A theoretical model of the evolution of virulence in sexually transmitted HIV/AIDS
INTRODUCTION: The evolution of virulence in host-parasite relationships has been the subject of several publications. In the case of HIV virulence, some authors suggest that the evolution of HIV virulence correlates with the rate of acquisition of new sexual partners. In contrast some other authors...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Universidade de São Paulo
1999-01-01
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| Series: | Revista de Saúde Pública |
| Subjects: | |
| Online Access: | http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0034-89101999000400002 |
| _version_ | 1818062304836583424 |
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| author | Coutinho FAB Massad E Menezes RX Burattini MN |
| author_facet | Coutinho FAB Massad E Menezes RX Burattini MN |
| author_sort | Coutinho FAB |
| collection | DOAJ |
| description | INTRODUCTION: The evolution of virulence in host-parasite relationships has been the subject of several publications. In the case of HIV virulence, some authors suggest that the evolution of HIV virulence correlates with the rate of acquisition of new sexual partners. In contrast some other authors argue that the level of HIV virulence is independent of the sexual activity of the host population. METHODS: Provide a mathematical model for the study of the potential influence of human sexual behaviour on the evolution of virulence of HIV is provided. RESULTS: The results indicated that, when the probability of acquisition of infection is a function both of the sexual activity and of the virulence level of HIV strains, the evolution of HIV virulence correlates positively with the rate of acquisition of new sexual partners. CONCLUSION: It is concluded that in the case of a host population with a low (high) rate of exchange of sexual partners the evolution of HIV virulence is such that the less (more) virulent strain prevails. |
| first_indexed | 2024-12-10T14:02:05Z |
| format | Article |
| id | doaj.art-6080efd487bf42098a0e52a78e8b3f31 |
| institution | Directory Open Access Journal |
| issn | 0034-8910 1518-8787 |
| language | English |
| last_indexed | 2024-12-10T14:02:05Z |
| publishDate | 1999-01-01 |
| publisher | Universidade de São Paulo |
| record_format | Article |
| series | Revista de Saúde Pública |
| spelling | doaj.art-6080efd487bf42098a0e52a78e8b3f312022-12-22T01:45:47ZengUniversidade de São PauloRevista de Saúde Pública0034-89101518-87871999-01-01334329333A theoretical model of the evolution of virulence in sexually transmitted HIV/AIDSCoutinho FABMassad EMenezes RXBurattini MNINTRODUCTION: The evolution of virulence in host-parasite relationships has been the subject of several publications. In the case of HIV virulence, some authors suggest that the evolution of HIV virulence correlates with the rate of acquisition of new sexual partners. In contrast some other authors argue that the level of HIV virulence is independent of the sexual activity of the host population. METHODS: Provide a mathematical model for the study of the potential influence of human sexual behaviour on the evolution of virulence of HIV is provided. RESULTS: The results indicated that, when the probability of acquisition of infection is a function both of the sexual activity and of the virulence level of HIV strains, the evolution of HIV virulence correlates positively with the rate of acquisition of new sexual partners. CONCLUSION: It is concluded that in the case of a host population with a low (high) rate of exchange of sexual partners the evolution of HIV virulence is such that the less (more) virulent strain prevails.http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0034-89101999000400002Acquired Inmunodeficiency SyndromeVirulenceModels, statistical |
| spellingShingle | Coutinho FAB Massad E Menezes RX Burattini MN A theoretical model of the evolution of virulence in sexually transmitted HIV/AIDS Revista de Saúde Pública Acquired Inmunodeficiency Syndrome Virulence Models, statistical |
| title | A theoretical model of the evolution of virulence in sexually transmitted HIV/AIDS |
| title_full | A theoretical model of the evolution of virulence in sexually transmitted HIV/AIDS |
| title_fullStr | A theoretical model of the evolution of virulence in sexually transmitted HIV/AIDS |
| title_full_unstemmed | A theoretical model of the evolution of virulence in sexually transmitted HIV/AIDS |
| title_short | A theoretical model of the evolution of virulence in sexually transmitted HIV/AIDS |
| title_sort | theoretical model of the evolution of virulence in sexually transmitted hiv aids |
| topic | Acquired Inmunodeficiency Syndrome Virulence Models, statistical |
| url | http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0034-89101999000400002 |
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