Preconditioning in an Inflammatory Milieu Augments the Immunotherapeutic Function of Mesenchymal Stromal Cells

Preconditioning in an Inflammatory Milieu Augments the Immunotherapeutic Function of Mesenchymal Stromal Cells

Multipotent mesenchymal stromal cells (MSCs) have emerged as potent therapeutic agents for multiple indications. However, recent evidence indicates that MSC function is compromised in the physiological post-injury milieu. In this study, bone marrow (BM)- and adipose-derived (AD)-MSCs were preconditi...

Full description

Bibliographic Details
Main Authors:	Luis A. Rodriguez, Arezoo Mohammadipoor, Lucero Alvarado, Robin M. Kamucheka, Amber M. Asher, Leopoldo C. Cancio, Ben Antebi
Format:	Article
Language:	English
Published:	MDPI AG 2019-05-01
Series:	Cells
Subjects:	adipose tissue bone marrow mesenchymal stromal cells (MSCs) hypoxia Cytomix immunomodulation anti-inflammatory
Online Access:	https://www.mdpi.com/2073-4409/8/5/462

Similar Items

Short-term physiological hypoxia potentiates the therapeutic function of mesenchymal stem cells
by: Ben Antebi, et al.
Published: (2018-10-01)

The effect of acute respiratory distress syndrome on bone marrow-derived mesenchymal stem cells
by: Ben Antebi, et al.
Published: (2018-09-01)

Mesenchymal Stromal Cells: Potential Option for COVID-19 Treatment
by: Dragan Primorac, et al.
Published: (2021-09-01)

Comparing the immunomodulatory properties of bone marrow, adipose tissue and birth-associated tissue mesenchymal stromal cells
by: Philipp eMattar, et al.
Published: (2015-11-01)

Impact of Mesenchymal Stromal Cells and Their Extracellular Vesicles in a Rat Model of Kidney Rejection
by: Maria Jose Ramirez-Bajo, et al.
Published: (2020-01-01)

Evaluation of Porcine Versus Human Mesenchymal Stromal Cells From Three Distinct Donor Locations for Cytotherapy
by: Riccardo Schweizer, et al.
Published: (2020-05-01)

Metabolism in Human Mesenchymal Stromal Cells: A Missing Link Between hMSC Biomanufacturing and Therapy?
by: Xuegang Yuan, et al.
Published: (2019-05-01)

Mesenchymal Stromal Cell Secretome: Influencing Therapeutic Potential by Cellular Pre-conditioning
by: Joana R. Ferreira, et al.
Published: (2018-12-01)

Mesenchymal stromal cells (MSCs) and their exosome in acute liver failure (ALF): a comprehensive review
by: Samin Shokravi, et al.
Published: (2022-05-01)

The Importance of Mesenchymal Stromal/Stem Cell Therapy for Cancer
by: Asset A. Kaliyev, et al.
Published: (2024-06-01)

Therapeutic potential of mesenchymal stromal/stem cells in critical‐care patients with systemic inflammatory response syndrome
by: Gerardo‐Javier Martí‐Chillón, et al.
Published: (2023-01-01)

Interaction between Macrophages and Human Mesenchymal Stromal Cells Derived from Bone Marrow and Wharton’s Jelly—A Comparative Study
by: Marta Dymowska, et al.
Published: (2021-11-01)

Immunomodulatory and Anti-fibrotic Effects Following the Infusion of Umbilical Cord Mesenchymal Stromal Cells in a Critically Ill Patient With COVID-19 Presenting Lung Fibrosis: A Case Report
by: Kátia Nunes da Silva, et al.
Published: (2021-11-01)

Tissue Harvesting Site Effect on the Canine Adipose Stromal Vascular Fraction Quantity and Quality
by: Hanan Hendawy, et al.
Published: (2021-02-01)

The antifibrotic potential of IMT504: modulation of GLAST + Wnt1 + bone marrow stromal progenitors and hepatic microenvironment
by: Maximiliano Borda, et al.
Published: (2024-09-01)

Extracellular Vehicles of Oxygen-Depleted Mesenchymal Stromal Cells: Route to Off-Shelf Cellular Therapeutics?
by: Dhir Gala, et al.
Published: (2021-08-01)

Age-related changes in human bone marrow mesenchymal stromal cells: morphology, gene expression profile, immunomodulatory activity and miRNA expression
by: Fulvio Massaro, et al.
Published: (2023-12-01)

