Genetic inactivation of SARM1 axon degeneration pathway improves outcome trajectory after experimental traumatic brain injury based on pathological, radiological, and functional measures

Genetic inactivation of SARM1 axon degeneration pathway improves outcome trajectory after experimental traumatic brain injury based on pathological, radiological, and functional measures

Abstract Traumatic brain injury (TBI) causes chronic symptoms and increased risk of neurodegeneration. Axons in white matter tracts, such as the corpus callosum (CC), are critical components of neural circuits and particularly vulnerable to TBI. Treatments are needed to protect axons from traumatic...

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Bibliographic Details
Main Authors: Donald V. Bradshaw, Andrew K. Knutsen, Alexandru Korotcov, Genevieve M. Sullivan, Kryslaine L. Radomski, Bernard J. Dardzinski, Xiaomei Zi, Dennis P. McDaniel, Regina C. Armstrong
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Acta Neuropathologica Communications
Subjects:
Chronic traumatic brain injury
SARM1
Sterile alpha and Toll
interleukin-1 receptor containing motif 1
White matter
Corpus callosum atrophy
Online Access:https://doi.org/10.1186/s40478-021-01193-8

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