Quantification of clesrovimab, an investigational, half-life extended, anti-respiratory syncytial virus protein F human monoclonal antibody in the nasal epithelial lining fluid of healthy adults

Quantification of clesrovimab, an investigational, half-life extended, anti-respiratory syncytial virus protein F human monoclonal antibody in the nasal epithelial lining fluid of healthy adults

Background: Clesrovimab (MK-1654) is an investigational, half-life extended human monoclonal antibody (mAb) against RSV F glycoprotein in clinical trials as a prophylactic agent against RSV infection for infants. Methods: This adult study measured clesrovimab concentrations in the serum and nasal ep...

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Bibliographic Details
Main Authors: Jia Yao Phuah, Brian M. Maas, Aimin Tang, Ying Zhang, Luzelena Caro, Radha A. Railkar, Michael D. Swanson, Yu Cao, Hankun Li, Brad Roadcap, Andrew P. Catchpole, Antonios O. Aliprantis, Kalpit A. Vora
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Respiratory syncytial virus
Monoclonal antibody
RSV
Nasal epithelial lining fluid
Urea normalization
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223016499

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