Intimate functional interactions between TGS1 and the Smn complex revealed by an analysis of the Drosophila eye development.

Intimate functional interactions between TGS1 and the Smn complex revealed by an analysis of the Drosophila eye development.

Trimethylguanosine synthase 1 (TGS1) is a conserved enzyme that mediates formation of the trimethylguanosine cap on several RNAs, including snRNAs and telomerase RNA. Previous studies have shown that TGS1 binds the Survival Motor Neuron (SMN) protein, whose deficiency causes spinal muscular atrophy...

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Main Authors: Paolo Maccallini, Francesca Bavasso, Livia Scatolini, Elisabetta Bucciarelli, Gemma Noviello, Veronica Lisi, Valeria Palumbo, Simone D'Angeli, Stefano Cacchione, Giovanni Cenci, Laura Ciapponi, James G Wakefield, Maurizio Gatti, Grazia Daniela Raffa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-05-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1008815

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