The Potential Application and Promising Role of Targeted Therapy in Pulmonary Arterial Hypertension

The Potential Application and Promising Role of Targeted Therapy in Pulmonary Arterial Hypertension

Pulmonary arterial hypertension (PAH) is a rare yet serious progressive disorder that is currently incurable. This female-predominant disease unfolds as a pan-vasculopathy that affects all layers of the vessel wall. Five classes of pharmacological agents currently exist to target the three major cel...

Full description

Bibliographic Details
Main Authors:	Meng-Chien Willie Hsieh, Wei-Ting Wang, Jwu-Lai Yeh, Chuang-Yu Lin, Yur-Ren Kuo, Su-Shin Lee, Ming-Feng Hou, Yi-Chia Wu
Format:	Article
Language:	English
Published:	MDPI AG 2022-06-01
Series:	Biomedicines
Subjects:	pulmonary arterial hypertension molecular base pathophysiology targeted therapy Warburg Effect
Online Access:	https://www.mdpi.com/2227-9059/10/6/1415

Similar Items

Perioperative Management of Pulmonary Hypertension. A Review
by: Wood Christopher, et al.
Published: (2021-05-01)

Mitochondrial Dysfunction in Pulmonary Hypertension
by: Gusty Rizky Teguh Ryanto, et al.
Published: (2023-02-01)

Muscle strength is reduced in children with pulmonary arterial hypertension
by: Shari Pepplinkhuizen, et al.
Published: (2023-04-01)

New progress in diagnosis and treatment of pulmonary arterial hypertension
by: Zai-qiang Zhang, et al.
Published: (2022-08-01)

Pulmonary Hypertension in Left Heart Diseases: Pathophysiology, Hemodynamic Assessment and Therapeutic Management
by: Zied Ltaief, et al.
Published: (2023-06-01)

Therapeutic Challenges and Emerging Treatment Targets for Pulmonary Hypertension in Left Heart Disease
by: Christelle Lteif, et al.
Published: (2021-06-01)

Pathophysiology, Management and Outcome of Persistent Pulmonary Hypertension of the Newborn: a Clinical Review
by: Maroun Jean Mhanna, et al.
Published: (2013-09-01)

Perspectives of using pulmonary arterial stiffness indicators to evaluate the prognosis of patients with pulmonary arterial hypertension
by: M.A. SIMAKOVA, et al.
Published: (2018-01-01)

Perspectives of using pulmonary arterial stiffness indicators to evaluate the prognosis of patients with pulmonary arterial hypertension
by: M A Simakova, et al.
Published: (2018-01-01)

Antioxidant-Conjugated Peptide Attenuated Metabolic Reprogramming in Pulmonary Hypertension
by: Mathews Valuparampil Varghese, et al.
Published: (2020-01-01)

Targeting Mitochondrial Metabolic Dysfunction in Pulmonary Hypertension: Toward New Therapeutic Approaches?
by: Marianne Riou, et al.
Published: (2023-05-01)

The Impact of Heterozygous KCNK3 Mutations Associated With Pulmonary Arterial Hypertension on Channel Function and Pharmacological Recovery
by: Michael S. Bohnen, et al.
Published: (2017-09-01)

Pulmonary arterial hypertension: the case for a bioelectronic treatment
by: Despοina Ntiloudi, et al.
Published: (2019-12-01)

Immunity and inflammation in pulmonary arterial hypertension: From pathophysiology mechanisms to treatment perspective
by: Ran-ran Wang, et al.
Published: (2022-06-01)

Pulsatile pulmonary artery pressure in a large animal model of chronic thromboembolic pulmonary hypertension: Similarities and differences with human data
by: David Boulate, et al.
Published: (2022-01-01)

The novel roles of YULINK in the migration, proliferation and glycolysis of pulmonary arterial smooth muscle cells: implications for pulmonary arterial hypertension
by: Yi-Chia Wu, et al.
Published: (2023-12-01)

