The Role of Low-Level Laser Therapy in Bone Healing: Systematic Review
Low-level laser therapy (LLLT) is a treatment that is increasingly used in orthopedics practices. In vivo and in vitro studies have shown that low-level laser therapy (LLLT) promotes angiogenesis, fracture healing and osteogenic differentiation of stem cells. However, the underlying mechanisms durin...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/8/7094 |
| _version_ | 1797605152992002048 |
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| author | Micaela Berni Alice Maria Brancato Camilla Torriani Valentina Bina Salvatore Annunziata Elena Cornella Michelangelo Trucchi Eugenio Jannelli Mario Mosconi Giulia Gastaldi Laura Caliogna Federico Alberto Grassi Gianluigi Pasta |
| author_facet | Micaela Berni Alice Maria Brancato Camilla Torriani Valentina Bina Salvatore Annunziata Elena Cornella Michelangelo Trucchi Eugenio Jannelli Mario Mosconi Giulia Gastaldi Laura Caliogna Federico Alberto Grassi Gianluigi Pasta |
| author_sort | Micaela Berni |
| collection | DOAJ |
| description | Low-level laser therapy (LLLT) is a treatment that is increasingly used in orthopedics practices. In vivo and in vitro studies have shown that low-level laser therapy (LLLT) promotes angiogenesis, fracture healing and osteogenic differentiation of stem cells. However, the underlying mechanisms during bone formation remain largely unknown. Factors such as wavelength, energy density, irradiation and frequency of LLLT can influence the cellular mechanisms. Moreover, the effects of LLLT are different according to cell types treated. This review aims to summarize the current knowledge of the molecular pathways activated by LLLT and its effects on the bone healing process. A better understanding of the cellular mechanisms activated by LLLT can improve its clinical application. |
| first_indexed | 2024-03-11T04:57:04Z |
| format | Article |
| id | doaj.art-6064edc9cc154638866cd30384f125cc |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T04:57:04Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-6064edc9cc154638866cd30384f125cc2023-11-17T19:35:08ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-04-01248709410.3390/ijms24087094The Role of Low-Level Laser Therapy in Bone Healing: Systematic ReviewMicaela Berni0Alice Maria Brancato1Camilla Torriani2Valentina Bina3Salvatore Annunziata4Elena Cornella5Michelangelo Trucchi6Eugenio Jannelli7Mario Mosconi8Giulia Gastaldi9Laura Caliogna10Federico Alberto Grassi11Gianluigi Pasta12Orthopedics and Traumatology Clinic, IRCCS Policlinico San Matteo Foundation, 27100 Pavia, ItalyOrthopedics and Traumatology Clinic, IRCCS Policlinico San Matteo Foundation, 27100 Pavia, ItalyOrthopedics and Traumatology Clinic, IRCCS Policlinico San Matteo Foundation, 27100 Pavia, ItalyDepartment of Molecular Medicine, University of Pavia, 27100 Pavia, ItalyOrthopedics and Traumatology Clinic, IRCCS Policlinico San Matteo Foundation, 27100 Pavia, ItalyOrthopedics and Traumatology Clinic, IRCCS Policlinico San Matteo Foundation, 27100 Pavia, ItalyOrthopedics and Traumatology Clinic, IRCCS Policlinico San Matteo Foundation, 27100 Pavia, ItalyOrthopedics and Traumatology Clinic, IRCCS Policlinico San Matteo Foundation, 27100 Pavia, ItalyOrthopedics and Traumatology Clinic, IRCCS Policlinico San Matteo Foundation, 27100 Pavia, ItalyDepartment of Molecular Medicine, University of Pavia, 27100 Pavia, ItalyOrthopedics and Traumatology Clinic, IRCCS Policlinico San Matteo Foundation, 27100 Pavia, ItalyOrthopedics and Traumatology Clinic, IRCCS Policlinico San Matteo Foundation, 27100 Pavia, ItalyOrthopedics and Traumatology Clinic, IRCCS Policlinico San Matteo Foundation, 27100 Pavia, ItalyLow-level laser therapy (LLLT) is a treatment that is increasingly used in orthopedics practices. In vivo and in vitro studies have shown that low-level laser therapy (LLLT) promotes angiogenesis, fracture healing and osteogenic differentiation of stem cells. However, the underlying mechanisms during bone formation remain largely unknown. Factors such as wavelength, energy density, irradiation and frequency of LLLT can influence the cellular mechanisms. Moreover, the effects of LLLT are different according to cell types treated. This review aims to summarize the current knowledge of the molecular pathways activated by LLLT and its effects on the bone healing process. A better understanding of the cellular mechanisms activated by LLLT can improve its clinical application.https://www.mdpi.com/1422-0067/24/8/7094low-level laser therapy (LLLT)phototherapyphoto-biomodulationbone regenerationbone healingbone fracture healing |
| spellingShingle | Micaela Berni Alice Maria Brancato Camilla Torriani Valentina Bina Salvatore Annunziata Elena Cornella Michelangelo Trucchi Eugenio Jannelli Mario Mosconi Giulia Gastaldi Laura Caliogna Federico Alberto Grassi Gianluigi Pasta The Role of Low-Level Laser Therapy in Bone Healing: Systematic Review International Journal of Molecular Sciences low-level laser therapy (LLLT) phototherapy photo-biomodulation bone regeneration bone healing bone fracture healing |
| title | The Role of Low-Level Laser Therapy in Bone Healing: Systematic Review |
| title_full | The Role of Low-Level Laser Therapy in Bone Healing: Systematic Review |
| title_fullStr | The Role of Low-Level Laser Therapy in Bone Healing: Systematic Review |
| title_full_unstemmed | The Role of Low-Level Laser Therapy in Bone Healing: Systematic Review |
| title_short | The Role of Low-Level Laser Therapy in Bone Healing: Systematic Review |
| title_sort | role of low level laser therapy in bone healing systematic review |
| topic | low-level laser therapy (LLLT) phototherapy photo-biomodulation bone regeneration bone healing bone fracture healing |
| url | https://www.mdpi.com/1422-0067/24/8/7094 |
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