The Naples Prognostic Score Is a Useful Tool to Assess Surgical Treatment in Non-Small Cell Lung Cancer
Different prognostic scores have been applied to identify patients with non-small cell lung cancer who have a higher probability of poor outcomes. In this study, we evaluated whether the Naples Prognostic Score, a novel index that considers both inflammatory and nutritional values, was associated wi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/24/3641 |
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| author | Stefano Elia Alexandro Patirelis Georgia Hardavella Antonella Santone Federica Carlea Eugenio Pompeo |
| author_facet | Stefano Elia Alexandro Patirelis Georgia Hardavella Antonella Santone Federica Carlea Eugenio Pompeo |
| author_sort | Stefano Elia |
| collection | DOAJ |
| description | Different prognostic scores have been applied to identify patients with non-small cell lung cancer who have a higher probability of poor outcomes. In this study, we evaluated whether the Naples Prognostic Score, a novel index that considers both inflammatory and nutritional values, was associated with long-term survival. This study presents a retrospective propensity score matching analysis of patients who underwent curative surgery for non-small cell lung cancer from January 2016 to December 2021. The score considered the following four pre-operative parameters: the neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, serum albumin, and total cholesterol. The Kaplan–Meier method and Cox regression analysis were performed to evaluate the relationship between the score and disease-free survival, overall survival, and cancer-related survival. A total of 260 patients were selected for the study, though this was reduced to 154 after propensity score matching. Post-propensity Kaplan–Meier analysis showed a significant correlation between the Naples Prognostic Score, overall survival (<i>p</i> = 0.018), and cancer-related survival (<i>p</i> = 0.007). Multivariate Cox regression analysis further validated the score as an independent prognostic indicator for both types of survival (<i>p</i> = 0.007 and <i>p</i> = 0.010, respectively). The Naples Prognostic Score proved to be an easily achievable prognostic factor of long-term survival in patients with non-small cell lung cancer after surgical treatment. |
| first_indexed | 2024-03-08T20:51:43Z |
| format | Article |
| id | doaj.art-606a48924e8b40a7a49ad74968df8e12 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-08T20:51:43Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-606a48924e8b40a7a49ad74968df8e122023-12-22T14:03:10ZengMDPI AGDiagnostics2075-44182023-12-011324364110.3390/diagnostics13243641The Naples Prognostic Score Is a Useful Tool to Assess Surgical Treatment in Non-Small Cell Lung CancerStefano Elia0Alexandro Patirelis1Georgia Hardavella2Antonella Santone3Federica Carlea4Eugenio Pompeo5Department of Medicine and Health Sciences, University of Molise, 86100 Campobasso, ItalyThoracic Surgery Unit, Tor Vergata University Hospital, 00133 Rome, Italy9th Department of Respiratory Medicine, Athens Chest Diseases Hospital Sotiria, 11527 Athens, GreeceDepartment of Medicine and Health Sciences, University of Molise, 86100 Campobasso, ItalyThoracic Surgery Unit, Tor Vergata University Hospital, 00133 Rome, ItalyThoracic Surgery Unit, Tor Vergata University Hospital, 00133 Rome, ItalyDifferent prognostic scores have been applied to identify patients with non-small cell lung cancer who have a higher probability of poor outcomes. In this study, we evaluated whether the Naples Prognostic Score, a novel index that considers both inflammatory and nutritional values, was associated with long-term survival. This study presents a retrospective propensity score matching analysis of patients who underwent curative surgery for non-small cell lung cancer from January 2016 to December 2021. The score considered the following four pre-operative parameters: the neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, serum albumin, and total cholesterol. The Kaplan–Meier method and Cox regression analysis were performed to evaluate the relationship between the score and disease-free survival, overall survival, and cancer-related survival. A total of 260 patients were selected for the study, though this was reduced to 154 after propensity score matching. Post-propensity Kaplan–Meier analysis showed a significant correlation between the Naples Prognostic Score, overall survival (<i>p</i> = 0.018), and cancer-related survival (<i>p</i> = 0.007). Multivariate Cox regression analysis further validated the score as an independent prognostic indicator for both types of survival (<i>p</i> = 0.007 and <i>p</i> = 0.010, respectively). The Naples Prognostic Score proved to be an easily achievable prognostic factor of long-term survival in patients with non-small cell lung cancer after surgical treatment.https://www.mdpi.com/2075-4418/13/24/3641non-small cell lung cancerprognosisNaples Prognostic Scorethoracic surgerysurvivalprognostic score |
| spellingShingle | Stefano Elia Alexandro Patirelis Georgia Hardavella Antonella Santone Federica Carlea Eugenio Pompeo The Naples Prognostic Score Is a Useful Tool to Assess Surgical Treatment in Non-Small Cell Lung Cancer Diagnostics non-small cell lung cancer prognosis Naples Prognostic Score thoracic surgery survival prognostic score |
| title | The Naples Prognostic Score Is a Useful Tool to Assess Surgical Treatment in Non-Small Cell Lung Cancer |
| title_full | The Naples Prognostic Score Is a Useful Tool to Assess Surgical Treatment in Non-Small Cell Lung Cancer |
| title_fullStr | The Naples Prognostic Score Is a Useful Tool to Assess Surgical Treatment in Non-Small Cell Lung Cancer |
| title_full_unstemmed | The Naples Prognostic Score Is a Useful Tool to Assess Surgical Treatment in Non-Small Cell Lung Cancer |
| title_short | The Naples Prognostic Score Is a Useful Tool to Assess Surgical Treatment in Non-Small Cell Lung Cancer |
| title_sort | naples prognostic score is a useful tool to assess surgical treatment in non small cell lung cancer |
| topic | non-small cell lung cancer prognosis Naples Prognostic Score thoracic surgery survival prognostic score |
| url | https://www.mdpi.com/2075-4418/13/24/3641 |
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