defect (fracture of the cranioventral part with penetration into the nucleus pulpo-
sus) were created in an experiment on 20 mini-pigs of the same age. Plasty of traumatic defects was performed with allogeneic bone graft
or autologous bone. CT, histological, and spectrometric studies of microscopic specimens were carried out at 14, 30, 90, and 180 day. Re-
parative osteogenesis, X-ray density, Ca and P content, and microhardness were studied.
Results. After implantation of allogeneic bone graft, an organ-specific bone similar to the recipient’s bone in morphological structure, X-ray
density, mineral composition and microhardness, was formed on the 90th day (P = 0.01). After transplantation of autobone, the regener-
ate formed by this day in the central part was in a phase of resorption and restructuring with lower indices of X-ray density, content of Ca
and P, and microhardness (P = 0.01).
Conclusion. Аfter plasty of vertebral body traumatic defects with allogeneic bone graft, the organ-specific bone tissue is formed at an ear-
lier time and reliably exhibits greater mineralization and strength. |
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| ISSN: | 1810-8997 2313-1497 |