Differential Influence of Age on the Relationship between Genetic Mismatch and A(H1N1)pdm09 Vaccine Effectiveness
Assessment of influenza vaccine effectiveness (VE) and identification of relevant influencing factors are the current priorities for optimizing vaccines to reduce the impacts of influenza. To date, how the difference between epidemic strains and vaccine strains at genetic scale affects age-specific...
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MDPI AG
2021-04-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/13/4/619 |
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| author | Lirong Cao Shi Zhao Jingzhi Lou Hong Zheng Renee W. Y. Chan Marc K. C. Chong Zigui Chen Paul K. S. Chan Benny C. Y. Zee Maggie H. Wang |
| author_facet | Lirong Cao Shi Zhao Jingzhi Lou Hong Zheng Renee W. Y. Chan Marc K. C. Chong Zigui Chen Paul K. S. Chan Benny C. Y. Zee Maggie H. Wang |
| author_sort | Lirong Cao |
| collection | DOAJ |
| description | Assessment of influenza vaccine effectiveness (VE) and identification of relevant influencing factors are the current priorities for optimizing vaccines to reduce the impacts of influenza. To date, how the difference between epidemic strains and vaccine strains at genetic scale affects age-specific vaccine performance remains ambiguous. This study investigated the association between genetic mismatch on hemagglutinin and neuraminidase genes and A(H1N1)pdm09 VE in different age groups with a novel computational approach. We found significant linear relationships between VE and genetic mismatch in children, young adults, and middle-aged adults. In the children’s group, each 3-key amino acid mutation was associated with an average of 10% decrease in vaccine effectiveness in a given epidemic season, and genetic mismatch exerted no influence on VE for the elderly group. We demonstrated that present vaccines were most effective for children, while protection for the elderly was reduced and indifferent to vaccine component updates. Modeling such relationships is practical to inform timely evaluation of VE in different groups of populations during mass vaccination and may inform age-specific vaccination regimens. |
| first_indexed | 2024-03-10T12:36:41Z |
| format | Article |
| id | doaj.art-6077ff53841546f4b8f8e198c8bef8b9 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T12:36:41Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-6077ff53841546f4b8f8e198c8bef8b92023-11-21T14:12:50ZengMDPI AGViruses1999-49152021-04-0113461910.3390/v13040619Differential Influence of Age on the Relationship between Genetic Mismatch and A(H1N1)pdm09 Vaccine EffectivenessLirong Cao0Shi Zhao1Jingzhi Lou2Hong Zheng3Renee W. Y. Chan4Marc K. C. Chong5Zigui Chen6Paul K. S. Chan7Benny C. Y. Zee8Maggie H. Wang9JC School of Public Health and Primary Care, Chinese University of Hong Kong, Shatin, N.T., Hong Kong, ChinaJC School of Public Health and Primary Care, Chinese University of Hong Kong, Shatin, N.T., Hong Kong, ChinaJC School of Public Health and Primary Care, Chinese University of Hong Kong, Shatin, N.T., Hong Kong, ChinaJC School of Public Health and Primary Care, Chinese University of Hong Kong, Shatin, N.T., Hong Kong, ChinaHong Kong Hub of Paediatric Excellence, Chinese University of Hong Kong, Shatin, N.T., Hong Kong, ChinaJC School of Public Health and Primary Care, Chinese University of Hong Kong, Shatin, N.T., Hong Kong, ChinaDepartment of Microbiology, Stanley Ho Centre for Emerging Infectious Diseases, Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Shatin, N.T., Hong Kong, ChinaDepartment of Microbiology, Stanley Ho Centre for Emerging Infectious Diseases, Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Shatin, N.T., Hong Kong, ChinaJC School of Public Health and Primary Care, Chinese University of Hong Kong, Shatin, N.T., Hong Kong, ChinaJC School of Public Health and Primary Care, Chinese University of Hong Kong, Shatin, N.T., Hong Kong, ChinaAssessment of influenza vaccine effectiveness (VE) and identification of relevant influencing factors are the current priorities for optimizing vaccines to reduce the impacts of influenza. To date, how the difference between epidemic strains and vaccine strains at genetic scale affects age-specific vaccine performance remains ambiguous. This study investigated the association between genetic mismatch on hemagglutinin and neuraminidase genes and A(H1N1)pdm09 VE in different age groups with a novel computational approach. We found significant linear relationships between VE and genetic mismatch in children, young adults, and middle-aged adults. In the children’s group, each 3-key amino acid mutation was associated with an average of 10% decrease in vaccine effectiveness in a given epidemic season, and genetic mismatch exerted no influence on VE for the elderly group. We demonstrated that present vaccines were most effective for children, while protection for the elderly was reduced and indifferent to vaccine component updates. Modeling such relationships is practical to inform timely evaluation of VE in different groups of populations during mass vaccination and may inform age-specific vaccination regimens.https://www.mdpi.com/1999-4915/13/4/619A(H1N1)pdm09influenza vaccine effectivenessage-related effectsgenetic mismatch |
| spellingShingle | Lirong Cao Shi Zhao Jingzhi Lou Hong Zheng Renee W. Y. Chan Marc K. C. Chong Zigui Chen Paul K. S. Chan Benny C. Y. Zee Maggie H. Wang Differential Influence of Age on the Relationship between Genetic Mismatch and A(H1N1)pdm09 Vaccine Effectiveness Viruses A(H1N1)pdm09 influenza vaccine effectiveness age-related effects genetic mismatch |
| title | Differential Influence of Age on the Relationship between Genetic Mismatch and A(H1N1)pdm09 Vaccine Effectiveness |
| title_full | Differential Influence of Age on the Relationship between Genetic Mismatch and A(H1N1)pdm09 Vaccine Effectiveness |
| title_fullStr | Differential Influence of Age on the Relationship between Genetic Mismatch and A(H1N1)pdm09 Vaccine Effectiveness |
| title_full_unstemmed | Differential Influence of Age on the Relationship between Genetic Mismatch and A(H1N1)pdm09 Vaccine Effectiveness |
| title_short | Differential Influence of Age on the Relationship between Genetic Mismatch and A(H1N1)pdm09 Vaccine Effectiveness |
| title_sort | differential influence of age on the relationship between genetic mismatch and a h1n1 pdm09 vaccine effectiveness |
| topic | A(H1N1)pdm09 influenza vaccine effectiveness age-related effects genetic mismatch |
| url | https://www.mdpi.com/1999-4915/13/4/619 |
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