Second- and Third-Tier Therapies for Severe Traumatic Brain Injury
Intracranial hypertension is a common finding in patients with severe traumatic brain injury. These patients need treatment in the intensive care unit, where intracranial pressure monitoring and, whenever possible, multimodal neuromonitoring can be applied. A three-tier approach is suggested in curr...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/11/16/4790 |
| _version_ | 1797432093433659392 |
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| author | Charikleia S. Vrettou Spyros D. Mentzelopoulos |
| author_facet | Charikleia S. Vrettou Spyros D. Mentzelopoulos |
| author_sort | Charikleia S. Vrettou |
| collection | DOAJ |
| description | Intracranial hypertension is a common finding in patients with severe traumatic brain injury. These patients need treatment in the intensive care unit, where intracranial pressure monitoring and, whenever possible, multimodal neuromonitoring can be applied. A three-tier approach is suggested in current recommendations, in which higher-tier therapies have more significant side effects. In this review, we explain the rationale for this approach, and analyze the benefits and risks of each therapeutic modality. Finally, we discuss, based on the most recent recommendations, how this approach can be adapted in low- and middle-income countries, where available resources are limited. |
| first_indexed | 2024-03-09T09:55:19Z |
| format | Article |
| id | doaj.art-607cfa0f6cce48a89958f037c95c0618 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T09:55:19Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-607cfa0f6cce48a89958f037c95c06182023-12-01T23:50:34ZengMDPI AGJournal of Clinical Medicine2077-03832022-08-011116479010.3390/jcm11164790Second- and Third-Tier Therapies for Severe Traumatic Brain InjuryCharikleia S. Vrettou0Spyros D. Mentzelopoulos1First Department of Intensive Care Medicine, Evaggelismos General Hospital, National and Kapodistrian University of Athens Medical School, 10676 Athens, GreeceFirst Department of Intensive Care Medicine, Evaggelismos General Hospital, National and Kapodistrian University of Athens Medical School, 10676 Athens, GreeceIntracranial hypertension is a common finding in patients with severe traumatic brain injury. These patients need treatment in the intensive care unit, where intracranial pressure monitoring and, whenever possible, multimodal neuromonitoring can be applied. A three-tier approach is suggested in current recommendations, in which higher-tier therapies have more significant side effects. In this review, we explain the rationale for this approach, and analyze the benefits and risks of each therapeutic modality. Finally, we discuss, based on the most recent recommendations, how this approach can be adapted in low- and middle-income countries, where available resources are limited.https://www.mdpi.com/2077-0383/11/16/4790brain traumaintracranial hypertensionneuromonitoring |
| spellingShingle | Charikleia S. Vrettou Spyros D. Mentzelopoulos Second- and Third-Tier Therapies for Severe Traumatic Brain Injury Journal of Clinical Medicine brain trauma intracranial hypertension neuromonitoring |
| title | Second- and Third-Tier Therapies for Severe Traumatic Brain Injury |
| title_full | Second- and Third-Tier Therapies for Severe Traumatic Brain Injury |
| title_fullStr | Second- and Third-Tier Therapies for Severe Traumatic Brain Injury |
| title_full_unstemmed | Second- and Third-Tier Therapies for Severe Traumatic Brain Injury |
| title_short | Second- and Third-Tier Therapies for Severe Traumatic Brain Injury |
| title_sort | second and third tier therapies for severe traumatic brain injury |
| topic | brain trauma intracranial hypertension neuromonitoring |
| url | https://www.mdpi.com/2077-0383/11/16/4790 |
| work_keys_str_mv | AT charikleiasvrettou secondandthirdtiertherapiesforseveretraumaticbraininjury AT spyrosdmentzelopoulos secondandthirdtiertherapiesforseveretraumaticbraininjury |