The supplementary effects of omega-3 fatty acid alone and in a combination with vitamin D3 on serum leptin levels: A randomized clinical trial on men and women with vitamin D deficiency
Purpose: This randomized clinical trial (RCT) was designed to assess the effect of VD3, n-3FA, and their combination on serum leptin levels in people with vitamin D deficiency (VDD). Subjects and methods: One hundred and forty six participants, were randomly assigned into four group...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Pensoft Publishers
2021-07-01
|
| Series: | Pharmacia |
| Online Access: | https://pharmacia.pensoft.net/article/64422/download/pdf/ |
| _version_ | 1818337348338843648 |
|---|---|
| author | Mahmoud S. Abu-Samak Luai Z. Hasoun Abeer Barham Beisan A. Mohammad Ibrahim Mosleh Ahmad Aljaberi Shady H. Awwad |
| author_facet | Mahmoud S. Abu-Samak Luai Z. Hasoun Abeer Barham Beisan A. Mohammad Ibrahim Mosleh Ahmad Aljaberi Shady H. Awwad |
| author_sort | Mahmoud S. Abu-Samak |
| collection | DOAJ |
| description | Purpose: This randomized clinical trial (RCT) was designed to assess the effect of VD3, n-3FA, and their combination on serum leptin levels in people with vitamin D deficiency (VDD). Subjects and methods: One hundred and forty six participants, were randomly assigned into four groups supplemented with the dose of 50,000 IU VD3 taken weekly (D), 300 mg n-3FA taken daily (Om), and their combination (D+Om) or control (C) for eight weeks. Fasting baseline and follow-up (10 weeks; 8 weeks supplementation plus washout period of 2 weeks) of serum 25 hydroxyvitamin D (25OHD), leptin, glucose, triglycerides (TG), parathyroid hormone (PTH), calcium, and phosphorus were assayed. A paired T-test was used to assess the changes in serum leptin levels over of the follow-up period. Results: Significant increase in follow-up serum leptin (10.62 ± 7.18 to 14.42 ± 8.29 ng/mL, P = 0.002) and TG (154 ± 84.4 to 200.1 ± 79, P = 0.015) levels were observed in n-3-FA supplemented group. Combination therapy (VD3 plus n-3 FA) significantly increased serum 25OHD (13.49 ± 4.64 to 37.09 ± 11.13 ng/mL, P < 0.001), TG levels (114.3 ± 57.3 to 139.1 ± 60.7 mg/mL, P = 0.007) and insignificantly serum leptin (6.74 ± 4.87 to 8.01 ± 6.77 ng/mL, P = 0.269). Conclusion: Our study referred that notable elevation in leptin and TG levels might be linked to leptin resistance. However, further RCTs are required to clarify possible consequences resulted from the extensive administration of n-3FA supplements and their combinations with high doses of VD3 supplements on humans’ health. |
| first_indexed | 2024-12-13T14:53:47Z |
| format | Article |
| id | doaj.art-607755d985e246c8ab312d502682473a |
| institution | Directory Open Access Journal |
| issn | 2603-557X |
| language | English |
| last_indexed | 2024-12-13T14:53:47Z |
| publishDate | 2021-07-01 |
| publisher | Pensoft Publishers |
| record_format | Article |
| series | Pharmacia |
| spelling | doaj.art-607755d985e246c8ab312d502682473a2022-12-21T23:41:17ZengPensoft PublishersPharmacia2603-557X2021-07-0168351752510.3897/pharmacia.68.e6442264422The supplementary effects of omega-3 fatty acid alone and in a combination with vitamin D3 on serum leptin levels: A randomized clinical trial on men and women with vitamin D deficiencyMahmoud S. Abu-Samak0Luai Z. Hasoun1Abeer Barham2Beisan A. Mohammad3Ibrahim Mosleh4Ahmad Aljaberi5Shady H. Awwad6Applied Science Private UniversityApplied Science Private UniversityApplied Science Private UniversityFakeeh College for Medical SciencesJordan UniversityApplied Science Private UniversityApplied Science Private UniversityPurpose: This randomized clinical trial (RCT) was designed to assess the effect of VD3, n-3FA, and their combination on serum leptin levels in people with vitamin D deficiency (VDD). Subjects and methods: One hundred and forty six participants, were randomly assigned into four groups supplemented with the dose of 50,000 IU VD3 taken weekly (D), 300 mg n-3FA taken daily (Om), and their combination (D+Om) or control (C) for eight weeks. Fasting baseline and follow-up (10 weeks; 8 weeks supplementation plus washout period of 2 weeks) of serum 25 hydroxyvitamin D (25OHD), leptin, glucose, triglycerides (TG), parathyroid hormone (PTH), calcium, and phosphorus were assayed. A paired T-test was used to assess the changes in serum leptin levels over of the follow-up period. Results: Significant increase in follow-up serum leptin (10.62 ± 7.18 to 14.42 ± 8.29 ng/mL, P = 0.002) and TG (154 ± 84.4 to 200.1 ± 79, P = 0.015) levels were observed in n-3-FA supplemented group. Combination therapy (VD3 plus n-3 FA) significantly increased serum 25OHD (13.49 ± 4.64 to 37.09 ± 11.13 ng/mL, P < 0.001), TG levels (114.3 ± 57.3 to 139.1 ± 60.7 mg/mL, P = 0.007) and insignificantly serum leptin (6.74 ± 4.87 to 8.01 ± 6.77 ng/mL, P = 0.269). Conclusion: Our study referred that notable elevation in leptin and TG levels might be linked to leptin resistance. However, further RCTs are required to clarify possible consequences resulted from the extensive administration of n-3FA supplements and their combinations with high doses of VD3 supplements on humans’ health.https://pharmacia.pensoft.net/article/64422/download/pdf/ |
