Exploring Acceptability Drivers of Oral Antibiotics in Children: Findings from an International Observational Study
Antibiotics are among the most commonly prescribed drugs in children. Adherence to the treatment with these drugs is of the utmost importance to prevent the emergence of resistant bacteria, a global health threat. In children, medicine acceptability is likely to have a significant impact on complian...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/13/10/1721 |
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| author | Thibault Vallet Yahya Bensouda Jumpei Saito Liv Mathiesen Varsha Pokharkar Viviane Klingmann Matthew Peak Omar Elhamdaoui Akimasa Yamatani Ivana Ivanovic Manjusha Sajith Juliane Münch Louise Bracken Jennifer Claire Duncan Smita Salunke Siri Wang Fabrice Ruiz |
| author_facet | Thibault Vallet Yahya Bensouda Jumpei Saito Liv Mathiesen Varsha Pokharkar Viviane Klingmann Matthew Peak Omar Elhamdaoui Akimasa Yamatani Ivana Ivanovic Manjusha Sajith Juliane Münch Louise Bracken Jennifer Claire Duncan Smita Salunke Siri Wang Fabrice Ruiz |
| author_sort | Thibault Vallet |
| collection | DOAJ |
| description | Antibiotics are among the most commonly prescribed drugs in children. Adherence to the treatment with these drugs is of the utmost importance to prevent the emergence of resistant bacteria, a global health threat. In children, medicine acceptability is likely to have a significant impact on compliance. Herein we used a multivariate approach, considering simultaneously the many aspects of acceptability to explore the drivers of oral antibiotic acceptability in children under twelve, especially in toddlers and in preschoolers. Based on 628 real-life observer reports of the intake of 133 distinct medicines, the acceptability reference framework highlighted the influence of many factors such as age and sex of patients, previous exposure to treatment, place of administration, administration device, flavor agent in excipients and active pharmaceutical ingredient. These findings from an international observational study emphasize the multidimensional nature of acceptability. Therefore, it is crucial to consider all these different aspects for assessing this multi-faceted concept and designing or prescribing a medicine in order to reach adequate acceptability in the target population. |
| first_indexed | 2024-03-10T06:16:13Z |
| format | Article |
| id | doaj.art-607bf96c516f42b69fe4603c77bcf9e3 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T06:16:13Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-607bf96c516f42b69fe4603c77bcf9e32023-11-22T19:40:21ZengMDPI AGPharmaceutics1999-49232021-10-011310172110.3390/pharmaceutics13101721Exploring Acceptability Drivers of Oral Antibiotics in Children: Findings from an International Observational StudyThibault Vallet0Yahya Bensouda1Jumpei Saito2Liv Mathiesen3Varsha Pokharkar4Viviane Klingmann5Matthew Peak6Omar Elhamdaoui7Akimasa Yamatani8Ivana Ivanovic9Manjusha Sajith10Juliane Münch11Louise Bracken12Jennifer Claire Duncan13Smita Salunke14Siri Wang15Fabrice Ruiz16ClinSearch, 92240 Malakoff, FranceFaculty of Pharmacy and Medicine, Mohammed V University in Rabat, Rabat 10170, MoroccoNational Center for Child Health and Development, Tokyo 157-8535, JapanDepartment of Pharmacy, Section for Pharmacology and Pharmaceutical Biosciences, University of Oslo, 0316 Oslo, NorwayPoona College of Pharmacy, Bharati Vidyapeeth Deemed University, Pune 411038, IndiaDepartment of General Paediatrics, Neonatology and Paediatric Cardiology, University Hospital Düsseldorf, 40225 Düsseldorf, GermanyPaediatric Medicines Research Unit, Institute in the Park, Alder Hey Children’s NHS Foundation Trust, Eaton Road, Liverpool L12 2AP, UKFaculty of Pharmacy and Medicine, Mohammed V University in Rabat, Rabat 10170, MoroccoNational Center for Child Health and Development, Tokyo 157-8535, JapanDepartment of Pharmacy, Section for Pharmacology and Pharmaceutical Biosciences, University of Oslo, 0316 Oslo, NorwayPoona College of Pharmacy, Bharati Vidyapeeth Deemed University, Pune 411038, IndiaDepartment of General Paediatrics, Neonatology and Paediatric Cardiology, University Hospital Düsseldorf, 40225 Düsseldorf, GermanyPaediatric Medicines Research Unit, Institute in the Park, Alder Hey Children’s NHS Foundation Trust, Eaton Road, Liverpool L12 2AP, UKPaediatric Medicines Research Unit, Institute in the Park, Alder Hey Children’s NHS Foundation Trust, Eaton Road, Liverpool L12 2AP, UKDepartment of Pharmaceutics, University College London School of Pharmacy, London WC1N 1AX, UKNorwegian Medicines Agency, 0213 Oslo, NorwayClinSearch, 92240 Malakoff, FranceAntibiotics are among the most commonly prescribed drugs in children. Adherence to the treatment with these drugs is of the utmost importance to prevent the emergence of resistant bacteria, a global health threat. In children, medicine acceptability is likely to have a significant impact on compliance. Herein we used a multivariate approach, considering simultaneously the many aspects of acceptability to explore the drivers of oral antibiotic acceptability in children under twelve, especially in toddlers and in preschoolers. Based on 628 real-life observer reports of the intake of 133 distinct medicines, the acceptability reference framework highlighted the influence of many factors such as age and sex of patients, previous exposure to treatment, place of administration, administration device, flavor agent in excipients and active pharmaceutical ingredient. These findings from an international observational study emphasize the multidimensional nature of acceptability. Therefore, it is crucial to consider all these different aspects for assessing this multi-faceted concept and designing or prescribing a medicine in order to reach adequate acceptability in the target population.https://www.mdpi.com/1999-4923/13/10/1721acceptabilityantibioticformulationpediatricchildrenClinSearch acceptability score test (CAST) |
| spellingShingle | Thibault Vallet Yahya Bensouda Jumpei Saito Liv Mathiesen Varsha Pokharkar Viviane Klingmann Matthew Peak Omar Elhamdaoui Akimasa Yamatani Ivana Ivanovic Manjusha Sajith Juliane Münch Louise Bracken Jennifer Claire Duncan Smita Salunke Siri Wang Fabrice Ruiz Exploring Acceptability Drivers of Oral Antibiotics in Children: Findings from an International Observational Study Pharmaceutics acceptability antibiotic formulation pediatric children ClinSearch acceptability score test (CAST) |
| title | Exploring Acceptability Drivers of Oral Antibiotics in Children: Findings from an International Observational Study |
| title_full | Exploring Acceptability Drivers of Oral Antibiotics in Children: Findings from an International Observational Study |
| title_fullStr | Exploring Acceptability Drivers of Oral Antibiotics in Children: Findings from an International Observational Study |
| title_full_unstemmed | Exploring Acceptability Drivers of Oral Antibiotics in Children: Findings from an International Observational Study |
| title_short | Exploring Acceptability Drivers of Oral Antibiotics in Children: Findings from an International Observational Study |
| title_sort | exploring acceptability drivers of oral antibiotics in children findings from an international observational study |
| topic | acceptability antibiotic formulation pediatric children ClinSearch acceptability score test (CAST) |
| url | https://www.mdpi.com/1999-4923/13/10/1721 |
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