Association between Immunosuppressive Therapy Utilized in the Treatment of Autoimmune Disease or Transplant and Cancer Progression
Autoimmunity and cancer rates have both been on the rise in Western civilization prompting many to investigate the link between the two entities. This review will investigate the complex interactions between the activation and deactivation of the immune system and the development of malignancy. Addi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-12-01
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| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/11/1/99 |
| _version_ | 1797445669191942144 |
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| author | Amanda Reyes Atish Mohanty Rebecca Pharaon Erminia Massarelli |
| author_facet | Amanda Reyes Atish Mohanty Rebecca Pharaon Erminia Massarelli |
| author_sort | Amanda Reyes |
| collection | DOAJ |
| description | Autoimmunity and cancer rates have both been on the rise in Western civilization prompting many to investigate the link between the two entities. This review will investigate the complex interactions between the activation and deactivation of the immune system and the development of malignancy. Additional focus will be placed on the main classes of immune inhibitor therapy utilized in transplant patients and in autoimmune disease including TNF-alpha, Calcineurin, mTOR, purine synthesis antagonists and IMPDH inhibitors. |
| first_indexed | 2024-03-09T13:30:08Z |
| format | Article |
| id | doaj.art-606251773bca4b29855093980539ebe4 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T13:30:08Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-606251773bca4b29855093980539ebe42023-11-30T21:19:25ZengMDPI AGBiomedicines2227-90592022-12-011119910.3390/biomedicines11010099Association between Immunosuppressive Therapy Utilized in the Treatment of Autoimmune Disease or Transplant and Cancer ProgressionAmanda Reyes0Atish Mohanty1Rebecca Pharaon2Erminia Massarelli3Department of Medical Oncology & Therapeutics Research, City of Hope National Medical Center, Duarte, CA 91010, USADepartment of Medical Oncology & Therapeutics Research, City of Hope National Medical Center, Duarte, CA 91010, USADepartment of Medical Oncology & Therapeutics Research, City of Hope National Medical Center, Duarte, CA 91010, USADepartment of Medical Oncology & Therapeutics Research, City of Hope National Medical Center, Duarte, CA 91010, USAAutoimmunity and cancer rates have both been on the rise in Western civilization prompting many to investigate the link between the two entities. This review will investigate the complex interactions between the activation and deactivation of the immune system and the development of malignancy. Additional focus will be placed on the main classes of immune inhibitor therapy utilized in transplant patients and in autoimmune disease including TNF-alpha, Calcineurin, mTOR, purine synthesis antagonists and IMPDH inhibitors.https://www.mdpi.com/2227-9059/11/1/99autoimmunityimmunodeficiencyimmunosurveillanceTNF-alpha inhibitorscalcineurin inhibitorsmTOR inhibitors |
| spellingShingle | Amanda Reyes Atish Mohanty Rebecca Pharaon Erminia Massarelli Association between Immunosuppressive Therapy Utilized in the Treatment of Autoimmune Disease or Transplant and Cancer Progression Biomedicines autoimmunity immunodeficiency immunosurveillance TNF-alpha inhibitors calcineurin inhibitors mTOR inhibitors |
| title | Association between Immunosuppressive Therapy Utilized in the Treatment of Autoimmune Disease or Transplant and Cancer Progression |
| title_full | Association between Immunosuppressive Therapy Utilized in the Treatment of Autoimmune Disease or Transplant and Cancer Progression |
| title_fullStr | Association between Immunosuppressive Therapy Utilized in the Treatment of Autoimmune Disease or Transplant and Cancer Progression |
| title_full_unstemmed | Association between Immunosuppressive Therapy Utilized in the Treatment of Autoimmune Disease or Transplant and Cancer Progression |
| title_short | Association between Immunosuppressive Therapy Utilized in the Treatment of Autoimmune Disease or Transplant and Cancer Progression |
| title_sort | association between immunosuppressive therapy utilized in the treatment of autoimmune disease or transplant and cancer progression |
| topic | autoimmunity immunodeficiency immunosurveillance TNF-alpha inhibitors calcineurin inhibitors mTOR inhibitors |
| url | https://www.mdpi.com/2227-9059/11/1/99 |
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