Feasibility of definitive chemoradiation therapy with nedaplatin and 5-fluorouracil in elderly patients with esophageal squamous cell carcinoma: A retrospective study
Purpose: This study was designed to retrospectively analyze the safety and efficacy of chemoradiation therapy with nedaplatin and 5-fluorouracil in elderly patients with esophageal squamous cell carcinoma. Methods and materials: Eligible patients were aged 76 years or older, had a histopathologic di...
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| Format: | Article |
| Language: | English |
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Elsevier
2018-07-01
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| Series: | Advances in Radiation Oncology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452109418300356 |
| _version_ | 1818240647832797184 |
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| author | Akinori Watanabe, MD Chikatoshi Katada, MD, PhD Shouko Komori, MD Hiromitsu Moriya, MD, PhD Keishi Yamashita, MD, PhD Hiroki Harada, MD Mizutomo Azuma, MD, PhD Yuki Kondo, MD Yo Kubota, MD Yasuaki Furue, MD Natsuko Kawanishi, MD Sakiko Yamane, MD Takuya Wada, MD Takafumi Yano, MD Kenji Ishido, MD, PhD Satoshi Tanabe, MD, PhD Kazushige Hayakawa, MD, PhD Wasaburo Koizumi, MD, PhD |
| author_facet | Akinori Watanabe, MD Chikatoshi Katada, MD, PhD Shouko Komori, MD Hiromitsu Moriya, MD, PhD Keishi Yamashita, MD, PhD Hiroki Harada, MD Mizutomo Azuma, MD, PhD Yuki Kondo, MD Yo Kubota, MD Yasuaki Furue, MD Natsuko Kawanishi, MD Sakiko Yamane, MD Takuya Wada, MD Takafumi Yano, MD Kenji Ishido, MD, PhD Satoshi Tanabe, MD, PhD Kazushige Hayakawa, MD, PhD Wasaburo Koizumi, MD, PhD |
| author_sort | Akinori Watanabe, MD |
| collection | DOAJ |
| description | Purpose: This study was designed to retrospectively analyze the safety and efficacy of chemoradiation therapy with nedaplatin and 5-fluorouracil in elderly patients with esophageal squamous cell carcinoma. Methods and materials: Eligible patients were aged 76 years or older, had a histopathologic diagnosis of esophageal squamous cell carcinoma, and were treated at the Kitasato University Hospital between January 2010 and March 2016. Chemotherapy consisted of nedaplatin in an intravenous dose of 90 mg/m2 on day 1 and 5-fluorouracil in an intravenous dose of 800 mg/m2 on days 1 to 5, repeated every 4 weeks for 2 cycles. Radiation therapy consisted of 50.4 Gy in 28 fractions for thoracic tumors and 61.2 Gy for cervical tumors. Results: Twenty-five patients were studied. Patient characteristics were as follows: median age 79 years (range, 76-85 years), clinical stage I/II/III/IV (7/8/8/2, respectively), and surgically resectable/unresectable (17/8, respectively). The completion rates of radiation therapy and chemoradiation therapy were 100% and 84%, respectively. Grade ≥3 acute toxicities included neutropenia (76%), leukopenia (72%), thrombocytopenia (32%), anemia (28%), anorexia (32%), oral mucositis (20%), febrile neutropenia (12%), and esophagitis (8%). Grade ≥3 late toxicities included esophageal stenosis (12%) and pleural effusion (4%). The complete response rate was 64%. In the median follow-up period of 18.9 months, the 1-year overall survival rate was 68%. Conclusions: Definitive chemoradiation therapy with nedaplatin and 5-fluorouracil may be a feasible treatment option for elderly patients with esophageal squamous cell carcinoma. |
| first_indexed | 2024-12-12T13:16:46Z |
| format | Article |
| id | doaj.art-6072a5059f6c4577a687c29d98fe0a58 |
| institution | Directory Open Access Journal |
| issn | 2452-1094 |
| language | English |
| last_indexed | 2024-12-12T13:16:46Z |
| publishDate | 2018-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Advances in Radiation Oncology |
| spelling | doaj.art-6072a5059f6c4577a687c29d98fe0a582022-12-22T00:23:23ZengElsevierAdvances in Radiation Oncology2452-10942018-07-0133305313Feasibility of definitive chemoradiation therapy with nedaplatin and 5-fluorouracil in elderly patients with esophageal squamous cell carcinoma: A retrospective studyAkinori Watanabe, MD0Chikatoshi Katada, MD, PhD1Shouko Komori, MD2Hiromitsu Moriya, MD, PhD3Keishi Yamashita, MD, PhD4Hiroki Harada, MD5Mizutomo Azuma, MD, PhD6Yuki Kondo, MD7Yo Kubota, MD8Yasuaki Furue, MD9Natsuko Kawanishi, MD10Sakiko Yamane, MD11Takuya Wada, MD12Takafumi Yano, MD13Kenji Ishido, MD, PhD14Satoshi Tanabe, MD, PhD15Kazushige Hayakawa, MD, PhD16Wasaburo Koizumi, MD, PhD17Department of Gastroenterology, Kitasato University School of Medicine, Sagamihara, JapanDepartment of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Japan; Corresponding author. Department of Gastroenterology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami, Sagamihara, Kanagawa, 252-0374, Japan.Department of Radiology and Radiation Oncology, Kitasato University School of Medicine, Sagamihara, JapanDepartment of Gastrointestinal