Mitochonic acid 5 activates the MAPK–ERK–yap signaling pathways to protect mouse microglial BV-2 cells against TNFα-induced apoptosis via increased Bnip3-related mitophagy

Mitochonic acid 5 activates the MAPK–ERK–yap signaling pathways to protect mouse microglial BV-2 cells against TNFα-induced apoptosis via increased Bnip3-related mitophagy

Abstract Background The regulation of microglial function via mitochondrial homeostasis is important in the development of neuroinflammation. The underlying mechanism for this regulatory function remains unclear. In this study, we investigated the protective role of mitochonic acid 5 (MA-5) in micro...

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Bibliographic Details
Main Authors: Qingyun Lei, Jian Tan, Shangqing Yi, Na Wu, Yilin Wang, Heng Wu
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Cellular & Molecular Biology Letters
Subjects:
MA-5
Inflammatory injury
Mitophagy
Microglia
Mitochondria
MAPK–ERK–yap signaling pathway
Online Access:http://link.springer.com/article/10.1186/s11658-018-0081-5

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