Sensing the oxygen and temperature in the adipose tissues – who’s sensing what?
Abstract Adipose tissues, composed of various cell types, including adipocytes, endothelial cells, neurons, and immune cells, are organs that are exposed to dynamic environmental challenges. During diet-induced obesity, white adipose tissues experience hypoxia due to adipocyte hypertrophy and dysfun...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2023-11-01
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| Series: | Experimental and Molecular Medicine |
| Online Access: | https://doi.org/10.1038/s12276-023-01113-x |
| _version_ | 1797415907068215296 |
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| author | Gi-Sue Kang Hye-Ju Jo Ye-Rim Lee Taerim Oh Hye-Joon Park G-One Ahn |
| author_facet | Gi-Sue Kang Hye-Ju Jo Ye-Rim Lee Taerim Oh Hye-Joon Park G-One Ahn |
| author_sort | Gi-Sue Kang |
| collection | DOAJ |
| description | Abstract Adipose tissues, composed of various cell types, including adipocytes, endothelial cells, neurons, and immune cells, are organs that are exposed to dynamic environmental challenges. During diet-induced obesity, white adipose tissues experience hypoxia due to adipocyte hypertrophy and dysfunctional vasculature. Under these conditions, cells in white adipose tissues activate hypoxia-inducible factor (HIF), a transcription factor that activates signaling pathways involved in metabolism, angiogenesis, and survival/apoptosis to adapt to such an environment. Exposure to cold or activation of the β-adrenergic receptor (through catecholamines or chemicals) leads to heat generation, mainly in brown adipose tissues through activating uncoupling protein 1 (UCP1), a proton uncoupler in the inner membrane of the mitochondria. White adipose tissues can undergo a similar process under this condition, a phenomenon known as ‘browning’ of white adipose tissues or ‘beige adipocytes’. While UCP1 expression has largely been confined to adipocytes, HIF can be expressed in many types of cells. To dissect the role of HIF in specific types of cells during diet-induced obesity, researchers have generated tissue-specific knockout (KO) mice targeting HIF pathways, and many studies have commonly revealed that intact HIF-1 signaling in adipocytes and adipose tissue macrophages exacerbates tissue inflammation and insulin resistance. In this review, we highlight some of the key findings obtained from these transgenic mice, including Ucp1 KO mice and other models targeting the HIF pathway in adipocytes, macrophages, or endothelial cells, to decipher their roles in diet-induced obesity. |
| first_indexed | 2024-03-09T05:56:13Z |
| format | Article |
| id | doaj.art-605f485328ec4cb48704816fccc782f0 |
| institution | Directory Open Access Journal |
| issn | 2092-6413 |
| language | English |
| last_indexed | 2024-03-09T05:56:13Z |
| publishDate | 2023-11-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Experimental and Molecular Medicine |
| spelling | doaj.art-605f485328ec4cb48704816fccc782f02023-12-03T12:13:19ZengNature Publishing GroupExperimental and Molecular Medicine2092-64132023-11-0155112300230710.1038/s12276-023-01113-xSensing the oxygen and temperature in the adipose tissues – who’s sensing what?Gi-Sue Kang0Hye-Ju Jo1Ye-Rim Lee2Taerim Oh3Hye-Joon Park4G-One Ahn5College of Veterinary Medicine, Seoul National UniversityCollege of Veterinary Medicine, Seoul National UniversityCollege of Veterinary Medicine, Seoul National UniversityCollege of Veterinary Medicine, Seoul National UniversityCollege of Medicine, Seoul National UniversityCollege of Veterinary Medicine, Seoul National UniversityAbstract Adipose tissues, composed of various cell types, including adipocytes, endothelial cells, neurons, and immune cells, are organs that are exposed to dynamic environmental challenges. During diet-induced obesity, white adipose tissues experience hypoxia due to adipocyte hypertrophy and dysfunctional vasculature. Under these conditions, cells in white adipose tissues activate hypoxia-inducible factor (HIF), a transcription factor that activates signaling pathways involved in metabolism, angiogenesis, and survival/apoptosis to adapt to such an environment. Exposure to cold or activation of the β-adrenergic receptor (through catecholamines or chemicals) leads to heat generation, mainly in brown adipose tissues through activating uncoupling protein 1 (UCP1), a proton uncoupler in the inner membrane of the mitochondria. White adipose tissues can undergo a similar process under this condition, a phenomenon known as ‘browning’ of white adipose tissues or ‘beige adipocytes’. While UCP1 expression has largely been confined to adipocytes, HIF can be expressed in many types of cells. To dissect the role of HIF in specific types of cells during diet-induced obesity, researchers have generated tissue-specific knockout (KO) mice targeting HIF pathways, and many studies have commonly revealed that intact HIF-1 signaling in adipocytes and adipose tissue macrophages exacerbates tissue inflammation and insulin resistance. In this review, we highlight some of the key findings obtained from these transgenic mice, including Ucp1 KO mice and other models targeting the HIF pathway in adipocytes, macrophages, or endothelial cells, to decipher their roles in diet-induced obesity.https://doi.org/10.1038/s12276-023-01113-x |
| spellingShingle | Gi-Sue Kang Hye-Ju Jo Ye-Rim Lee Taerim Oh Hye-Joon Park G-One Ahn Sensing the oxygen and temperature in the adipose tissues – who’s sensing what? Experimental and Molecular Medicine |
| title | Sensing the oxygen and temperature in the adipose tissues – who’s sensing what? |
| title_full | Sensing the oxygen and temperature in the adipose tissues – who’s sensing what? |
| title_fullStr | Sensing the oxygen and temperature in the adipose tissues – who’s sensing what? |
| title_full_unstemmed | Sensing the oxygen and temperature in the adipose tissues – who’s sensing what? |
| title_short | Sensing the oxygen and temperature in the adipose tissues – who’s sensing what? |
| title_sort | sensing the oxygen and temperature in the adipose tissues who s sensing what |
| url | https://doi.org/10.1038/s12276-023-01113-x |
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