Surgery, Kitasato University School of Medicine, Sagamihara, JapanDepartment of Gastrointestinal Surgery, Kitasato University School of Medicine, Sagamihara, JapanDepartment of Gastrointestinal Surgery, Kitasato University School of Medicine, Sagamihara, JapanDepartment of Gastroenterology, Kitasato University School of Medicine, Sagamihara, JapanDepartment of Gastroenterology, Kitasato University School of Medicine, Sagamihara, JapanDepartment of Gastroenterology, Kitasato University School of Medicine, Sagamihara, JapanDepartment of Gastroenterology, Kitasato University School of Medicine, Sagamihara, JapanDepartment of Gastroenterology, Kitasato University School of Medicine, Sagamihara, JapanDepartment of Gastroenterology, Kitasato University School of Medicine, Sagamihara, JapanDepartment of Gastroenterology, Kitasato University School of Medicine, Sagamihara, JapanDepartment of Gastroenterology, Kitasato University School of Medicine, Sagamihara, JapanDepartment of Gastroenterology, Kitasato University School of Medicine, Sagamihara, JapanResearch and Development Center for New Frontier, Kitasato University School of Medicine, Sagamihara, JapanDepartment of Radiology and Radiation Oncology, Kitasato University School of Medicine, Sagamihara, JapanDepartment of Gastroenterology, Kitasato University School of Medicine, Sagamihara, JapanPurpose: This study was designed to retrospectively analyze the safety and efficacy of chemoradiation therapy with nedaplatin and 5-fluorouracil in elderly patients with esophageal squamous cell carcinoma. Methods and materials: Eligible patients were aged 76 years or older, had a histopathologic diagnosis of esophageal squamous cell carcinoma, and were treated at the Kitasato University Hospital between January 2010 and March 2016. Chemotherapy consisted of nedaplatin in an intravenous dose of 90 mg/m2 on day 1 and 5-fluorouracil in an intravenous dose of 800 mg/m2 on days 1 to 5, repeated every 4 weeks for 2 cycles. Radiation therapy consisted of 50.4 Gy in 28 fractions for thoracic tumors and 61.2 Gy for cervical tumors. Results: Twenty-five patients were studied. Patient characteristics were as follows: median age 79 years (range, 76-85 years), clinical stage I/II/III/IV (7/8/8/2, respectively), and surgically resectable/unresectable (17/8, respectively). The completion rates of radiation therapy and chemoradiation therapy were 100% and 84%, respectively. Grade ≥3 acute toxicities included neutropenia (76%), leukopenia (72%), thrombocytopenia (32%), anemia (28%), anorexia (32%), oral mucositis (20%), febrile neutropenia (12%), and esophagitis (8%). Grade ≥3 late toxicities included esophageal stenosis (12%) and pleural effusion (4%). The complete response rate was 64%. In the median follow-up period of 18.9 months, the 1-year overall survival rate was 68%. Conclusions: Definitive chemoradiation therapy with nedaplatin and 5-fluorouracil may be a feasible treatment option for elderly patients with esophageal squamous cell carcinoma.http://www.sciencedirect.com/science/article/pii/S2452109418300356 |
| spellingShingle | Akinori Watanabe, MD Chikatoshi Katada, MD, PhD Shouko Komori, MD Hiromitsu Moriya, MD, PhD Keishi Yamashita, MD, PhD Hiroki Harada, MD Mizutomo Azuma, MD, PhD Yuki Kondo, MD Yo Kubota, MD Yasuaki Furue, MD Natsuko Kawanishi, MD Sakiko Yamane, MD Takuya Wada, MD Takafumi Yano, MD Kenji Ishido, MD, PhD Satoshi Tanabe, MD, PhD Kazushige Hayakawa, MD, PhD Wasaburo Koizumi, MD, PhD Feasibility of definitive chemoradiation therapy with nedaplatin and 5-fluorouracil in elderly patients with esophageal squamous cell carcinoma: A retrospective study Advances in Radiation Oncology |
| title | Feasibility of definitive chemoradiation therapy with nedaplatin and 5-fluorouracil in elderly patients with esophageal squamous cell carcinoma: A retrospective study |
| title_full | Feasibility of definitive chemoradiation therapy with nedaplatin and 5-fluorouracil in elderly patients with esophageal squamous cell carcinoma: A retrospective study |
| title_fullStr | Feasibility of definitive chemoradiation therapy with nedaplatin and 5-fluorouracil in elderly patients with esophageal squamous cell carcinoma: A retrospective study |
| title_full_unstemmed | Feasibility of definitive chemoradiation therapy with nedaplatin and 5-fluorouracil in elderly patients with esophageal squamous cell carcinoma: A retrospective study |
| title_short | Feasibility of definitive chemoradiation therapy with nedaplatin and 5-fluorouracil in elderly patients with esophageal squamous cell carcinoma: A retrospective study |
| title_sort | feasibility of definitive chemoradiation therapy with nedaplatin and 5 fluorouracil in elderly patients with esophageal squamous cell carcinoma a retrospective study |
| url | http://www.sciencedirect.com/science/article/pii/S2452109418300356 |
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