| spellingShingle | Mahmoud S. Abu-Samak Luai Z. Hasoun Abeer Barham Beisan A. Mohammad Ibrahim Mosleh Ahmad Aljaberi Shady H. Awwad The supplementary effects of omega-3 fatty acid alone and in a combination with vitamin D3 on serum leptin levels: A randomized clinical trial on men and women with vitamin D deficiency Pharmacia |
| title | The supplementary effects of omega-3 fatty acid alone and in a combination with vitamin D3 on serum leptin levels: A randomized clinical trial on men and women with vitamin D deficiency |
| title_full | The supplementary effects of omega-3 fatty acid alone and in a combination with vitamin D3 on serum leptin levels: A randomized clinical trial on men and women with vitamin D deficiency |
| title_fullStr | The supplementary effects of omega-3 fatty acid alone and in a combination with vitamin D3 on serum leptin levels: A randomized clinical trial on men and women with vitamin D deficiency |
| title_full_unstemmed | The supplementary effects of omega-3 fatty acid alone and in a combination with vitamin D3 on serum leptin levels: A randomized clinical trial on men and women with vitamin D deficiency |
| title_short | The supplementary effects of omega-3 fatty acid alone and in a combination with vitamin D3 on serum leptin levels: A randomized clinical trial on men and women with vitamin D deficiency |
| title_sort | supplementary effects of omega 3 fatty acid alone and in a combination with vitamin d3 on serum leptin levels a randomized clinical trial on men and women with vitamin d deficiency |
| url | https://pharmacia.pensoft.net/article/64422/download/pdf/ |
| work_keys_str_mv | AT mahmoudsabusamak thesupplementaryeffectsofomega3fattyacidaloneandinacombinationwithvitamind3onserumleptinlevelsarandomizedclinicaltrialonmenandwomenwithvitaminddeficiency AT luaizhasoun thesupplementaryeffectsofomega3fattyacidaloneandinacombinationwithvitamind3onserumleptinlevelsarandomizedclinicaltrialonmenandwomenwithvitaminddeficiency AT abeerbarham thesupplementaryeffectsofomega3fattyacidaloneandinacombinationwithvitamind3onserumleptinlevelsarandomizedclinicaltrialonmenandwomenwithvitaminddeficiency AT beisanamohammad thesupplementaryeffectsofomega3fattyacidaloneandinacombinationwithvitamind3onserumleptinlevelsarandomizedclinicaltrialonmenandwomenwithvitaminddeficiency AT ibrahimmosleh thesupplementaryeffectsofomega3fattyacidaloneandinacombinationwithvitamind3onserumleptinlevelsarandomizedclinicaltrialonmenandwomenwithvitaminddeficiency AT ahmadaljaberi thesupplementaryeffectsofomega3fattyacidaloneandinacombinationwithvitamind3onserumleptinlevelsarandomizedclinicaltrialonmenandwomenwithvitaminddeficiency AT shadyhawwad thesupplementaryeffectsofomega3fattyacidaloneandinacombinationwithvitamind3onserumleptinlevelsarandomizedclinicaltrialonmenandwomenwithvitaminddeficiency AT mahmoudsabusamak supplementaryeffectsofomega3fattyacidaloneandinacombinationwithvitamind3onserumleptinlevelsarandomizedclinicaltrialonmenandwomenwithvitaminddeficiency AT luaizhasoun supplementaryeffectsofomega3fattyacidaloneandinacombinationwithvitamind3onserumleptinlevelsarandomizedclinicaltrialonmenandwomenwithvitaminddeficiency AT abeerbarham supplementaryeffectsofomega3fattyacidaloneandinacombinationwithvitamind3onserumleptinlevelsarandomizedclinicaltrialonmenandwomenwithvitaminddeficiency AT beisanamohammad supplementaryeffectsofomega3fattyacidaloneandinacombinationwithvitamind3onserumleptinlevelsarandomizedclinicaltrialonmenandwomenwithvitaminddeficiency AT ibrahimmosleh supplementaryeffectsofomega3fattyacidaloneandinacombinationwithvitamind3onserumleptinlevelsarandomizedclinicaltrialonmenandwomenwithvitaminddeficiency AT ahmadaljaberi supplementaryeffectsofomega3fattyacidaloneandinacombinationwithvitamind3onserumleptinlevelsarandomizedclinicaltrialonmenandwomenwithvitaminddeficiency AT shadyhawwad supplementaryeffectsofomega3fattyacidaloneandinacombinationwithvitamind3onserumleptinlevelsarandomizedclinicaltrialonmenandwomenwithvitaminddeficiency |