The Effect of Vitamin D Supplementation on Inflammation and Markers of Vascular Function in Heart Failure Patients
Objectives: Vitamin D deficiency is prevalent in heart failure (HF) and the anti-inflammatory impacts of vitamin D may affect the pathogenesis of HF. Therefore, the present study aimed to investigate the effect of vitamin D supplementation on echocardiographic and biochemical factors in vitamin D-de...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Aras Part Medical International Press
2019-07-01
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| Series: | Crescent Journal of Medical and Biological Sciences |
| Subjects: | |
| Online Access: | http://www.cjmb.org/pdf.php?id=264 |
| _version_ | 1817991065925320704 |
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| author | Fahimeh Hosseinzadeh Nader Jangi Oskouei Saeid Ghavamzadeh |
| author_facet | Fahimeh Hosseinzadeh Nader Jangi Oskouei Saeid Ghavamzadeh |
| author_sort | Fahimeh Hosseinzadeh |
| collection | DOAJ |
| description | Objectives: Vitamin D deficiency is prevalent in heart failure (HF) and the anti-inflammatory impacts of vitamin D may affect the pathogenesis of HF. Therefore, the present study aimed to investigate the effect of vitamin D supplementation on echocardiographic and biochemical factors in vitamin D-deficient HF patients. Materials and Methods: To this end, 39 HF patients with 25(OH)D ≤20 ng/mL participated in the current double-blind, randomized, and placebo-controlled trial, who belonged to class III, New York Heart Association classification. About 50000 IU vitamin D3 (group D+) or placebo (group D- ) were prescribed within 2 months. Then, the ejection fraction (EF%), tumor necrosis factor alpha (TNF-α), B-type natriuretic peptide (BNP), and high sensitive C-reactive protein (hs-CRP) were assessed before and after supplementation. Results: The mean serum level of 25(OH)D increased markedly in D+ group (P<0.001). The mean increase of EF% was 5.3±9.03% (P=0.03) and the decrease of TNF-α (-0.09 pg/mL, P<0.001) and BNP (-3.14 ng/mL, P=0.04) were statistically significant in D+ group after supplementation. In addition, the blood concentration of BNP declined significantly in D+ group compared to placebo while hs-CRP and TNF-α levels failed to differ between the two groups. Conclusions: The results revealed that vitamin D could be effective against inflammation and thus its supplementation may reduce the severity of HF by improving the serum level of BNP and EF%. However, more clinical trials are required to approve the beneficial role of vitamin D in HF patients. |
| first_indexed | 2024-04-14T01:08:06Z |
| format | Article |
| id | doaj.art-607a62813e4e4036a0e5c3384e2bb4f6 |
| institution | Directory Open Access Journal |
| issn | 2148-9696 |
| language | English |
| last_indexed | 2024-04-14T01:08:06Z |
| publishDate | 2019-07-01 |
| publisher | Aras Part Medical International Press |
| record_format | Article |
| series | Crescent Journal of Medical and Biological Sciences |
| spelling | doaj.art-607a62813e4e4036a0e5c3384e2bb4f62022-12-22T02:21:10ZengAras Part Medical International PressCrescent Journal of Medical and Biological Sciences2148-96962019-07-0163285292cjmb-5048The Effect of Vitamin D Supplementation on Inflammation and Markers of Vascular Function in Heart Failure PatientsFahimeh Hosseinzadeh0Nader Jangi Oskouei1Saeid Ghavamzadeh2Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran.Urmia University of Medical Sciences, Urmia, Iran.Department of Nutrition, Food and Beverages Safety Research Center, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.Objectives: Vitamin D deficiency is prevalent in heart failure (HF) and the anti-inflammatory impacts of vitamin D may affect the pathogenesis of HF. Therefore, the present study aimed to investigate the effect of vitamin D supplementation on echocardiographic and biochemical factors in vitamin D-deficient HF patients. Materials and Methods: To this end, 39 HF patients with 25(OH)D ≤20 ng/mL participated in the current double-blind, randomized, and placebo-controlled trial, who belonged to class III, New York Heart Association classification. About 50000 IU vitamin D3 (group D+) or placebo (group D- ) were prescribed within 2 months. Then, the ejection fraction (EF%), tumor necrosis factor alpha (TNF-α), B-type natriuretic peptide (BNP), and high sensitive C-reactive protein (hs-CRP) were assessed before and after supplementation. Results: The mean serum level of 25(OH)D increased markedly in D+ group (P<0.001). The mean increase of EF% was 5.3±9.03% (P=0.03) and the decrease of TNF-α (-0.09 pg/mL, P<0.001) and BNP (-3.14 ng/mL, P=0.04) were statistically significant in D+ group after supplementation. In addition, the blood concentration of BNP declined significantly in D+ group compared to placebo while hs-CRP and TNF-α levels failed to differ between the two groups. Conclusions: The results revealed that vitamin D could be effective against inflammation and thus its supplementation may reduce the severity of HF by improving the serum level of BNP and EF%. However, more clinical trials are required to approve the beneficial role of vitamin D in HF patients.http://www.cjmb.org/pdf.php?id=264vitamin dheart failuretumor necrosis factor-alphanatriuretic peptidebrain |
| spellingShingle | Fahimeh Hosseinzadeh Nader Jangi Oskouei Saeid Ghavamzadeh The Effect of Vitamin D Supplementation on Inflammation and Markers of Vascular Function in Heart Failure Patients Crescent Journal of Medical and Biological Sciences vitamin d heart failure tumor necrosis factor-alpha natriuretic peptide brain |
| title | The Effect of Vitamin D Supplementation on Inflammation and Markers of Vascular Function in Heart Failure Patients |
| title_full | The Effect of Vitamin D Supplementation on Inflammation and Markers of Vascular Function in Heart Failure Patients |
| title_fullStr | The Effect of Vitamin D Supplementation on Inflammation and Markers of Vascular Function in Heart Failure Patients |
| title_full_unstemmed | The Effect of Vitamin D Supplementation on Inflammation and Markers of Vascular Function in Heart Failure Patients |
| title_short | The Effect of Vitamin D Supplementation on Inflammation and Markers of Vascular Function in Heart Failure Patients |
| title_sort | effect of vitamin d supplementation on inflammation and markers of vascular function in heart failure patients |
| topic | vitamin d heart failure tumor necrosis factor-alpha natriuretic peptide brain |
| url | http://www.cjmb.org/pdf.php?id=264 |
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