Hepatoid carcinoma of the ovary: A case report and review of the literature
Primary hepatoid carcinoma of the ovary (HCO) is a rare aggressive tumor that typically presents at an advanced stage in postmenopausal women with unilateral or bilateral ovarian masses and elevated AFP and CA125. We report a case of HCO in a 73 year-old woman who presented with abdominal distention...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2015-08-01
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| Series: | Gynecologic Oncology Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352578915000442 |
| _version_ | 1818029369327616000 |
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| author | Laura K. Randolph Maeve K. Hopkins Michael P. Hopkins Daniel A. Wasdahl |
| author_facet | Laura K. Randolph Maeve K. Hopkins Michael P. Hopkins Daniel A. Wasdahl |
| author_sort | Laura K. Randolph |
| collection | DOAJ |
| description | Primary hepatoid carcinoma of the ovary (HCO) is a rare aggressive tumor that typically presents at an advanced stage in postmenopausal women with unilateral or bilateral ovarian masses and elevated AFP and CA125. We report a case of HCO in a 73 year-old woman who presented with abdominal distention, weight loss, and a large lower abdominal mass. Postoperative serum AFP was markedly elevated and trended down with initiation of chemotherapy. Review of the literature revealed thirty-two reported cases with no consensus on histogenesis or consistent immunohistochemical profile other than positive AFP staining in all but one case. Although the optimal treatment has not yet been determined, tumor debulking surgery followed by a platinum and taxane based chemotherapy regimen has shown promise. Both serum AFP and CA125 appear to have prognostic value and can be used to follow response to treatment and screen for recurrence. |
| first_indexed | 2024-12-10T05:18:35Z |
| format | Article |
| id | doaj.art-6070a20e278f48f3a46ead4b18aa8c60 |
| institution | Directory Open Access Journal |
| issn | 2352-5789 |
| language | English |
| last_indexed | 2024-12-10T05:18:35Z |
| publishDate | 2015-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Gynecologic Oncology Reports |
| spelling | doaj.art-6070a20e278f48f3a46ead4b18aa8c602022-12-22T02:00:52ZengElsevierGynecologic Oncology Reports2352-57892015-08-0113C646710.1016/j.gore.2015.06.006Hepatoid carcinoma of the ovary: A case report and review of the literatureLaura K. Randolph0Maeve K. Hopkins1Michael P. Hopkins2Daniel A. Wasdahl3Department of Obstetrics and Gynecology, Aultman Hospital, Northeast Ohio Medical University, 2600 6th St SW, Canton, OH 44708, United StatesDepartment of Obstetrics and Gynecology, Duke University Hospital, 2301 Erwin Rd, Durham, NC 27705, United StatesDepartment of Obstetrics and Gynecology, Aultman Hospital, Northeast Ohio Medical University, 2600 6th St SW, Canton, OH 44708, United StatesDepartment of Pathology, Aultman Hospital, Northeast Ohio Medical University, 2600 6th St. SW, Canton, OH 44708, United StatesPrimary hepatoid carcinoma of the ovary (HCO) is a rare aggressive tumor that typically presents at an advanced stage in postmenopausal women with unilateral or bilateral ovarian masses and elevated AFP and CA125. We report a case of HCO in a 73 year-old woman who presented with abdominal distention, weight loss, and a large lower abdominal mass. Postoperative serum AFP was markedly elevated and trended down with initiation of chemotherapy. Review of the literature revealed thirty-two reported cases with no consensus on histogenesis or consistent immunohistochemical profile other than positive AFP staining in all but one case. Although the optimal treatment has not yet been determined, tumor debulking surgery followed by a platinum and taxane based chemotherapy regimen has shown promise. Both serum AFP and CA125 appear to have prognostic value and can be used to follow response to treatment and screen for recurrence.http://www.sciencedirect.com/science/article/pii/S2352578915000442Hepatoid ovarian carcinomaAlpha-fetoprotein |
| spellingShingle | Laura K. Randolph Maeve K. Hopkins Michael P. Hopkins Daniel A. Wasdahl Hepatoid carcinoma of the ovary: A case report and review of the literature Gynecologic Oncology Reports Hepatoid ovarian carcinoma Alpha-fetoprotein |
| title | Hepatoid carcinoma of the ovary: A case report and review of the literature |
| title_full | Hepatoid carcinoma of the ovary: A case report and review of the literature |
| title_fullStr | Hepatoid carcinoma of the ovary: A case report and review of the literature |
| title_full_unstemmed | Hepatoid carcinoma of the ovary: A case report and review of the literature |
| title_short | Hepatoid carcinoma of the ovary: A case report and review of the literature |
| title_sort | hepatoid carcinoma of the ovary a case report and review of the literature |
| topic | Hepatoid ovarian carcinoma Alpha-fetoprotein |
| url | http://www.sciencedirect.com/science/article/pii/S2352578915000442 |
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