Radiation therapy attenuates lymphatic vessel repair by reducing VEGFR-3 signalling

Radiation therapy attenuates lymphatic vessel repair by reducing VEGFR-3 signalling

Introduction: Surgery and radiotherapy are key cancer treatments and the leading causes of damage to the lymphatics, a vascular network critical to fluid homeostasis and immunity. The clinical manifestation of this damage constitutes a devastating side-effect of cancer treatment, known as lymphoedem...

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Bibliographic Details
Main Authors: Vinochani Pillay, Lipi Shukla, Prad Herle, Simon Maciburko, Nadeeka Bandara, Isabella Reid, Steven Morgan, Yinan Yuan, Jennii Luu, Karla J. Cowley, Susanne Ramm, Kaylene J. Simpson, Marc G. Achen, Steven A. Stacker, Ramin Shayan, Tara Karnezis
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Pharmacology
Subjects:
radiotherapy
VEGFR-3
VEGF-C
lymphoedema
radiation-injury
LEC
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1152314/full

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