POTENTIAL MOLECULES AGAINST COVID-19 FROM ANNONA MURICATA; AN IN-SILICO APPROACH
At the end of 2019, a new virus emerged from Wuhan, China named Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The key to viral infection to host cells is the use of the ACE2 receptor. This study aimed to explore the potential of drugs in Annona muricata plant using the Insilico meth...
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| Format: | Article |
| Language: | Indonesian |
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Fakultas Kesehatan Universitas Nahdlatul Ulama Surabaya
2022-08-01
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| Series: | Medical Technology and Public Health Journal |
| Subjects: | |
| Online Access: | https://103.106.72.77/index.php/MTPHJ/article/view/3069 |
| _version_ | 1817995039420186624 |
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| author | Miftahul Mushlih Mushlih Andika Aliviameita Puspitasari Puspitasari Ahmad Shobrun Jamil |
| author_facet | Miftahul Mushlih Mushlih Andika Aliviameita Puspitasari Puspitasari Ahmad Shobrun Jamil |
| author_sort | Miftahul Mushlih Mushlih |
| collection | DOAJ |
| description |
At the end of 2019, a new virus emerged from Wuhan, China named Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The key to viral infection to host cells is the use of the ACE2 receptor. This study aimed to explore the potential of drugs in Annona muricata plant using the Insilico method. Compounds obtained from KNApSAcK Based on the analysis using SwissADME (Lipinski creteria)criteria. 22 compounds passed the selection. Eight ligands were identified as being able to change the conformation of the initial form of RBD and ACE2 attachment. Eight molecules are able to change the initial conformation, namely Asimilobine, Coreximine, (+)-Stepharine, Coclaurine, Norcorydine, N- Nornuciferinhe, methoxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinolin-5-ol, and Atherosperminine.
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| first_indexed | 2024-04-14T02:01:28Z |
| format | Article |
| id | doaj.art-6063a5be5d5146ddb2bd3b8773cd0d41 |
| institution | Directory Open Access Journal |
| issn | 2549-189X 2549-2993 |
| language | Indonesian |
| last_indexed | 2024-04-14T02:01:28Z |
| publishDate | 2022-08-01 |
| publisher | Fakultas Kesehatan Universitas Nahdlatul Ulama Surabaya |
| record_format | Article |
| series | Medical Technology and Public Health Journal |
| spelling | doaj.art-6063a5be5d5146ddb2bd3b8773cd0d412022-12-22T02:18:50ZindFakultas Kesehatan Universitas Nahdlatul Ulama SurabayaMedical Technology and Public Health Journal2549-189X2549-29932022-08-016110.33086/mtphj.v6i1.3069POTENTIAL MOLECULES AGAINST COVID-19 FROM ANNONA MURICATA; AN IN-SILICO APPROACHMiftahul Mushlih Mushlih0Andika AliviameitaPuspitasari PuspitasariAhmad Shobrun Jamiluniversitas Muhammadiyah Sidoarjo At the end of 2019, a new virus emerged from Wuhan, China named Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The key to viral infection to host cells is the use of the ACE2 receptor. This study aimed to explore the potential of drugs in Annona muricata plant using the Insilico method. Compounds obtained from KNApSAcK Based on the analysis using SwissADME (Lipinski creteria)criteria. 22 compounds passed the selection. Eight ligands were identified as being able to change the conformation of the initial form of RBD and ACE2 attachment. Eight molecules are able to change the initial conformation, namely Asimilobine, Coreximine, (+)-Stepharine, Coclaurine, Norcorydine, N- Nornuciferinhe, methoxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinolin-5-ol, and Atherosperminine. https://103.106.72.77/index.php/MTPHJ/article/view/3069booster covid-19SARS-CoV-2herbalmedicine |
| spellingShingle | Miftahul Mushlih Mushlih Andika Aliviameita Puspitasari Puspitasari Ahmad Shobrun Jamil POTENTIAL MOLECULES AGAINST COVID-19 FROM ANNONA MURICATA; AN IN-SILICO APPROACH Medical Technology and Public Health Journal booster covid-19 SARS-CoV-2 herbal medicine |
| title | POTENTIAL MOLECULES AGAINST COVID-19 FROM ANNONA MURICATA; AN IN-SILICO APPROACH |
| title_full | POTENTIAL MOLECULES AGAINST COVID-19 FROM ANNONA MURICATA; AN IN-SILICO APPROACH |
| title_fullStr | POTENTIAL MOLECULES AGAINST COVID-19 FROM ANNONA MURICATA; AN IN-SILICO APPROACH |
| title_full_unstemmed | POTENTIAL MOLECULES AGAINST COVID-19 FROM ANNONA MURICATA; AN IN-SILICO APPROACH |
| title_short | POTENTIAL MOLECULES AGAINST COVID-19 FROM ANNONA MURICATA; AN IN-SILICO APPROACH |
| title_sort | potential molecules against covid 19 from annona muricata an in silico approach |
| topic | booster covid-19 SARS-CoV-2 herbal medicine |
| url | https://103.106.72.77/index.php/MTPHJ/article/view/3069 |
| work_keys_str_mv | AT miftahulmushlihmushlih potentialmoleculesagainstcovid19fromannonamuricataaninsilicoapproach AT andikaaliviameita potentialmoleculesagainstcovid19fromannonamuricataaninsilicoapproach AT puspitasaripuspitasari potentialmoleculesagainstcovid19fromannonamuricataaninsilicoapproach AT ahmadshobrunjamil potentialmoleculesagainstcovid19fromannonamuricataaninsilicoapproach |