Pulmonary hypertension secondary to interstitial fibrosis with pulmonary venous lesions masquerading pulmonary veno‐occlusive disease
by: Hiroki Nakayama, et al.
Published: (2023-07-01)

Case report: Pathological differences in pulmonary arterial hypertension in long-term responders to calcium channel blockers
by: Yuichi Tamura, et al.
Published: (2023-11-01)

Insights into Endothelin Receptors in Pulmonary Hypertension
by: Ruiqi Liu, et al.
Published: (2023-06-01)

Pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension—A single-center experience in Taiwan
by: Wei-Cheng Luo, et al.
Published: (2015-12-01)

Pathogenesis, clinical features, and phenotypes of pulmonary hypertension associated with interstitial lung disease: A consensus statement from the Pulmonary Vascular Research Institute's Innovative Drug Development Initiative ‐ Group 3 Pulmonary Hypertension
by: Lucilla Piccari, et al.
Published: (2023-04-01)

Saudi Guidelines on the Diagnosis and Treatment of Pulmonary Hypertension: Medical and surgical management for pulmonary arterial hypertension
by: Majdy M. Idrees, et al.
Published: (2014-01-01)

Recent trends in pulmonary arterial hypertension
by: Rajagopalan Natarajan
Published: (2011-01-01)

THE PATHOPHYSIOLOGY RELATIONSHIP OF HYPERTENSION AND RENAL HYPERTENSION
by: Akmarawita Kadir
Published: (2018-02-01)

Evolution of pulmonary hypertension in interstitial lung disease: a journey through past, present, and future
by: Ahmad Arslan, et al.
Published: (2024-01-01)

A current review on animal models of anti-hypertensive drugs screening
by: Mehvish Bhat, et al.
Published: (2023-03-01)

Recent Advances in the Treatment of Pulmonary Arterial Hypertension
by: Naoyuki Otani, et al.
Published: (2022-10-01)

Novel hub genes associated with pulmonary artery remodeling in pulmonary hypertension
by: Rubin Tan, et al.
Published: (2022-11-01)

Saudi experience in the management of pulmonary arterial hypertension; the outcome of PAH therapy with the exclusion of chronic parenteral prostacyclin
by: Majdy Idrees, et al.
Published: (2015-01-01)

CTLA-4 Expression Is a Promising Biomarker of Idiopathic Pulmonary Arterial Hypertension and Allows Differentiation of the Type of Pulmonary Hypertension
by: Michał Tomaszewski, et al.
Published: (2022-12-01)

Sarcoidosis-associated pulmonary hypertension
by: Kašiković-Lečić Svetlana, et al.
Published: (2022-01-01)

Comparing Diagnosis and Treatment of Pulmonary Hypertension Patients at a Pulmonary Hypertension Center versus Community Centers
by: Hollie Saunders, et al.
Published: (2022-01-01)

Efficacy and safety of balloon pulmonary angioplasty in patients with inoperable chronic thromboembolic pulmonary hypertension
by: Zheng-Wei Chen, et al.
Published: (2021-03-01)

Prostaglandin and prostaglandin receptors: present and future promising therapeutic targets for pulmonary arterial hypertension
by: Cheng Zeng, et al.
Published: (2023-11-01)

Balloon Pulmonary Angioplasty in Patients with Chronic Thromboembolic Pulmonary Hypertension in Greece: Data from the Hellenic Pulmonary Hypertension Registry
by: Panagiotis Karyofyllis, et al.
Published: (2022-04-01)

Cardiovascular magnetic resonance in pulmonary hypertension
by: Bradlow William M, et al.
Published: (2012-01-01)

Experimental Schistosoma haematobium pulmonary hypertension
by: Biruk Kassa, et al.
Published: (2024-01-01)

Rehabilitation in patients with pulmonary arterial hypertension
by: Stephan Keusch, et al.
Published: (2017-07-01)

Pulmonary arterial hypertension: diagnosis and treatment
by: Marcin Sadowski, et al.
Published: (2013-10-01)

Pulmonary Hypertension in Pregnancy: Challenges and Solutions
by: Afify H, et al.
Published: (2022-04-01)