ADJUVANTS OF INFLUENZA VACCINES: NEW POSSIBILITIES OF USING SULPHATED POLYSACCHARIDES FROM MARINE BROWN ALGAE
The review article presents the characteristics of the main adjuvant groups (mineral salts of aluminum, synthetic squalene-based adjuvants - MF59 and AS03, CpG-oligodeoxynucleotides, virosomes, polyoxidonium, sovidone) included in the licensed influenza vaccine. The main mechanisms of adjuvant actio...
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| Format: | Article |
| Language: | English |
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Central Research Institute for Epidemiology
2019-02-01
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| Series: | Вопросы вирусологии |
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| Online Access: | https://virusjour.crie.ru/jour/article/viewFile/227/130 |
| _version_ | 1797782274796683264 |
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| author | T. A. Kuznetsova E. V. Persiyanova T. S. Zaporozhets N. N. Besednova |
| author_facet | T. A. Kuznetsova E. V. Persiyanova T. S. Zaporozhets N. N. Besednova |
| author_sort | T. A. Kuznetsova |
| collection | DOAJ |
| description | The review article presents the characteristics of the main adjuvant groups (mineral salts of aluminum, synthetic squalene-based adjuvants - MF59 and AS03, CpG-oligodeoxynucleotides, virosomes, polyoxidonium, sovidone) included in the licensed influenza vaccine. The main mechanisms of adjuvant action, advantages and disadvantages of these adjuvants are shown. The vaccines adjuvants in the phase of experimental studies and clinical trials (ISCOMs, Advax™, chitosan) are described too. Particular attention is paid to sulfated polysaccharides (fucoidans) from marine brown algae as vaccine adjuvants. Numerous results of their application in compositions of experimental vaccines are presented. The prospects of sulfated polysaccharides using in the design of influenza vaccines are estimated. These prospects are determined by high biocompatibility, low toxicity and good tolerance of the human body to fucoidans, as well as mechanisms of their adjuvant activity. Sulfated polysaccharides are agonists of toll-like receptors of innate immunity cells and powerful inducers of the cellular and humoral immune response, which is important for the development of influenza vaccines. The review is based on the information presented in the bibliographic and abstract databases of scientific publications, search engines and publishers: RSCI, Web of Science, Scopus, MEDLINE, Google Scholar, PubMed, Springer Nature, Elsevier and others. |
| first_indexed | 2024-03-13T00:08:40Z |
| format | Article |
| id | doaj.art-606b36975b0f43c58ff0f61d65b69f48 |
| institution | Directory Open Access Journal |
| issn | 0507-4088 2411-2097 |
| language | English |
| last_indexed | 2024-03-13T00:08:40Z |
| publishDate | 2019-02-01 |
| publisher | Central Research Institute for Epidemiology |
| record_format | Article |
| series | Вопросы вирусологии |
| spelling | doaj.art-606b36975b0f43c58ff0f61d65b69f482023-07-12T19:59:20ZengCentral Research Institute for EpidemiologyВопросы вирусологии0507-40882411-20972019-02-0164151110.18821/0507-4088-2019-64-1-5-11207ADJUVANTS OF INFLUENZA VACCINES: NEW POSSIBILITIES OF USING SULPHATED POLYSACCHARIDES FROM MARINE BROWN ALGAET. A. Kuznetsova0E. V. Persiyanova1T. S. Zaporozhets2N. N. Besednova3Research Somov Institute of Epidemiology and MicrobiologyResearch Somov Institute of Epidemiology and MicrobiologyResearch Somov Institute of Epidemiology and MicrobiologyResearch Somov Institute of Epidemiology and MicrobiologyThe review article presents the characteristics of the main adjuvant groups (mineral salts of aluminum, synthetic squalene-based adjuvants - MF59 and AS03, CpG-oligodeoxynucleotides, virosomes, polyoxidonium, sovidone) included in the licensed influenza vaccine. The main mechanisms of adjuvant action, advantages and disadvantages of these adjuvants are shown. The vaccines adjuvants in the phase of experimental studies and clinical trials (ISCOMs, Advax™, chitosan) are described too. Particular attention is paid to sulfated polysaccharides (fucoidans) from marine brown algae as vaccine adjuvants. Numerous results of their application in compositions of experimental vaccines are presented. The prospects of sulfated polysaccharides using in the design of influenza vaccines are estimated. These prospects are determined by high biocompatibility, low toxicity and good tolerance of the human body to fucoidans, as well as mechanisms of their adjuvant activity. Sulfated polysaccharides are agonists of toll-like receptors of innate immunity cells and powerful inducers of the cellular and humoral immune response, which is important for the development of influenza vaccines. The review is based on the information presented in the bibliographic and abstract databases of scientific publications, search engines and publishers: RSCI, Web of Science, Scopus, MEDLINE, Google Scholar, PubMed, Springer Nature, Elsevier and others.https://virusjour.crie.ru/jour/article/viewFile/227/130reviewadjuvantsvaccinesinfluenza virussulfated polysaccharidesfucoidans |
| spellingShingle | T. A. Kuznetsova E. V. Persiyanova T. S. Zaporozhets N. N. Besednova ADJUVANTS OF INFLUENZA VACCINES: NEW POSSIBILITIES OF USING SULPHATED POLYSACCHARIDES FROM MARINE BROWN ALGAE Вопросы вирусологии review adjuvants vaccines influenza virus sulfated polysaccharides fucoidans |
| title | ADJUVANTS OF INFLUENZA VACCINES: NEW POSSIBILITIES OF USING SULPHATED POLYSACCHARIDES FROM MARINE BROWN ALGAE |
| title_full | ADJUVANTS OF INFLUENZA VACCINES: NEW POSSIBILITIES OF USING SULPHATED POLYSACCHARIDES FROM MARINE BROWN ALGAE |
| title_fullStr | ADJUVANTS OF INFLUENZA VACCINES: NEW POSSIBILITIES OF USING SULPHATED POLYSACCHARIDES FROM MARINE BROWN ALGAE |
| title_full_unstemmed | ADJUVANTS OF INFLUENZA VACCINES: NEW POSSIBILITIES OF USING SULPHATED POLYSACCHARIDES FROM MARINE BROWN ALGAE |
| title_short | ADJUVANTS OF INFLUENZA VACCINES: NEW POSSIBILITIES OF USING SULPHATED POLYSACCHARIDES FROM MARINE BROWN ALGAE |
| title_sort | adjuvants of influenza vaccines new possibilities of using sulphated polysaccharides from marine brown algae |
| topic | review adjuvants vaccines influenza virus sulfated polysaccharides fucoidans |
| url | https://virusjour.crie.ru/jour/article/viewFile/227/130 |
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