Macrophage-Derived Extracellular Vesicles as Carriers of Alarmins and Their Potential Involvement in Bone Homeostasis
Extracellular vesicles are a heterogeneous group of cell-derived membranous structures, which facilitate intercellular communication. Recent studies have highlighted the importance of extracellular vesicles in bone homeostasis, as mediators of crosstalk between different bone-resident cells. Osteobl...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-08-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.01901/full |
| _version_ | 1818162521258852352 |
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| author | Bartijn C. H. Pieters Alfredo Cappariello Martijn H. J. van den Bosch Peter L. E. M. van Lent Anna Teti Fons A. J. van de Loo |
| author_facet | Bartijn C. H. Pieters Alfredo Cappariello Martijn H. J. van den Bosch Peter L. E. M. van Lent Anna Teti Fons A. J. van de Loo |
| author_sort | Bartijn C. H. Pieters |
| collection | DOAJ |
| description | Extracellular vesicles are a heterogeneous group of cell-derived membranous structures, which facilitate intercellular communication. Recent studies have highlighted the importance of extracellular vesicles in bone homeostasis, as mediators of crosstalk between different bone-resident cells. Osteoblasts and osteoclasts are capable of releasing various types of extracellular vesicles that promote both osteogenesis, as well as, osteoclastogenesis, maintaining bone homeostasis. However, the contribution of immune cell-derived extracellular vesicles in bone homeostasis remains largely unknown. Recent proteomic studies showed that alarmins are abundantly present in/on macrophage-derived EVs. In this review we will describe these alarmins in the context of bone matrix regulation and discuss the potential contribution macrophage-derived EVs may have in this process. |
| first_indexed | 2024-12-11T16:34:59Z |
| format | Article |
| id | doaj.art-605f9676c5824d79a8960daa56856dc9 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T16:34:59Z |
| publishDate | 2019-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-605f9676c5824d79a8960daa56856dc92022-12-22T00:58:29ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-08-011010.3389/fimmu.2019.01901456518Macrophage-Derived Extracellular Vesicles as Carriers of Alarmins and Their Potential Involvement in Bone HomeostasisBartijn C. H. Pieters0Alfredo Cappariello1Martijn H. J. van den Bosch2Peter L. E. M. van Lent3Anna Teti4Fons A. J. van de Loo5Experimental Rheumatology, Radboud University Medical Center, Nijmegen, NetherlandsResearch Laboratories - Department of Oncohematology IRCCS Bambino Gesù Children's Hospital, Rome, ItalyExperimental Rheumatology, Radboud University Medical Center, Nijmegen, NetherlandsExperimental Rheumatology, Radboud University Medical Center, Nijmegen, NetherlandsDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, ItalyExperimental Rheumatology, Radboud University Medical Center, Nijmegen, NetherlandsExtracellular vesicles are a heterogeneous group of cell-derived membranous structures, which facilitate intercellular communication. Recent studies have highlighted the importance of extracellular vesicles in bone homeostasis, as mediators of crosstalk between different bone-resident cells. Osteoblasts and osteoclasts are capable of releasing various types of extracellular vesicles that promote both osteogenesis, as well as, osteoclastogenesis, maintaining bone homeostasis. However, the contribution of immune cell-derived extracellular vesicles in bone homeostasis remains largely unknown. Recent proteomic studies showed that alarmins are abundantly present in/on macrophage-derived EVs. In this review we will describe these alarmins in the context of bone matrix regulation and discuss the potential contribution macrophage-derived EVs may have in this process.https://www.frontiersin.org/article/10.3389/fimmu.2019.01901/fullalarminsbone homeostasisextracellular vesiclesexosomesmacrophages |
| spellingShingle | Bartijn C. H. Pieters Alfredo Cappariello Martijn H. J. van den Bosch Peter L. E. M. van Lent Anna Teti Fons A. J. van de Loo Macrophage-Derived Extracellular Vesicles as Carriers of Alarmins and Their Potential Involvement in Bone Homeostasis Frontiers in Immunology alarmins bone homeostasis extracellular vesicles exosomes macrophages |
| title | Macrophage-Derived Extracellular Vesicles as Carriers of Alarmins and Their Potential Involvement in Bone Homeostasis |
| title_full | Macrophage-Derived Extracellular Vesicles as Carriers of Alarmins and Their Potential Involvement in Bone Homeostasis |
| title_fullStr | Macrophage-Derived Extracellular Vesicles as Carriers of Alarmins and Their Potential Involvement in Bone Homeostasis |
| title_full_unstemmed | Macrophage-Derived Extracellular Vesicles as Carriers of Alarmins and Their Potential Involvement in Bone Homeostasis |
| title_short | Macrophage-Derived Extracellular Vesicles as Carriers of Alarmins and Their Potential Involvement in Bone Homeostasis |
| title_sort | macrophage derived extracellular vesicles as carriers of alarmins and their potential involvement in bone homeostasis |
| topic | alarmins bone homeostasis extracellular vesicles exosomes macrophages |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2019.01901/full |
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