An investigation of causal relationships between prediabetes and vascular complications
Prediabetes has been associated with diabetes complications, but these relationships may be confounded. Here the authors show, using genetic data in causal inference analyses, that prediabetes raises risk of coronary heart disease, but not other diabetes complications.
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-18386-9 |
| _version_ | 1818401568622379008 |
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| author | Pascal M. Mutie Hugo Pomares-Millan Naeimeh Atabaki-Pasdar Nina Jordan Rachel Adams Nicole L. Daly Juan Fernandes Tajes Giuseppe N. Giordano Paul W. Franks |
| author_facet | Pascal M. Mutie Hugo Pomares-Millan Naeimeh Atabaki-Pasdar Nina Jordan Rachel Adams Nicole L. Daly Juan Fernandes Tajes Giuseppe N. Giordano Paul W. Franks |
| author_sort | Pascal M. Mutie |
| collection | DOAJ |
| description | Prediabetes has been associated with diabetes complications, but these relationships may be confounded. Here the authors show, using genetic data in causal inference analyses, that prediabetes raises risk of coronary heart disease, but not other diabetes complications. |
| first_indexed | 2024-12-14T07:54:32Z |
| format | Article |
| id | doaj.art-606683e303cd49249b14a925acdda959 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T07:54:32Z |
| publishDate | 2020-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-606683e303cd49249b14a925acdda9592022-12-21T23:10:35ZengNature PortfolioNature Communications2041-17232020-09-0111111110.1038/s41467-020-18386-9An investigation of causal relationships between prediabetes and vascular complicationsPascal M. Mutie0Hugo Pomares-Millan1Naeimeh Atabaki-Pasdar2Nina Jordan3Rachel Adams4Nicole L. Daly5Juan Fernandes Tajes6Giuseppe N. Giordano7Paul W. Franks8Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Department of Clinical Sciences, Clinical Research Centre, Lund University, Skåne University HospitalGenetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Department of Clinical Sciences, Clinical Research Centre, Lund University, Skåne University HospitalGenetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Department of Clinical Sciences, Clinical Research Centre, Lund University, Skåne University HospitalRegulatory Affairs Intelligence, Novo Nordisk A/SRegulatory Affairs—Neuroscience and Cardiovascular Metabolism, JanssenRegulatory Affairs—Neuroscience and Cardiovascular Metabolism, JanssenGenetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Department of Clinical Sciences, Clinical Research Centre, Lund University, Skåne University HospitalGenetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Department of Clinical Sciences, Clinical Research Centre, Lund University, Skåne University HospitalGenetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Department of Clinical Sciences, Clinical Research Centre, Lund University, Skåne University HospitalPrediabetes has been associated with diabetes complications, but these relationships may be confounded. Here the authors show, using genetic data in causal inference analyses, that prediabetes raises risk of coronary heart disease, but not other diabetes complications.https://doi.org/10.1038/s41467-020-18386-9 |
| spellingShingle | Pascal M. Mutie Hugo Pomares-Millan Naeimeh Atabaki-Pasdar Nina Jordan Rachel Adams Nicole L. Daly Juan Fernandes Tajes Giuseppe N. Giordano Paul W. Franks An investigation of causal relationships between prediabetes and vascular complications Nature Communications |
| title | An investigation of causal relationships between prediabetes and vascular complications |
| title_full | An investigation of causal relationships between prediabetes and vascular complications |
| title_fullStr | An investigation of causal relationships between prediabetes and vascular complications |
| title_full_unstemmed | An investigation of causal relationships between prediabetes and vascular complications |
| title_short | An investigation of causal relationships between prediabetes and vascular complications |
| title_sort | investigation of causal relationships between prediabetes and vascular complications |
| url | https://doi.org/10.1038/s41467-020-18386-9 |
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