Dystonia-like behaviors and impaired sensory–motor integration following neurotoxic lesion of the pedunculopontine tegmental nucleus in mice

Dystonia-like behaviors and impaired sensory–motor integration following neurotoxic lesion of the pedunculopontine tegmental nucleus in mice

IntroductionThe pedunculopontine nucleus (PPTg) is a vital interface between the basal ganglia and cerebellum, participating in modulation of the locomotion and muscle tone. Pathological changes of the PPTg have been reported in patients and animal models of dystonia, while its effect and mechanism...

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Bibliographic Details
Main Authors: Jun-Hui Su, Yao-Wen Hu, Yun-Ping Song, Yi Yang, Ruo-Yu Li, Kai-Ge Zhou, Ling Hu, Xin-Hua Wan, Fei Teng, Ling-Jing Jin
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Neurology
Subjects:
pedunculopontine nucleus
dystonia
sensory-motor integration
motor performance
reticular formation
striatal pathways
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2023.1102837/full

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