Neurobehavioral and neurobiochemical changes in arsenic treated male mice
Arsenic is an element that raises much concern from the both environmental and human health. The effects of As on learning behavior, neurotransmitters, and oxidative stress indicators were studied in male Swiss white mice. The purpose of this study was to explore into the preliminary work described...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-07-01
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| Series: | Journal of King Saud University: Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1018364722002506 |
| _version_ | 1818214252266127360 |
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| author | Gasem Abu-Taweel |
| author_facet | Gasem Abu-Taweel |
| author_sort | Gasem Abu-Taweel |
| collection | DOAJ |
| description | Arsenic is an element that raises much concern from the both environmental and human health. The effects of As on learning behavior, neurotransmitters, and oxidative stress indicators were studied in male Swiss white mice. The purpose of this study was to explore into the preliminary work described concerning memory, biochemical changes, and learning impairment in mice exposed to arsenic. The study results in the Shuttle box, Water-maze, T-Maze tests and body weight measurements, As-treated males demonstrated decreased body weight and learning behavior. Dopamine, DA, serotonin, 5-HA, and cholinesterase, AchE levels were all decreased. When compared to the control, GSH and the enzymes GST, CAT, and SOD activity were decreased, while TBARS was raised. This study concludes as the essential reasons that explain the causes of As influence on learning and other data, based on the results collected and other previous studies in this field. In general, additional research is required to determine As negative effects on various elements of human and animal health. |
| first_indexed | 2024-12-12T06:17:14Z |
| format | Article |
| id | doaj.art-6067b844da444d75b73a732bc1aeef31 |
| institution | Directory Open Access Journal |
| issn | 1018-3647 |
| language | English |
| last_indexed | 2024-12-12T06:17:14Z |
| publishDate | 2022-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of King Saud University: Science |
| spelling | doaj.art-6067b844da444d75b73a732bc1aeef312022-12-22T00:35:00ZengElsevierJournal of King Saud University: Science1018-36472022-07-01345102069Neurobehavioral and neurobiochemical changes in arsenic treated male miceGasem Abu-Taweel0Corresponding author.; Department of Biology, College of Sciences, Jazan University, P.O. Box 2079, Jazan 45142, Saudi ArabiaArsenic is an element that raises much concern from the both environmental and human health. The effects of As on learning behavior, neurotransmitters, and oxidative stress indicators were studied in male Swiss white mice. The purpose of this study was to explore into the preliminary work described concerning memory, biochemical changes, and learning impairment in mice exposed to arsenic. The study results in the Shuttle box, Water-maze, T-Maze tests and body weight measurements, As-treated males demonstrated decreased body weight and learning behavior. Dopamine, DA, serotonin, 5-HA, and cholinesterase, AchE levels were all decreased. When compared to the control, GSH and the enzymes GST, CAT, and SOD activity were decreased, while TBARS was raised. This study concludes as the essential reasons that explain the causes of As influence on learning and other data, based on the results collected and other previous studies in this field. In general, additional research is required to determine As negative effects on various elements of human and animal health.http://www.sciencedirect.com/science/article/pii/S1018364722002506Arsenic (As)Learning behaviorShuttle boxWater mazeMiceNeurotransmitters |
| spellingShingle | Gasem Abu-Taweel Neurobehavioral and neurobiochemical changes in arsenic treated male mice Journal of King Saud University: Science Arsenic (As) Learning behavior Shuttle box Water maze Mice Neurotransmitters |
| title | Neurobehavioral and neurobiochemical changes in arsenic treated male mice |
| title_full | Neurobehavioral and neurobiochemical changes in arsenic treated male mice |
| title_fullStr | Neurobehavioral and neurobiochemical changes in arsenic treated male mice |
| title_full_unstemmed | Neurobehavioral and neurobiochemical changes in arsenic treated male mice |
| title_short | Neurobehavioral and neurobiochemical changes in arsenic treated male mice |
| title_sort | neurobehavioral and neurobiochemical changes in arsenic treated male mice |
| topic | Arsenic (As) Learning behavior Shuttle box Water maze Mice Neurotransmitters |
| url | http://www.sciencedirect.com/science/article/pii/S1018364722002506 |
| work_keys_str_mv | AT gasemabutaweel neurobehavioralandneurobiochemicalchangesinarsenictreatedmalemice |