Near-Infrared Responsive Phase-Shifted Nanoparticles for Magnetically Targeted MR/US Imaging and Photothermal Therapy of Cancer
Accurate diagnosis, providing guidance for early treatment, can greatly improve the survival rate of cancer patients. However, there are still some difficulties with the existing diagnostic technology and early treatment methods. Here, near-infrared responsive phase-shifted nanoparticles (NRPNs) hav...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-11-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2020.599107/full |
| _version_ | 1811294682280361984 |
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| author | Yan Xu Yan Xu Wang Li Wang Li Sijie Chen Sijie Chen Biying Huang Biying Huang Wenjing Pei Wenjing Pei Chengcheng Niu Chengcheng Niu |
| author_facet | Yan Xu Yan Xu Wang Li Wang Li Sijie Chen Sijie Chen Biying Huang Biying Huang Wenjing Pei Wenjing Pei Chengcheng Niu Chengcheng Niu |
| author_sort | Yan Xu |
| collection | DOAJ |
| description | Accurate diagnosis, providing guidance for early treatment, can greatly improve the survival rate of cancer patients. However, there are still some difficulties with the existing diagnostic technology and early treatment methods. Here, near-infrared responsive phase-shifted nanoparticles (NRPNs) have been designed for magnetically targeted MR/US imaging and photothermal therapy of tumors. In this study, we fabricated a multifunctional polymer nanoparticle encapsulating indocyanine green (ICG), magnetic Fe3O4 nanoparticles and perfluoropentane (PFP). Under laser irradiation, the NRPNs, which trigger a phase-shifted expansion effect due to the quick conversion from light to heat by ICG and Fe3O4, can be used for ultrasound (US) imaging. At the same time, such nanoparticles can kill cancer cells via photothermal therapy (PTT). As a kind of negative enhancement agent, magnetic Fe3O4 nanoparticles in NRPNs showed high spatial resolution in MR imaging. Moreover, with the help of the magnetic field, the NRPNs nanoparticles showed high cellular uptake and high tumor accumulation, indicating their magnetic targeting property without biosafety concerns. Therefore, we present a strategy for magnetically targeted MR/US imaging guided photothermal therapy for the accurate diagnosis and efficient treatment of tumors. |
| first_indexed | 2024-04-13T05:21:04Z |
| format | Article |
| id | doaj.art-606b97500f2440dd9d555e6122f98306 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-13T05:21:04Z |
| publishDate | 2020-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-606b97500f2440dd9d555e6122f983062022-12-22T03:00:44ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852020-11-01810.3389/fbioe.2020.599107599107Near-Infrared Responsive Phase-Shifted Nanoparticles for Magnetically Targeted MR/US Imaging and Photothermal Therapy of CancerYan Xu0Yan Xu1Wang Li2Wang Li3Sijie Chen4Sijie Chen5Biying Huang6Biying Huang7Wenjing Pei8Wenjing Pei9Chengcheng Niu10Chengcheng Niu11Department of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, ChinaResearch Center of Ultrasonography, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, ChinaResearch Center of Ultrasonography, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, ChinaResearch Center of Ultrasonography, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, ChinaResearch Center of Ultrasonography, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, ChinaResearch Center of Ultrasonography, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, ChinaResearch Center of Ultrasonography, The Second Xiangya Hospital, Central South University, Changsha, ChinaAccurate diagnosis, providing guidance for early treatment, can greatly improve the survival rate of cancer patients. However, there are still some difficulties with the existing diagnostic technology and early treatment methods. Here, near-infrared responsive phase-shifted nanoparticles (NRPNs) have been designed for magnetically targeted MR/US imaging and photothermal therapy of tumors. In this study, we fabricated a multifunctional polymer nanoparticle encapsulating indocyanine green (ICG), magnetic Fe3O4 nanoparticles and perfluoropentane (PFP). Under laser irradiation, the NRPNs, which trigger a phase-shifted expansion effect due to the quick conversion from light to heat by ICG and Fe3O4, can be used for ultrasound (US) imaging. At the same time, such nanoparticles can kill cancer cells via photothermal therapy (PTT). As a kind of negative enhancement agent, magnetic Fe3O4 nanoparticles in NRPNs showed high spatial resolution in MR imaging. Moreover, with the help of the magnetic field, the NRPNs nanoparticles showed high cellular uptake and high tumor accumulation, indicating their magnetic targeting property without biosafety concerns. Therefore, we present a strategy for magnetically targeted MR/US imaging guided photothermal therapy for the accurate diagnosis and efficient treatment of tumors.https://www.frontiersin.org/articles/10.3389/fbioe.2020.599107/fullmagnetically targetedMR/US imagingperfluorocarbonphase shiftedphotothermal therapy |
| spellingShingle | Yan Xu Yan Xu Wang Li Wang Li Sijie Chen Sijie Chen Biying Huang Biying Huang Wenjing Pei Wenjing Pei Chengcheng Niu Chengcheng Niu Near-Infrared Responsive Phase-Shifted Nanoparticles for Magnetically Targeted MR/US Imaging and Photothermal Therapy of Cancer Frontiers in Bioengineering and Biotechnology magnetically targeted MR/US imaging perfluorocarbon phase shifted photothermal therapy |
| title | Near-Infrared Responsive Phase-Shifted Nanoparticles for Magnetically Targeted MR/US Imaging and Photothermal Therapy of Cancer |
| title_full | Near-Infrared Responsive Phase-Shifted Nanoparticles for Magnetically Targeted MR/US Imaging and Photothermal Therapy of Cancer |
| title_fullStr | Near-Infrared Responsive Phase-Shifted Nanoparticles for Magnetically Targeted MR/US Imaging and Photothermal Therapy of Cancer |
| title_full_unstemmed | Near-Infrared Responsive Phase-Shifted Nanoparticles for Magnetically Targeted MR/US Imaging and Photothermal Therapy of Cancer |
| title_short | Near-Infrared Responsive Phase-Shifted Nanoparticles for Magnetically Targeted MR/US Imaging and Photothermal Therapy of Cancer |
| title_sort | near infrared responsive phase shifted nanoparticles for magnetically targeted mr us imaging and photothermal therapy of cancer |
| topic | magnetically targeted MR/US imaging perfluorocarbon phase shifted photothermal therapy |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2020.599107/full |
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