Probiotics Ingestion Does Not Directly Affect Thyroid Hormonal Parameters in Hypothyroid Patients on Levothyroxine Treatment
PurposeThe relationship between probiotics and levothyroxine (LT4) requirement has not yet been investigated. The aim of this study was to assess whether a mixture of highly charged Lactobacilli and Bifidobacteria (VSL#3®) is able to influence LT4 metabolism acting on the gut microbiota.MethodsA pro...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-11-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fendo.2017.00316/full |
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| author | Giorgia Spaggiari Giorgia Spaggiari Giulia Brigante Giulia Brigante Sara De Vincentis Sara De Vincentis Umberto Cattini Laura Roli Maria Cristina De Santis Enrica Baraldi Simonetta Tagliavini Manuela Varani Tommaso Trenti Vincenzo Rochira Vincenzo Rochira Manuela Simoni Manuela Simoni Daniele Santi Daniele Santi |
| author_facet | Giorgia Spaggiari Giorgia Spaggiari Giulia Brigante Giulia Brigante Sara De Vincentis Sara De Vincentis Umberto Cattini Laura Roli Maria Cristina De Santis Enrica Baraldi Simonetta Tagliavini Manuela Varani Tommaso Trenti Vincenzo Rochira Vincenzo Rochira Manuela Simoni Manuela Simoni Daniele Santi Daniele Santi |
| author_sort | Giorgia Spaggiari |
| collection | DOAJ |
| description | PurposeThe relationship between probiotics and levothyroxine (LT4) requirement has not yet been investigated. The aim of this study was to assess whether a mixture of highly charged Lactobacilli and Bifidobacteria (VSL#3®) is able to influence LT4 metabolism acting on the gut microbiota.MethodsA prospective, randomized, single-blind, controlled, investigator-started clinical trial was carried out. Patients with primary hypothyroidism were randomly assigned to the study (VSL#3® + LT4) and the control group (LT4). A 2-month treatment phase was followed by 2 months of follow-up. Clinical examination, blood tests for thyroid function and for peripheral tissue markers of thyroid hormones (PTM) were performed monthly. LT4 dose adjustments were performed when necessary.ResultsThirty-nine patients were enrolled in the study group and 41 in the control group. No difference in thyroid function [thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), and free thyroxine (fT4)] and PTM was found between groups and among visits. FT3/fT4 ratio was directly correlated to TSH at each visit in both groups, with the exception of the first evaluation of probiotics-treated subjects (rho = 0.287, p = 0.076). LT4 daily dose adjustments occurred more frequently in the control than in the study group (p = 0.007), despite no differences in the mean LT4 daily dose. In particular, LT4 doses were increased six times in the control group and decreased four times in the study group.ConclusionVSL#3® does not directly alter thyroid functional compensation. A probiotics-mediated influence on thyroid hormones homeostasis is suggested since probiotics supplementation could be able to prevent serum hormonal fluctuations.ClinicalTrials.gov IDRegistration number NCT03095963. |
| first_indexed | 2024-12-11T14:11:24Z |
| format | Article |
| id | doaj.art-607b7160ff99452db4829e14cea5f83e |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-11T14:11:24Z |
| publishDate | 2017-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-607b7160ff99452db4829e14cea5f83e2022-12-22T01:03:24ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922017-11-01810.3389/fendo.2017.00316308275Probiotics Ingestion Does Not Directly Affect Thyroid Hormonal Parameters in Hypothyroid Patients on Levothyroxine TreatmentGiorgia Spaggiari0Giorgia Spaggiari1Giulia Brigante2Giulia Brigante3Sara De Vincentis4Sara De Vincentis5Umberto Cattini6Laura Roli7Maria Cristina De Santis8Enrica Baraldi9Simonetta Tagliavini10Manuela Varani11Tommaso Trenti12Vincenzo Rochira13Vincenzo Rochira14Manuela Simoni15Manuela Simoni16Daniele Santi17Daniele Santi18Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, ItalyUnit of Endocrinology, Department of Medicine, Endocrinology, Metabolism and Geriatrics, Azienda Ospedaliero Universitaria di Modena, Modena, ItalyUnit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, ItalyUnit of Endocrinology, Department of Medicine, Endocrinology, Metabolism and Geriatrics, Azienda Ospedaliero Universitaria di Modena, Modena, ItalyUnit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, ItalyUnit of Endocrinology, Department of Medicine, Endocrinology, Metabolism and Geriatrics, Azienda Ospedaliero Universitaria di Modena, Modena, ItalyUnit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, ItalyDepartment of Laboratory Medicine and Pathological Anatomy, Azienda USL of