Prognostic Value of Cardiac Troponin I in Patients with Ventricular Tachyarrhythmias
Besides the diagnostic role in acute myocardial infarction, cardiac troponin I levels (cTNI) may be increased in various other clinical conditions, including heart failure, valvular heart disease and sepsis. However, limited data are available regarding the prognostic role of cTNI in the setting of...
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MDPI AG
2022-05-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/11/2987 |
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| author | Ibrahim Akin Michael Behnes Julian Müller Jan Forner Mohammad Abumayyaleh Kambis Mashayekhi Muharrem Akin Thomas Bertsch Kathrin Weidner Jonas Rusnak Dirk Große Meininghaus Maximilian Kittel Tobias Schupp |
| author_facet | Ibrahim Akin Michael Behnes Julian Müller Jan Forner Mohammad Abumayyaleh Kambis Mashayekhi Muharrem Akin Thomas Bertsch Kathrin Weidner Jonas Rusnak Dirk Große Meininghaus Maximilian Kittel Tobias Schupp |
| author_sort | Ibrahim Akin |
| collection | DOAJ |
| description | Besides the diagnostic role in acute myocardial infarction, cardiac troponin I levels (cTNI) may be increased in various other clinical conditions, including heart failure, valvular heart disease and sepsis. However, limited data are available regarding the prognostic role of cTNI in the setting of ventricular tachyarrhythmias. Therefore, the present study sought to assess the prognostic impact of cTNI in patients with ventricular tachyarrhythmias (i.e., ventricular tachycardia (VT) and fibrillation (VF)) on admission. A large retrospective registry was used, including all consecutive patients presenting with ventricular tachyarrhythmias from 2002 to 2015. The prognostic impact of elevated cTNI levels was investigated for 30-day all-cause mortality (i.e., primary endpoint) using Kaplan–Meier, receiver operating characteristic (ROC), multivariable Cox regression analyses and propensity score matching. From a total of 1104 patients with ventricular tachyarrhythmias and available cTNI levels on admission, 46% were admitted with VT and 54% with VF. At 30 days, high cTNI was associated with the primary endpoint (40% vs. 22%; log rank <i>p</i> = 0.001; HR = 2.004; 95% CI 1.603–2.505; <i>p</i> = 0.001), which was still evident after multivariable adjustment and propensity score matching (30% vs. 18%; log rank <i>p</i> = 0.003; HR = 1.729; 95% CI 1.184–2.525; <i>p</i> = 0.005). Significant discrimination of the primary endpoint was especially evident in VT patients (area under the curve (AUC) 0.734; 95% CI 0.645–0.823; <i>p</i> = 0.001). In contrast, secondary endpoints, including all-cause mortality at 30 months and a composite arrhythmic endpoint, were not affected by cTNI levels. The risk of cardiac rehospitalization was lower in patients with high cTNI, which was no longer observed after propensity score matching. In conclusion, high cTNI levels were associated with increased risk of all-cause mortality at 30 days in patients presenting with ventricular tachyarrhythmias. |
| first_indexed | 2024-03-10T01:12:10Z |
| format | Article |
| id | doaj.art-6067ede161624dadbda3a724b640bc96 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T01:12:10Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
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| series | Journal of Clinical Medicine |
| spelling | doaj.art-6067ede161624dadbda3a724b640bc962023-11-23T14:14:54ZengMDPI AGJournal of Clinical Medicine2077-03832022-05-011111298710.3390/jcm11112987Prognostic Value of Cardiac Troponin I in Patients with Ventricular TachyarrhythmiasIbrahim Akin0Michael Behnes1Julian Müller2Jan Forner3Mohammad Abumayyaleh4Kambis Mashayekhi5Muharrem Akin6Thomas Bertsch7Kathrin Weidner8Jonas Rusnak9Dirk Große Meininghaus10Maximilian Kittel11Tobias Schupp12First Department of Medicine, University Medical Centre Mannheim (UMM), Faculty of Medicine Mannheim, University of Heidelberg, 68167 Mannheim, GermanyFirst Department of Medicine, University Medical Centre Mannheim (UMM), Faculty of Medicine Mannheim, University of Heidelberg, 68167 Mannheim, GermanyClinic for Interventional Electrophysiology, Heart Centre Bad Neustadt, 97616 Bad Neustadt a. d. Saale, GermanyFirst Department of Medicine, University Medical Centre Mannheim (UMM), Faculty of Medicine Mannheim, University of Heidelberg, 68167 Mannheim, GermanyFirst Department of Medicine, University Medical Centre Mannheim (UMM), Faculty of Medicine Mannheim, University of Heidelberg, 68167 Mannheim, GermanyDepartment of Internal Medicine and Cardiology, Mediclin Heart Centre Lahr, 77933 Lahr, GermanyDepartment of Cardiology and Angiology, Hannover Medical School, 30625 Hannover, GermanyInstitute of Clinical Chemistry, Laboratory Medicine and Transfusion Medicine, Nuremberg General Hospital, Paracelsus Medical University, 90419 Nuremberg, GermanyFirst Department of Medicine, University Medical Centre Mannheim (UMM), Faculty of Medicine Mannheim, University of Heidelberg, 68167 Mannheim, GermanyFirst Department of Medicine, University Medical Centre Mannheim (UMM), Faculty of Medicine Mannheim, University of Heidelberg, 68167 Mannheim, GermanyDepartment of Cardiology, Carl-Thiem-Klinikum Cottbus, 03048 Cottbus, GermanyInstitute for Clinical Chemistry, Faculty of Medicine Mannheim, Heidelberg University, 68167 Mannheim, GermanyFirst Department of Medicine, University Medical Centre Mannheim (UMM), Faculty of Medicine Mannheim, University of Heidelberg, 68167 Mannheim, GermanyBesides the diagnostic role in acute myocardial infarction, cardiac troponin I levels (cTNI) may be increased in various other clinical conditions, including heart failure, valvular heart disease and sepsis. However, limited data are available regarding the prognostic role of cTNI in the setting of ventricular tachyarrhythmias. Therefore, the present study sought to assess the prognostic impact of cTNI in patients with ventricular tachyarrhythmias (i.e., ventricular tachycardia (VT) and fibrillation (VF)) on admission. A large retrospective registry was used, including all consecutive patients presenting with ventricular tachyarrhythmias from 2002 to 2015. The prognostic impact of elevated cTNI levels was investigated for 30-day all-cause mortality (i.e., primary endpoint) using Kaplan–Meier, receiver operating characteristic (ROC), multivariable Cox regression analyses and propensity score matching. From a total of 1104 patients with ventricular tachyarrhythmias and available cTNI levels on admission, 46% were admitted with VT and 54% with VF. At 30 days, high cTNI was associated with the primary endpoint (40% vs. 22%; log rank <i>p</i> = 0.001; HR = 2.004; 95% CI 1.603–2.505; <i>p</i> = 0.001), which was still evident after multivariable adjustment and propensity score matching (30% vs. 18%; log rank <i>p</i> = 0.003; HR = 1.729; 95% CI 1.184–2.525; <i>p</i> = 0.005). Significant discrimination of the primary endpoint was especially evident in VT patients (area under the curve (AUC) 0.734; 95% CI 0.645–0.823; <i>p</i> = 0.001). In contrast, secondary endpoints, including all-cause mortality at 30 months and a composite arrhythmic endpoint, were not affected by cTNI levels. The risk of cardiac rehospitalization was lower in patients with high cTNI, which was no longer observed after propensity score matching. In conclusion, high cTNI levels were associated with increased risk of all-cause mortality at 30 days in patients presenting with ventricular tachyarrhythmias.https://www.mdpi.com/2077-0383/11/11/2987ventricular tachyarrhythmiascardiac troponin Ibiomarkerssudden cardiac deathcoronary artery disease |
| spellingShingle | Ibrahim Akin Michael Behnes Julian Müller Jan Forner Mohammad Abumayyaleh Kambis Mashayekhi Muharrem Akin Thomas Bertsch Kathrin Weidner Jonas Rusnak Dirk Große Meininghaus Maximilian Kittel Tobias Schupp Prognostic Value of Cardiac Troponin I in Patients with Ventricular Tachyarrhythmias Journal of Clinical Medicine ventricular tachyarrhythmias cardiac troponin I biomarkers sudden cardiac death coronary artery disease |
| title | Prognostic Value of Cardiac Troponin I in Patients with Ventricular Tachyarrhythmias |
| title_full | Prognostic Value of Cardiac Troponin I in Patients with Ventricular Tachyarrhythmias |
| title_fullStr | Prognostic Value of Cardiac Troponin I in Patients with Ventricular Tachyarrhythmias |
| title_full_unstemmed | Prognostic Value of Cardiac Troponin I in Patients with Ventricular Tachyarrhythmias |
| title_short | Prognostic Value of Cardiac Troponin I in Patients with Ventricular Tachyarrhythmias |
| title_sort | prognostic value of cardiac troponin i in patients with ventricular tachyarrhythmias |
| topic | ventricular tachyarrhythmias cardiac troponin I biomarkers sudden cardiac death coronary artery disease |
| url | https://www.mdpi.com/2077-0383/11/11/2987 |
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