Modes of transmission and attack rates of group A Streptococcal infection: a protocol for a systematic review and meta-analysis
Abstract Background Group A Streptococcus (Strep A) is an important cause of mortality and morbidity globally. This bacterium is responsible for a range of different infections and post-infectious sequelae. Summarising the current knowledge of Strep A transmission to humans will address gaps in the...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-03-01
|
| Series: | Systematic Reviews |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13643-021-01641-5 |
| _version_ | 1818641484457443328 |
|---|---|
| author | Dylan D. Barth Jessica Daw Ruomei Xu Stephanie Enkel Janessa Pickering Tracy McRae Mark E. Engel Jonathan Carapetis Rosemary Wyber Asha C. Bowen |
| author_facet | Dylan D. Barth Jessica Daw Ruomei Xu Stephanie Enkel Janessa Pickering Tracy McRae Mark E. Engel Jonathan Carapetis Rosemary Wyber Asha C. Bowen |
| author_sort | Dylan D. Barth |
| collection | DOAJ |
| description | Abstract Background Group A Streptococcus (Strep A) is an important cause of mortality and morbidity globally. This bacterium is responsible for a range of different infections and post-infectious sequelae. Summarising the current knowledge of Strep A transmission to humans will address gaps in the evidence and inform prevention and control strategies. The objective of this study is to evaluate the modes of transmission and attack rates of group A streptococcal infection in human populations. Methods This systematic review protocol was prepared according to the Preferred Reporting Items for Systematic reviews and Meta-analysis Protocols (PRISMA-P) 2015 Statement. Using a comprehensive search strategy to identify any transmission studies that have been published in English since 1980, full-text articles will be identified and considered for inclusion against predefined criteria. We will include all studies reporting on Strep A transmission, who have identified a mode of transmission, and who reported attack rates. Risk of bias will be appraised using an appropriate tool. Our results will be described narratively and where feasible and appropriate, a meta-analysis utilizing the random-effects model will be used to aggregate the incidence proportions (attack rates) for each mode of transmission. In addition, we will also evaluate the emm genotype variants of the M protein causing Strep A infection and the association with transmission routes and attack rates, if any, by setting, socioeconomic background and geographical regions. Discussion We anticipate that this review will contribute to elucidating Strep A modes of transmission which in turn, will serve to inform evidence-based strategies including environmental health activities to reduce the transmission of Strep A in populations at risk of severe disease. Trial registration Systematic review registration: PROSPERO ( CRD42019138472 ). |
| first_indexed | 2024-12-16T23:27:54Z |
| format | Article |
| id | doaj.art-6080acebbbfe4c5582c06fa7e02a79e4 |
| institution | Directory Open Access Journal |
| issn | 2046-4053 |
| language | English |
| last_indexed | 2024-12-16T23:27:54Z |
| publishDate | 2021-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Systematic Reviews |
| spelling | doaj.art-6080acebbbfe4c5582c06fa7e02a79e42022-12-21T22:11:57ZengBMCSystematic Reviews2046-40532021-03-011011710.1186/s13643-021-01641-5Modes of transmission and attack rates of group A Streptococcal infection: a protocol for a systematic review and meta-analysisDylan D. Barth0Jessica Daw1Ruomei Xu2Stephanie Enkel3Janessa Pickering4Tracy McRae5Mark E. Engel6Jonathan Carapetis7Rosemary Wyber8Asha C. Bowen9Wesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids InstituteWesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids InstituteWesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids InstituteWesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids InstituteWesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids InstituteWesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids InstituteAFROStrep Registry, Department of Medicine, The University of Cape TownWesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids InstituteWesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids InstituteWesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids InstituteAbstract Background Group A Streptococcus (Strep A) is an important cause of mortality and morbidity globally. This bacterium is responsible for a range of different