Regenerative potential of mesenchymal stromal cells in wound healing: unveiling the influence of normoxic and hypoxic environments
by: Mohamad Mahjoor, et al.
Published: (2023-10-01)

Bone Marrow Microenvironment in Light-Chain Amyloidosis: In Vitro Expansion and Characterization of Mesenchymal Stromal Cells
by: Chiara Valsecchi, et al.
Published: (2021-10-01)

Recent advances in pre-conditioned mesenchymal stem/stromal cell (MSCs) therapy in organ failure; a comprehensive review of preclinical studies
by: Mohammad Saeed Kahrizi, et al.
Published: (2023-06-01)

CD146+ Endometrial-Derived Mesenchymal Stem/Stromal Cell Subpopulation Possesses Exosomal Secretomes with Strong Immunomodulatory miRNA Attributes
by: Clarissa Leñero, et al.
Published: (2022-12-01)

Harnessing mechanical cues in the cellular microenvironment for bone regeneration
by: Timothy O. Josephson, et al.
Published: (2023-10-01)

Isoflurane Preconditioning Promotes the Survival and Migration of Bone Marrow Stromal Cells
by: Yu Sun, et al.
Published: (2015-07-01)

Controlled Release of Encapsuled Stromal-Derived Factor 1α Improves Bone Marrow Mesenchymal Stromal Cells Migration
by: Karolina Bajdak-Rusinek, et al.
Published: (2022-12-01)

Impacts of priming on distinct immunosuppressive mechanisms of mesenchymal stromal cells under translationally relevant conditions
by: Nick Herger, et al.
Published: (2024-03-01)

Peripheral blood monocytes as a therapeutic target for marrow stromal cells in stroke patients
by: Nikunj Satani, et al.
Published: (2022-10-01)

Translating MSC Therapy in the Age of Obesity
by: Lauren Boland, et al.
Published: (2022-07-01)

Which stem cells to choose for regenerative medicine application: Bone marrow and adipose tissue stromal stem cells – Similarities and differences
by: Nehad M Alajez, et al.
Published: (2018-01-01)

Enhanced Proliferative and Osteogenic Potential of Periodontal Ligament Stromal Cells
by: Laura Alves, et al.
Published: (2023-05-01)

Fast assay to predict multipotent mesenchymal stromal cell replicative senescence dynamics
by: Katja Kološa, et al.
Published: (2022-03-01)

A long-term anti-inflammation markedly alleviated high-fat diet-induced obesity by repeated administrations of overexpressing IL10 human umbilical cord-derived mesenchymal stromal cells
by: Liudi Wang, et al.
Published: (2022-06-01)

Proteomic Profiling of the Human Fetal Multipotent Mesenchymal Stromal Cells Secretome
by: Arseniy A. Lobov, et al.
Published: (2020-11-01)

Multiple Myeloma Cells Alter Adipogenesis, Increase Senescence-Related and Inflammatory Gene Transcript Expression, and Alter Metabolism in Preadipocytes
by: Heather Fairfield, et al.
Published: (2021-02-01)

In Vitro Cellular and Molecular Interplay between Human Foreskin-Derived Mesenchymal Stromal/Stem Cells and the Th17 Cell Pathway
by: Mehdi Najar, et al.
Published: (2021-10-01)

Mesenchymal Stromal Cell Secretome for the Treatment of Immune-Mediated Inflammatory Diseases: Latest Trends in Isolation, Content Optimization and Delivery Avenues
by: Elena Munoz-Perez, et al.
Published: (2021-10-01)

Mesenchymal Stromal Cells in Osteoarthritis: Evidence for Structural Benefit and Cartilage Repair
by: Yujie Song, et al.
Published: (2022-05-01)

Comparison of mesenchymal stem cell surface markers from bone marrow aspirates and adipose stromal vascular fraction sites
by: Meghan eSullivan, et al.
Published: (2016-01-01)

The Yin and Yang of the Bone Marrow Microenvironment: Pros and Cons of Mesenchymal Stromal Cells in Acute Myeloid Leukemia
by: Marilena Ciciarello, et al.
Published: (2019-10-01)

First-in-man intravenous implantation of stromal vascular fraction in psoriasis: a case study
by: Comella K, et al.
Published: (2018-03-01)

Effects of transplanted GDNF gene modified marrow stromal cells on focal cerebral ischemia in rat
by: Yunliang eWang, et al.
Published: (2011-12-01)