Prognostic nomogram for overall survival in upper urinary tract urothelial carcinoma (UTUC) patients treated with chemotherapy: a SEER-based retrospective cohort study
Abstract Objective To establish a prognostic nomogram among UTUC patients who received chemotherapy. Methods 1195 UTUC patients who received chemotherapy were extracted from the Surveillance, Epidemiology, and End Results (SEER) database for the period between 2004 and 2015. Patients were randomly d...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-01-01
|
| Series: | BMC Urology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12894-022-01172-8 |
| _version_ | 1797795451635761152 |
|---|---|
| author | Cong Tian Jun Liu Lizhe An Yang Hong Qingquan Xu |
| author_facet | Cong Tian Jun Liu Lizhe An Yang Hong Qingquan Xu |
| author_sort | Cong Tian |
| collection | DOAJ |
| description | Abstract Objective To establish a prognostic nomogram among UTUC patients who received chemotherapy. Methods 1195 UTUC patients who received chemotherapy were extracted from the Surveillance, Epidemiology, and End Results (SEER) database for the period between 2004 and 2015. Patients were randomly divided into a training and a validation set. Nomogram was constructed to predict 1-, 3-, and 5-year overall survival (OS) in those patients. Receiver-operating characteristic curves (ROCs), calibration plots, and Decision curve analysis (DCA) were applied to assess and compare the discrimination, accuracy, and practicability of the nomogram with 8th American Joint Committee on Cancer (AJCC) tumor node metastasis (TNM) staging system. Results Six clinical parameters were identified as independent prognostic factors for UTUC patients’ OS, including age, marital status, TNM stage, and surgical methods of the primary site. The ROC curves showed a satisfactory discrimination capacity of the nomogram, with 1-, 3-, and 5-year area under curve (AUC) values of 0.789, 0.772, and 0.763 in the training set and 0.772, 0.822, and 0.814 in the validation set, respectively. Calibration curves indicated a good agreement between actual observation and nomogram prediction. ROC and DCA curves showed our nomograms exhibited larger benefits than the 8th AJCC-TNM staging system. Conclusions A prognostic nomogram was established and validated to present individual predictions of OS among chemotherapeutic UTUC patients. This nomogram may assist clinicians in accurate survival prognostication, treatment decision-making, and design of future clinical trials. |
| first_indexed | 2024-03-13T03:18:08Z |
| format | Article |
| id | doaj.art-607e3c42a6384beebc4ce3ad61e59dbf |
| institution | Directory Open Access Journal |
| issn | 1471-2490 |
| language | English |
| last_indexed | 2024-03-13T03:18:08Z |
| publishDate | 2023-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Urology |
| spelling | doaj.art-607e3c42a6384beebc4ce3ad61e59dbf2023-06-25T11:30:25ZengBMCBMC Urology1471-24902023-01-0123111210.1186/s12894-022-01172-8Prognostic nomogram for overall survival in upper urinary tract urothelial carcinoma (UTUC) patients treated with chemotherapy: a SEER-based retrospective cohort studyCong Tian0Jun Liu1Lizhe An2Yang Hong3Qingquan Xu4Department of Urology, Peking University People’s HospitalDepartment of Urology, Peking University People’s HospitalDepartment of Urology, Peking University People’s HospitalDepartment of Urology, Peking University People’s HospitalDepartment of Urology, Peking University People’s HospitalAbstract Objective To establish a prognostic nomogram among UTUC patients who received chemotherapy. Methods 1195 UTUC patients who received chemotherapy were extracted from the Surveillance, Epidemiology, and End Results (SEER) database for the period between 2004 and 2015. Patients were randomly divided into a training and a validation set. Nomogram was constructed to predict 1-, 3-, and 5-year overall survival (OS) in those patients. Receiver-operating characteristic curves (ROCs), calibration plots, and Decision curve analysis (DCA) were applied to assess and compare the discrimination, accuracy, and practicability of the nomogram with 8th American Joint Committee on Cancer (AJCC) tumor node metastasis (TNM) staging system. Results Six clinical parameters were identified as independent prognostic factors for UTUC patients’ OS, including age, marital status, TNM stage, and surgical methods of the primary site. The ROC curves showed a satisfactory discrimination capacity of the nomogram, with 1-, 3-, and 5-year area under curve (AUC) values of 0.789, 0.772, and 0.763 in the training set and 0.772, 0.822, and 0.814 in the validation set, respectively. Calibration curves indicated a good agreement between actual observation and nomogram prediction. ROC and DCA curves showed our nomograms exhibited larger benefits than the 8th AJCC-TNM staging system. Conclusions A prognostic nomogram was established and validated to present individual predictions of OS among chemotherapeutic UTUC patients. This nomogram may assist clinicians in accurate survival prognostication, treatment decision-making, and design of future clinical trials.https://doi.org/10.1186/s12894-022-01172-8SEERNomogramPrognosisUpper urinary tract urothelial carcinomaChemotherapy |
| spellingShingle | Cong Tian Jun Liu Lizhe An Yang Hong Qingquan Xu Prognostic nomogram for overall survival in upper urinary tract urothelial carcinoma (UTUC) patients treated with chemotherapy: a SEER-based retrospective cohort study BMC Urology SEER Nomogram Prognosis Upper urinary tract urothelial carcinoma Chemotherapy |
| title | Prognostic nomogram for overall survival in upper urinary tract urothelial carcinoma (UTUC) patients treated with chemotherapy: a SEER-based retrospective cohort study |
| title_full | Prognostic nomogram for overall survival in upper urinary tract urothelial carcinoma (UTUC) patients treated with chemotherapy: a SEER-based retrospective cohort study |
| title_fullStr | Prognostic nomogram for overall survival in upper urinary tract urothelial carcinoma (UTUC) patients treated with chemotherapy: a SEER-based retrospective cohort study |
| title_full_unstemmed | Prognostic nomogram for overall survival in upper urinary tract urothelial carcinoma (UTUC) patients treated with chemotherapy: a SEER-based retrospective cohort study |
| title_short | Prognostic nomogram for overall survival in upper urinary tract urothelial carcinoma (UTUC) patients treated with chemotherapy: a SEER-based retrospective cohort study |
| title_sort | prognostic nomogram for overall survival in upper urinary tract urothelial carcinoma utuc patients treated with chemotherapy a seer based retrospective cohort study |
| topic | SEER Nomogram Prognosis Upper urinary tract urothelial carcinoma Chemotherapy |
| url | https://doi.org/10.1186/s12894-022-01172-8 |
| work_keys_str_mv | AT congtian prognosticnomogramforoverallsurvivalinupperurinarytracturothelialcarcinomautucpatientstreatedwithchemotherapyaseerbasedretrospectivecohortstudy AT junliu prognosticnomogramforoverallsurvivalinupperurinarytracturothelialcarcinomautucpatientstreatedwithchemotherapyaseerbasedretrospectivecohortstudy AT lizhean prognosticnomogramforoverallsurvivalinupperurinarytracturothelialcarcinomautucpatientstreatedwithchemotherapyaseerbasedretrospectivecohortstudy AT yanghong prognosticnomogramforoverallsurvivalinupperurinarytracturothelialcarcinomautucpatientstreatedwithchemotherapyaseerbasedretrospectivecohortstudy AT qingquanxu prognosticnomogramforoverallsurvivalinupperurinarytracturothelialcarcinomautucpatientstreatedwithchemotherapyaseerbasedretrospectivecohortstudy |