Safety and efficacy of aged garlic extract in dogs: upregulation of the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway and Nrf2-regulated phase II antioxidant enzymes

Safety and efficacy of aged garlic extract in dogs: upregulation of the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway and Nrf2-regulated phase II antioxidant enzymes

Abstract Background Plants of Allium spp., including garlic (A. sativum) and onions (A. cepa), are known to be oxidatively toxic to canine erythrocytes resulting in Heinz body hemolytic anemia in dogs. In humans, these plants have been used as medicinal agents for multiple diseases since ancient tim...

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Bibliographic Details
Main Authors: Osamu Yamato, Tadamitsu Tsuneyoshi, Mitsuyasu Ushijima, Hiroshi Jikihara, Akira Yabuki
Format: Article
Language:English
Published: BMC 2018-11-01
Series:BMC Veterinary Research
Subjects:
Aged garlic extract (AGE)
Dog
Nuclear factor erythroid 2-related factor 2 (Nrf2)
Phase II antioxidant enzyme
NAD(P)H quinone dehydrogenase 1 (NQO1)
Glutamate-cysteine ligase modifier subunit (GCLM)
Online Access:http://link.springer.com/article/10.1186/s12917-018-1699-2

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