Regulatory phosphorylation of Ikaros by Bruton's tyrosine kinase.

Regulatory phosphorylation of Ikaros by Bruton's tyrosine kinase.

Diminished Ikaros function has been implicated in the pathogenesis of acute lymphoblastic leukemia (ALL), the most common form of childhood cancer. Therefore, a stringent regulation of Ikaros is of paramount importance for normal lymphocyte ontogeny. Here we provide genetic and biochemical evidence...

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Bibliographic Details
Main Authors: Hong Ma, Sanjive Qazi, Zahide Ozer, Jian Zhang, Rita Ishkhanian, Fatih M Uckun
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3747153?pdf=render

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