infections and post-infectious sequelae. Summarising the current knowledge of Strep A transmission to humans will address gaps in the evidence and inform prevention and control strategies. The objective of this study is to evaluate the modes of transmission and attack rates of group A streptococcal infection in human populations. Methods This systematic review protocol was prepared according to the Preferred Reporting Items for Systematic reviews and Meta-analysis Protocols (PRISMA-P) 2015 Statement. Using a comprehensive search strategy to identify any transmission studies that have been published in English since 1980, full-text articles will be identified and considered for inclusion against predefined criteria. We will include all studies reporting on Strep A transmission, who have identified a mode of transmission, and who reported attack rates. Risk of bias will be appraised using an appropriate tool. Our results will be described narratively and where feasible and appropriate, a meta-analysis utilizing the random-effects model will be used to aggregate the incidence proportions (attack rates) for each mode of transmission. In addition, we will also evaluate the emm genotype variants of the M protein causing Strep A infection and the association with transmission routes and attack rates, if any, by setting, socioeconomic background and geographical regions. Discussion We anticipate that this review will contribute to elucidating Strep A modes of transmission which in turn, will serve to inform evidence-based strategies including environmental health activities to reduce the transmission of Strep A in populations at risk of severe disease. Trial registration Systematic review registration: PROSPERO ( CRD42019138472 ).https://doi.org/10.1186/s13643-021-01641-5Group A StreptococcusTransmissionSystematic reviewEnvironmental healthPublic health |
| spellingShingle | Dylan D. Barth Jessica Daw Ruomei Xu Stephanie Enkel Janessa Pickering Tracy McRae Mark E. Engel Jonathan Carapetis Rosemary Wyber Asha C. Bowen Modes of transmission and attack rates of group A Streptococcal infection: a protocol for a systematic review and meta-analysis Systematic Reviews Group A Streptococcus Transmission Systematic review Environmental health Public health |
| title | Modes of transmission and attack rates of group A Streptococcal infection: a protocol for a systematic review and meta-analysis |
| title_full | Modes of transmission and attack rates of group A Streptococcal infection: a protocol for a systematic review and meta-analysis |
| title_fullStr | Modes of transmission and attack rates of group A Streptococcal infection: a protocol for a systematic review and meta-analysis |
| title_full_unstemmed | Modes of transmission and attack rates of group A Streptococcal infection: a protocol for a systematic review and meta-analysis |
| title_short | Modes of transmission and attack rates of group A Streptococcal infection: a protocol for a systematic review and meta-analysis |
| title_sort | modes of transmission and attack rates of group a streptococcal infection a protocol for a systematic review and meta analysis |
| topic | Group A Streptococcus Transmission Systematic review Environmental health Public health |
| url | https://doi.org/10.1186/s13643-021-01641-5 |
| work_keys_str_mv | AT dylandbarth modesoftransmissionandattackratesofgroupastreptococcalinfectionaprotocolforasystematicreviewandmetaanalysis AT jessicadaw modesoftransmissionandattackratesofgroupastreptococcalinfectionaprotocolforasystematicreviewandmetaanalysis AT ruomeixu modesoftransmissionandattackratesofgroupastreptococcalinfectionaprotocolforasystematicreviewandmetaanalysis AT stephanieenkel modesoftransmissionandattackratesofgroupastreptococcalinfectionaprotocolforasystematicreviewandmetaanalysis AT janessapickering modesoftransmissionandattackratesofgroupastreptococcalinfectionaprotocolforasystematicreviewandmetaanalysis AT tracymcrae modesoftransmissionandattackratesofgroupastreptococcalinfectionaprotocolforasystematicreviewandmetaanalysis AT markeengel modesoftransmissionandattackratesofgroupastreptococcalinfectionaprotocolforasystematicreviewandmetaanalysis AT jonathancarapetis modesoftransmissionandattackratesofgroupastreptococcalinfectionaprotocolforasystematicreviewandmetaanalysis AT rosemarywyber modesoftransmissionandattackratesofgroupastreptococcalinfectionaprotocolforasystematicreviewandmetaanalysis AT ashacbowen modesoftransmissionandattackratesofgroupastreptococcalinfectionaprotocolforasystematicreviewandmetaanalysis |