Modena, Modena, ItalyDepartment of Laboratory Medicine and Pathological Anatomy, Azienda USL of Modena, Modena, ItalyDepartment of Laboratory Medicine and Pathological Anatomy, Azienda USL of Modena, Modena, ItalyDepartment of Laboratory Medicine and Pathological Anatomy, Azienda USL of Modena, Modena, ItalyDepartment of Laboratory Medicine and Pathological Anatomy, Azienda USL of Modena, Modena, ItalyDepartment of Laboratory Medicine and Pathological Anatomy, Azienda USL of Modena, Modena, ItalyUnit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, ItalyUnit of Endocrinology, Department of Medicine, Endocrinology, Metabolism and Geriatrics, Azienda Ospedaliero Universitaria di Modena, Modena, ItalyUnit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, ItalyUnit of Endocrinology, Department of Medicine, Endocrinology, Metabolism and Geriatrics, Azienda Ospedaliero Universitaria di Modena, Modena, ItalyUnit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, ItalyUnit of Endocrinology, Department of Medicine, Endocrinology, Metabolism and Geriatrics, Azienda Ospedaliero Universitaria di Modena, Modena, ItalyPurposeThe relationship between probiotics and levothyroxine (LT4) requirement has not yet been investigated. The aim of this study was to assess whether a mixture of highly charged Lactobacilli and Bifidobacteria (VSL#3®) is able to influence LT4 metabolism acting on the gut microbiota.MethodsA prospective, randomized, single-blind, controlled, investigator-started clinical trial was carried out. Patients with primary hypothyroidism were randomly assigned to the study (VSL#3® + LT4) and the control group (LT4). A 2-month treatment phase was followed by 2 months of follow-up. Clinical examination, blood tests for thyroid function and for peripheral tissue markers of thyroid hormones (PTM) were performed monthly. LT4 dose adjustments were performed when necessary.ResultsThirty-nine patients were enrolled in the study group and 41 in the control group. No difference in thyroid function [thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), and free thyroxine (fT4)] and PTM was found between groups and among visits. FT3/fT4 ratio was directly correlated to TSH at each visit in both groups, with the exception of the first evaluation of probiotics-treated subjects (rho = 0.287, p = 0.076). LT4 daily dose adjustments occurred more frequently in the control than in the study group (p = 0.007), despite no differences in the mean LT4 daily dose. In particular, LT4 doses were increased six times in the control group and decreased four times in the study group.ConclusionVSL#3® does not directly alter thyroid functional compensation. A probiotics-mediated influence on thyroid hormones homeostasis is suggested since probiotics supplementation could be able to prevent serum hormonal fluctuations.ClinicalTrials.gov IDRegistration number NCT03095963.http://journal.frontiersin.org/article/10.3389/fendo.2017.00316/fulllevothyroxineprobioticsVSL#3®thyroid-stimulating hormonethyroid hormonesgut microbiota |
| spellingShingle | Giorgia Spaggiari Giorgia Spaggiari Giulia Brigante Giulia Brigante Sara De Vincentis Sara De Vincentis Umberto Cattini Laura Roli Maria Cristina De Santis Enrica Baraldi Simonetta Tagliavini Manuela Varani Tommaso Trenti Vincenzo Rochira Vincenzo Rochira Manuela Simoni Manuela Simoni Daniele Santi Daniele Santi Probiotics Ingestion Does Not Directly Affect Thyroid Hormonal Parameters in Hypothyroid Patients on Levothyroxine Treatment Frontiers in Endocrinology levothyroxine probiotics VSL#3® thyroid-stimulating hormone thyroid hormones gut microbiota |
| title | Probiotics Ingestion Does Not Directly Affect Thyroid Hormonal Parameters in Hypothyroid Patients on Levothyroxine Treatment |
| title_full | Probiotics Ingestion Does Not Directly Affect Thyroid Hormonal Parameters in Hypothyroid Patients on Levothyroxine Treatment |
| title_fullStr | Probiotics Ingestion Does Not Directly Affect Thyroid Hormonal Parameters in Hypothyroid Patients on Levothyroxine Treatment |
| title_full_unstemmed | Probiotics Ingestion Does Not Directly Affect Thyroid Hormonal Parameters in Hypothyroid Patients on Levothyroxine Treatment |
| title_short | Probiotics Ingestion Does Not Directly Affect Thyroid Hormonal Parameters in Hypothyroid Patients on Levothyroxine Treatment |
| title_sort | probiotics ingestion does not directly affect thyroid hormonal parameters in hypothyroid patients on levothyroxine treatment |
| topic | levothyroxine probiotics VSL#3® thyroid-stimulating hormone thyroid hormones gut microbiota |
| url | http://journal.frontiersin.org/article/10.3389/fendo.2017.00316/full |
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