MSCs-engineered biomimetic PMAA nanomedicines for multiple bioimaging-guided and photothermal-enhanced radiotherapy of NSCLC
Abstract Background The recently developed biomimetic strategy is one of the mostly effective strategies for improving the theranostic efficacy of diverse nanomedicines, because nanoparticles coated with cell membranes can disguise as “self”, evade the surveillance of the immune system, and accumula...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-03-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-021-00823-6 |
| _version_ | 1811279475197870080 |
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| author | Yipengchen Yin Yongjing Li Sheng Wang Ziliang Dong Chao Liang Jiaxin Sun Changchun Wang Rong Chai Weiwei Fei Jianping Zhang Ming Qi Liangzhu Feng Qin Zhang |
| author_facet | Yipengchen Yin Yongjing Li Sheng Wang Ziliang Dong Chao Liang Jiaxin Sun Changchun Wang Rong Chai Weiwei Fei Jianping Zhang Ming Qi Liangzhu Feng Qin Zhang |
| author_sort | Yipengchen Yin |
| collection | DOAJ |
| description | Abstract Background The recently developed biomimetic strategy is one of the mostly effective strategies for improving the theranostic efficacy of diverse nanomedicines, because nanoparticles coated with cell membranes can disguise as “self”, evade the surveillance of the immune system, and accumulate to the tumor sites actively. Results Herein, we utilized mesenchymal stem cell memabranes (MSCs) to coat polymethacrylic acid (PMAA) nanoparticles loaded with Fe(III) and cypate—an derivative of indocyanine green to fabricate Cyp-PMAA-Fe@MSCs, which featured high stability, desirable tumor-accumulation and intriguing photothermal conversion efficiency both in vitro and in vivo for the treatment of lung cancer. After intravenous administration of Cyp-PMAA-Fe@MSCs and Cyp-PMAA-Fe@RBCs (RBCs, red blood cell membranes) separately into tumor-bearing mice, the fluorescence signal in the MSCs group was 21% stronger than that in the RBCs group at the tumor sites in an in vivo fluorescence imaging system. Correspondingly, the T 1-weighted magnetic resonance imaging (MRI) signal at the tumor site decreased 30% after intravenous injection of Cyp-PMAA-Fe@MSCs. Importantly, the constructed Cyp-PMAA-Fe@MSCs exhibited strong photothermal hyperthermia effect both in vitro and in vivo when exposed to 808 nm laser irradiation, thus it could be used for photothermal therapy. Furthermore, tumors on mice treated with phototermal therapy and radiotherapy shrank 32% more than those treated with only radiotherapy. Conclusions These results proved that Cyp-PMAA-Fe@MSCs could realize fluorescence/MRI bimodal imaging, while be used in phototermal-therapy-enhanced radiotherapy, providing desirable nanoplatforms for tumor diagnosis and precise treatment of non-small cell lung cancer. |
| first_indexed | 2024-04-13T00:55:12Z |
| format | Article |
| id | doaj.art-6062115367604e24b179c48d4a360a38 |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-13T00:55:12Z |
| publishDate | 2021-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-6062115367604e24b179c48d4a360a382022-12-22T03:09:41ZengBMCJournal of Nanobiotechnology1477-31552021-03-0119111310.1186/s12951-021-00823-6MSCs-engineered biomimetic PMAA nanomedicines for multiple bioimaging-guided and photothermal-enhanced radiotherapy of NSCLCYipengchen Yin0Yongjing Li1Sheng Wang2Ziliang Dong3Chao Liang4Jiaxin Sun5Changchun Wang6Rong Chai7Weiwei Fei8Jianping Zhang9Ming Qi10Liangzhu Feng11Qin Zhang12Department of Radiation Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong UniversityState Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, and Laboratory of Advanced Materials, Fudan UniversityDepartment of Colorectal Surgery, Fudan University Shanghai Cancer CenterJiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials (FUNSOM), Soochow UniversityJiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials (FUNSOM), Soochow UniversityState Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, and Laboratory of Advanced Materials, Fudan