Adrenomedullin Mitigates Doxorubicin-Induced Nephrotoxicity in Rats: Role of Oxidative Stress, Inflammation, Apoptosis, and Pyroptosis

Adrenomedullin Mitigates Doxorubicin-Induced Nephrotoxicity in Rats: Role of Oxidative Stress, Inflammation, Apoptosis, and Pyroptosis

Doxorubicin (DOX) is an anticancer antibiotic which has various effects in human cancers. It is one of the commonly known causes of drug-induced nephrotoxicity, which results in acute renal injury. Adrenomedullin (ADM), a vasodilator peptide, is widely distributed in many tissues and has potent prot...

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Bibliographic Details
Main Authors: Rania Nagi Abd-Ellatif, Nahla Anas Nasef, Hemat El-Sayed El-Horany, Marwa Nagy Emam, Reham Lotfy Younis, Rehab E. Abo El Gheit, Walaa Elseady, Doaa A. Radwan, Yasser Mostafa Hafez, Ahmad Eissa, Alshimaa Aboalsoud, Rania H. Shalaby, Marwa Mohamed Atef
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:International Journal of Molecular Sciences
Subjects:
nephrotoxicity
doxorubicin
adrenomedullin
pyroptosis
gasdermin
Online Access:https://www.mdpi.com/1422-0067/23/23/14570

Internet

https://www.mdpi.com/1422-0067/23/23/14570

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