The role of Traditional Chinese medicine in anti-HBV: background, progress, and challenges
Abstract Chronic hepatitis B (CHB) remains a major world's most serious public health issues. Despite the remarkable effect of nucleos(t)ide analogues (NAs) in inhibiting hepatitis B virus (HBV) deoxyribonucleic acid (DNA) as the first-line drug, there are several limitations still, such as poo...
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| Format: | Article |
| Language: | English |
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BMC
2023-12-01
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| Series: | Chinese Medicine |
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| Online Access: | https://doi.org/10.1186/s13020-023-00861-2 |
| _version_ | 1797413972118339584 |
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| author | Feilin Ge Yan Yang Zhaofang Bai Lanlan Si Xuemei Wang Jia Yu Xiaohe Xiao Yan Liu Zhigang Ren |
| author_facet | Feilin Ge Yan Yang Zhaofang Bai Lanlan Si Xuemei Wang Jia Yu Xiaohe Xiao Yan Liu Zhigang Ren |
| author_sort | Feilin Ge |
| collection | DOAJ |
| description | Abstract Chronic hepatitis B (CHB) remains a major world's most serious public health issues. Despite the remarkable effect of nucleos(t)ide analogues (NAs) in inhibiting hepatitis B virus (HBV) deoxyribonucleic acid (DNA) as the first-line drug, there are several limitations still, such as poor antigen inhibition, drug resistance, low-level viremia, restricting patients' functional cure. Due to the constraints of NAs, traditional medicines, such as traditional Chinese medicine (TCM), have become more prevalently used and researched in the clinical treatment of CHB as complementary alternative therapies. As a consequence, the review focuses on the background based on HBV’s life cycle as well as the NAs’ limitations, progress based on direct and indirect pathway of targeting HBV of TCM, and challenges of TCM. We found TCMs play an increasingly important role in anti-HBV. In a direct antiviral way, they regulate HBV infection, replication, assembly, and other aspects of the HBV life cycle. As for indirect way, TCMs can exert anti-HBV effects through targeting the host, including immune regulation, apoptosis, autophagy, oxidative stress, etc. Especially, TCMs have the advantages of strong antigenic inhibition compared to NAs. Specifically, we can combine the benefits of TCMs in strong HBV antigen inhibition with the benefits of NAs in targeted antiviral effects, in order to find a suitable combination of "TCM + NAs" to contribute to Chinese knowledge of the realisation of the “global elimination of HBV by 2030” goal of the World Health Organization. |
| first_indexed | 2024-03-09T05:26:14Z |
| format | Article |
| id | doaj.art-607376a3e4384b2b9e676a920d41e30d |
| institution | Directory Open Access Journal |
| issn | 1749-8546 |
| language | English |
| last_indexed | 2024-03-09T05:26:14Z |
| publishDate | 2023-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Chinese Medicine |
| spelling | doaj.art-607376a3e4384b2b9e676a920d41e30d2023-12-03T12:36:23ZengBMCChinese Medicine1749-85462023-12-0118111110.1186/s13020-023-00861-2The role of Traditional Chinese medicine in anti-HBV: background, progress, and challengesFeilin Ge0Yan Yang1Zhaofang Bai2Lanlan Si3Xuemei Wang4Jia Yu5Xiaohe Xiao6Yan Liu7Zhigang Ren8Department of Chinese Medicine, The First Affiliated Hospital of Zhengzhou UniversityCollege of Traditional Chinese Medicine, Chongqing Medical UniversityThe Fifth Medical Center, Chinese PLA General HospitalThe Fifth Medical Center, Chinese PLA General HospitalDepartment of Infectious Diseases, The First Affiliated Hospital of Zhengzhou UniversityDepartment of Infectious Diseases, The First Affiliated Hospital of Zhengzhou UniversityThe Fifth Medical Center, Chinese PLA General HospitalThe Fifth Medical Center, Chinese PLA General HospitalDepartment of Infectious Diseases, The First Affiliated Hospital of Zhengzhou UniversityAbstract Chronic hepatitis B (CHB) remains a major world's most serious public health issues. Despite the remarkable effect of nucleos(t)ide analogues (NAs) in inhibiting hepatitis B virus (HBV) deoxyribonucleic acid (DNA) as the first-line drug, there are several limitations still, such as poor antigen inhibition, drug resistance, low-level viremia, restricting patients' functional cure. Due to the constraints of NAs, traditional medicines, such as traditional Chinese medicine (TCM), have become more prevalently used and researched in the clinical treatment of CHB as complementary alternative therapies. As a consequence, the review focuses on the background based on HBV’s life cycle as well as the NAs’ limitations, progress based on direct and indirect pathway of targeting HBV of TCM, and challenges of TCM. We found TCMs play an increasingly important role in anti-HBV. In a direct antiviral way, they regulate HBV infection, replication, assembly, and other aspects of the HBV life cycle. As for indirect way, TCMs can exert anti-HBV effects through targeting the host, including immune regulation, apoptosis, autophagy, oxidative stress, etc. Especially, TCMs have the advantages of strong antigenic inhibition compared to NAs. Specifically, we can combine the benefits of TCMs in strong HBV antigen inhibition with the benefits of NAs in targeted antiviral effects, in order to find a suitable combination of "TCM + NAs" to contribute to Chinese knowledge of the realisation of the “global elimination of HBV by 2030” goal of the World Health Organization.https://doi.org/10.1186/s13020-023-00861-2Traditional Chinese medicineHepatitis B virusNucleos(t)ide analoguesFunctional cureAntiviral mechanism |
| spellingShingle | Feilin Ge Yan Yang Zhaofang Bai Lanlan Si Xuemei Wang Jia Yu Xiaohe Xiao Yan Liu Zhigang Ren The role of Traditional Chinese medicine in anti-HBV: background, progress, and challenges Chinese Medicine Traditional Chinese medicine Hepatitis B virus Nucleos(t)ide analogues Functional cure Antiviral mechanism |
| title | The role of Traditional Chinese medicine in anti-HBV: background, progress, and challenges |
| title_full | The role of Traditional Chinese medicine in anti-HBV: background, progress, and challenges |
| title_fullStr | The role of Traditional Chinese medicine in anti-HBV: background, progress, and challenges |
| title_full_unstemmed | The role of Traditional Chinese medicine in anti-HBV: background, progress, and challenges |
| title_short | The role of Traditional Chinese medicine in anti-HBV: background, progress, and challenges |
| title_sort | role of traditional chinese medicine in anti hbv background progress and challenges |
| topic | Traditional Chinese medicine Hepatitis B virus Nucleos(t)ide analogues Functional cure Antiviral mechanism |
| url | https://doi.org/10.1186/s13020-023-00861-2 |
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