UniversityState Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, and Laboratory of Advanced Materials, Fudan UniversityDepartment of Radiation Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong UniversityState Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, and Laboratory of Advanced Materials, Fudan UniversityDepartment of Nuclear Medicine, Fudan University Shanghai Cancer CenterDepartment of Nuclear Medicine, Fudan University Shanghai Cancer CenterJiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials (FUNSOM), Soochow UniversityDepartment of Radiation Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong UniversityAbstract Background The recently developed biomimetic strategy is one of the mostly effective strategies for improving the theranostic efficacy of diverse nanomedicines, because nanoparticles coated with cell membranes can disguise as “self”, evade the surveillance of the immune system, and accumulate to the tumor sites actively. Results Herein, we utilized mesenchymal stem cell memabranes (MSCs) to coat polymethacrylic acid (PMAA) nanoparticles loaded with Fe(III) and cypate—an derivative of indocyanine green to fabricate Cyp-PMAA-Fe@MSCs, which featured high stability, desirable tumor-accumulation and intriguing photothermal conversion efficiency both in vitro and in vivo for the treatment of lung cancer. After intravenous administration of Cyp-PMAA-Fe@MSCs and Cyp-PMAA-Fe@RBCs (RBCs, red blood cell membranes) separately into tumor-bearing mice, the fluorescence signal in the MSCs group was 21% stronger than that in the RBCs group at the tumor sites in an in vivo fluorescence imaging system. Correspondingly, the T 1-weighted magnetic resonance imaging (MRI) signal at the tumor site decreased 30% after intravenous injection of Cyp-PMAA-Fe@MSCs. Importantly, the constructed Cyp-PMAA-Fe@MSCs exhibited strong photothermal hyperthermia effect both in vitro and in vivo when exposed to 808 nm laser irradiation, thus it could be used for photothermal therapy. Furthermore, tumors on mice treated with phototermal therapy and radiotherapy shrank 32% more than those treated with only radiotherapy. Conclusions These results proved that Cyp-PMAA-Fe@MSCs could realize fluorescence/MRI bimodal imaging, while be used in phototermal-therapy-enhanced radiotherapy, providing desirable nanoplatforms for tumor diagnosis and precise treatment of non-small cell lung cancer.https://doi.org/10.1186/s12951-021-00823-6Cancer theranosticsBiomimetic nanoparticlesActive targetingBimodal imagingPhotothermal therapyRadiotherapy |
| spellingShingle | Yipengchen Yin Yongjing Li Sheng Wang Ziliang Dong Chao Liang Jiaxin Sun Changchun Wang Rong Chai Weiwei Fei Jianping Zhang Ming Qi Liangzhu Feng Qin Zhang MSCs-engineered biomimetic PMAA nanomedicines for multiple bioimaging-guided and photothermal-enhanced radiotherapy of NSCLC Journal of Nanobiotechnology Cancer theranostics Biomimetic nanoparticles Active targeting Bimodal imaging Photothermal therapy Radiotherapy |
| title | MSCs-engineered biomimetic PMAA nanomedicines for multiple bioimaging-guided and photothermal-enhanced radiotherapy of NSCLC |
| title_full | MSCs-engineered biomimetic PMAA nanomedicines for multiple bioimaging-guided and photothermal-enhanced radiotherapy of NSCLC |
| title_fullStr | MSCs-engineered biomimetic PMAA nanomedicines for multiple bioimaging-guided and photothermal-enhanced radiotherapy of NSCLC |
| title_full_unstemmed | MSCs-engineered biomimetic PMAA nanomedicines for multiple bioimaging-guided and photothermal-enhanced radiotherapy of NSCLC |
| title_short | MSCs-engineered biomimetic PMAA nanomedicines for multiple bioimaging-guided and photothermal-enhanced radiotherapy of NSCLC |
| title_sort | mscs engineered biomimetic pmaa nanomedicines for multiple bioimaging guided and photothermal enhanced radiotherapy of nsclc |
| topic | Cancer theranostics Biomimetic nanoparticles Active targeting Bimodal imaging Photothermal therapy Radiotherapy |
| url | https://doi.org/10.1186/s12951-021-00823-6 |
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