Cryo-EM reveals the molecular basis oflaminin polymerization and LN-lamininopathies
In this work the authors report the cryo-EM structure of the laminin polymer node and reveal the molecular basis of calcium-dependent formation of laminin lattice. The work provides insights into laminin polymerization defects manifesting in human disease.
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-01-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-36077-z |
| _version_ | 1797945804938280960 |
|---|---|
| author | Arkadiusz W. Kulczyk Karen K. McKee Ximo Zhang Iwona Bizukojc Ying Q. Yu Peter D. Yurchenco |
| author_facet | Arkadiusz W. Kulczyk Karen K. McKee Ximo Zhang Iwona Bizukojc Ying Q. Yu Peter D. Yurchenco |
| author_sort | Arkadiusz W. Kulczyk |
| collection | DOAJ |
| description | In this work the authors report the cryo-EM structure of the laminin polymer node and reveal the molecular basis of calcium-dependent formation of laminin lattice. The work provides insights into laminin polymerization defects manifesting in human disease. |
| first_indexed | 2024-04-10T21:00:55Z |
| format | Article |
| id | doaj.art-60769db0fb56402eb40aadb01cc00d25 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-10T21:00:55Z |
| publishDate | 2023-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-60769db0fb56402eb40aadb01cc00d252023-01-22T12:18:05ZengNature PortfolioNature Communications2041-17232023-01-011411710.1038/s41467-023-36077-zCryo-EM reveals the molecular basis oflaminin polymerization and LN-lamininopathiesArkadiusz W. Kulczyk0Karen K. McKee1Ximo Zhang2Iwona Bizukojc3Ying Q. Yu4Peter D. Yurchenco5Institute for Quantitative Biomedicine, Department of Biochemistry and Microbiology, Rutgers UniversityDepartment of Pathology and Laboratory Medicine, Rutgers University - Robert Wood Johnson Medical SchoolWaters CorporationWaters CorporationWaters CorporationDepartment of Pathology and Laboratory Medicine, Rutgers University - Robert Wood Johnson Medical SchoolIn this work the authors report the cryo-EM structure of the laminin polymer node and reveal the molecular basis of calcium-dependent formation of laminin lattice. The work provides insights into laminin polymerization defects manifesting in human disease.https://doi.org/10.1038/s41467-023-36077-z |
| spellingShingle | Arkadiusz W. Kulczyk Karen K. McKee Ximo Zhang Iwona Bizukojc Ying Q. Yu Peter D. Yurchenco Cryo-EM reveals the molecular basis oflaminin polymerization and LN-lamininopathies Nature Communications |
| title | Cryo-EM reveals the molecular basis oflaminin polymerization and LN-lamininopathies |
| title_full | Cryo-EM reveals the molecular basis oflaminin polymerization and LN-lamininopathies |
| title_fullStr | Cryo-EM reveals the molecular basis oflaminin polymerization and LN-lamininopathies |
| title_full_unstemmed | Cryo-EM reveals the molecular basis oflaminin polymerization and LN-lamininopathies |
| title_short | Cryo-EM reveals the molecular basis oflaminin polymerization and LN-lamininopathies |
| title_sort | cryo em reveals the molecular basis oflaminin polymerization and ln lamininopathies |
| url | https://doi.org/10.1038/s41467-023-36077-z |
| work_keys_str_mv | AT arkadiuszwkulczyk cryoemrevealsthemolecularbasisoflamininpolymerizationandlnlamininopathies AT karenkmckee cryoemrevealsthemolecularbasisoflamininpolymerizationandlnlamininopathies AT ximozhang cryoemrevealsthemolecularbasisoflamininpolymerizationandlnlamininopathies AT iwonabizukojc cryoemrevealsthemolecularbasisoflamininpolymerizationandlnlamininopathies AT yingqyu cryoemrevealsthemolecularbasisoflamininpolymerizationandlnlamininopathies AT peterdyurchenco cryoemrevealsthemolecularbasisoflamininpolymerizationandlnlamininopathies |