The Intricate Interplay between Epigenetic Events, Alternative Splicing and Noncoding RNA Deregulation in Colorectal Cancer
Colorectal cancer (CRC) results from a transformation of colonic epithelial cells into adenocarcinoma cells due to genetic and epigenetic instabilities, alongside remodelling of the surrounding stromal tumour microenvironment. Epithelial-specific epigenetic variations escorting this process include...
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| Format: | Article |
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MDPI AG
2019-08-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/8/8/929 |
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| author | Raheleh Amirkhah Hojjat Naderi-Meshkin Jaynish S. Shah Philip D. Dunne Ulf Schmitz |
| author_facet | Raheleh Amirkhah Hojjat Naderi-Meshkin Jaynish S. Shah Philip D. Dunne Ulf Schmitz |
| author_sort | Raheleh Amirkhah |
| collection | DOAJ |
| description | Colorectal cancer (CRC) results from a transformation of colonic epithelial cells into adenocarcinoma cells due to genetic and epigenetic instabilities, alongside remodelling of the surrounding stromal tumour microenvironment. Epithelial-specific epigenetic variations escorting this process include chromatin remodelling, histone modifications and aberrant DNA methylation, which influence gene expression, alternative splicing and function of non-coding RNA. In this review, we first highlight epigenetic modulators, modifiers and mediators in CRC, then we elaborate on causes and consequences of epigenetic alterations in CRC pathogenesis alongside an appraisal of the complex feedback mechanisms realized through alternative splicing and non-coding RNA regulation. An emphasis in our review is put on how this intricate network of epigenetic and post-transcriptional gene regulation evolves during the initiation, progression and metastasis formation in CRC. |
| first_indexed | 2024-03-12T10:21:40Z |
| format | Article |
| id | doaj.art-6068b69e160a4b41bbace9f8d91805ff |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T10:21:40Z |
| publishDate | 2019-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-6068b69e160a4b41bbace9f8d91805ff2023-09-02T10:04:55ZengMDPI AGCells2073-44092019-08-018892910.3390/cells8080929cells8080929The Intricate Interplay between Epigenetic Events, Alternative Splicing and Noncoding RNA Deregulation in Colorectal CancerRaheleh Amirkhah0Hojjat Naderi-Meshkin1Jaynish S. Shah2Philip D. Dunne3Ulf Schmitz4Centre for Cancer Research and Cell Biology, Queen’s University Belfast, Belfast BT9 7AE, UKNastaran Center for Cancer Prevention (NCCP), Mashhad 9185765476, IranGene & Stem Cell Therapy Program Centenary Institute, The University of Sydney, Camperdown, NSW 2050, AustraliaCentre for Cancer Research and Cell Biology, Queen’s University Belfast, Belfast BT9 7AE, UKGene & Stem Cell Therapy Program Centenary Institute, The University of Sydney, Camperdown, NSW 2050, AustraliaColorectal cancer (CRC) results from a transformation of colonic epithelial cells into adenocarcinoma cells due to genetic and epigenetic instabilities, alongside remodelling of the surrounding stromal tumour microenvironment. Epithelial-specific epigenetic variations escorting this process include chromatin remodelling, histone modifications and aberrant DNA methylation, which influence gene expression, alternative splicing and function of non-coding RNA. In this review, we first highlight epigenetic modulators, modifiers and mediators in CRC, then we elaborate on causes and consequences of epigenetic alterations in CRC pathogenesis alongside an appraisal of the complex feedback mechanisms realized through alternative splicing and non-coding RNA regulation. An emphasis in our review is put on how this intricate network of epigenetic and post-transcriptional gene regulation evolves during the initiation, progression and metastasis formation in CRC.https://www.mdpi.com/2073-4409/8/8/929chromatin remodellinghistone modificationsaberrant DNA methylationlong non-coding RNAmicroRNA |
| spellingShingle | Raheleh Amirkhah Hojjat Naderi-Meshkin Jaynish S. Shah Philip D. Dunne Ulf Schmitz The Intricate Interplay between Epigenetic Events, Alternative Splicing and Noncoding RNA Deregulation in Colorectal Cancer Cells chromatin remodelling histone modifications aberrant DNA methylation long non-coding RNA microRNA |
| title | The Intricate Interplay between Epigenetic Events, Alternative Splicing and Noncoding RNA Deregulation in Colorectal Cancer |
| title_full | The Intricate Interplay between Epigenetic Events, Alternative Splicing and Noncoding RNA Deregulation in Colorectal Cancer |
| title_fullStr | The Intricate Interplay between Epigenetic Events, Alternative Splicing and Noncoding RNA Deregulation in Colorectal Cancer |
| title_full_unstemmed | The Intricate Interplay between Epigenetic Events, Alternative Splicing and Noncoding RNA Deregulation in Colorectal Cancer |
| title_short | The Intricate Interplay between Epigenetic Events, Alternative Splicing and Noncoding RNA Deregulation in Colorectal Cancer |
| title_sort | intricate interplay between epigenetic events alternative splicing and noncoding rna deregulation in colorectal cancer |
| topic | chromatin remodelling histone modifications aberrant DNA methylation long non-coding RNA microRNA |
| url | https://www.mdpi.com/2073-4409/8/8/929 |
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