COVID-19 and its continuing burden after 12 months: a longitudinal observational prospective multicentre trial
Background Recovery trajectories from coronavirus disease 2019 (COVID-19) call for longitudinal investigation. We aimed to characterise the kinetics and status of clinical, cardiopulmonary and mental health recovery up to 1 year following COVID-19. Methods Clinical evaluation, lung function testing...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
European Respiratory Society
2023-03-01
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| Series: | ERJ Open Research |
| Online Access: | http://openres.ersjournals.com/content/9/2/00317-2022.full |
| _version_ | 1797809364886618112 |
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| author | Sabina Sahanic Piotr Tymoszuk Anna K. Luger Katharina Hüfner Anna Boehm Alex Pizzini Christoph Schwabl Sabine Koppelstätter Katharina Kurz Malte Asshoff Birgit Mosheimer-Feistritzer Maximilian Coen Bernhard Pfeifer Verena Rass Alexander Egger Gregor Hörmann Barbara Sperner-Unterweger Raimund Helbok Ewald Wöll Günter Weiss Gerlig Widmann Ivan Tancevski Thomas Sonnweber Judith Löffler-Ragg |
| author_facet | Sabina Sahanic Piotr Tymoszuk Anna K. Luger Katharina Hüfner Anna Boehm Alex Pizzini Christoph Schwabl Sabine Koppelstätter Katharina Kurz Malte Asshoff Birgit Mosheimer-Feistritzer Maximilian Coen Bernhard Pfeifer Verena Rass Alexander Egger Gregor Hörmann Barbara Sperner-Unterweger Raimund Helbok Ewald Wöll Günter Weiss Gerlig Widmann Ivan Tancevski Thomas Sonnweber Judith Löffler-Ragg |
| author_sort | Sabina Sahanic |
| collection | DOAJ |
| description | Background
Recovery trajectories from coronavirus disease 2019 (COVID-19) call for longitudinal investigation. We aimed to characterise the kinetics and status of clinical, cardiopulmonary and mental health recovery up to 1 year following COVID-19.
Methods
Clinical evaluation, lung function testing (LFT), chest computed tomography (CT) and transthoracic echocardiography were conducted at 2, 3, 6 and 12 months after disease onset. Submaximal exercise capacity, mental health status and quality of life were assessed at 12 months. Recovery kinetics and patterns were investigated by mixed-effect logistic modelling, correlation and clustering analyses. Risk of persistent symptoms and cardiopulmonary abnormalities at the 1-year follow-up were modelled by logistic regression.
Findings
Out of 145 CovILD study participants, 108 (74.5%) completed the 1-year follow-up (median age 56.5 years; 59.3% male; 24% intensive care unit patients). Comorbidities were present in 75% (n=81). Key outcome measures plateaued after 180 days. At 12 months, persistent symptoms were found in 65% of participants; 33% suffered from LFT impairment; 51% showed CT abnormalities; and 63% had low-grade diastolic dysfunction. Main risk factors for cardiopulmonary impairment included pro-inflammatory and immunological biomarkers at early visits. In addition, we deciphered three recovery clusters separating almost complete recovery from patients with post-acute inflammatory profile and an enrichment in cardiopulmonary residuals from a female-dominated post-COVID-19 syndrome with reduced mental health status.
Conclusion
1 year after COVID-19, the burden of persistent symptoms, impaired lung function, radiological abnormalities remains high in our study population. Yet, three recovery trajectories are emerging, ranging from almost complete recovery to post-COVID-19 syndrome with impaired mental health. |
| first_indexed | 2024-03-13T06:52:40Z |
| format | Article |
| id | doaj.art-60825fa00da34e1787780e6842601957 |
| institution | Directory Open Access Journal |
| issn | 2312-0541 |
| language | English |
| last_indexed | 2024-03-13T06:52:40Z |
| publishDate | 2023-03-01 |
| publisher | European Respiratory Society |
| record_format | Article |
| series | ERJ Open Research |
| spelling | doaj.art-60825fa00da34e1787780e68426019572023-06-07T13:31:07ZengEuropean Respiratory SocietyERJ Open Research2312-05412023-03-019210.1183/23120541.00317-202200317-2022COVID-19 and its continuing burden after 12 months: a longitudinal observational prospective multicentre trialSabina Sahanic0Piotr Tymoszuk1Anna K. Luger2Katharina Hüfner3Anna Boehm4Alex Pizzini5Christoph Schwabl6Sabine Koppelstätter7Katharina Kurz8Malte Asshoff9Birgit Mosheimer-Feistritzer10Maximilian Coen11Bernhard Pfeifer12Verena Rass13Alexander Egger14Gregor Hörmann15Barbara Sperner-Unterweger16Raimund Helbok17Ewald Wöll18Günter Weiss19Gerlig Widmann20Ivan Tancevski21Thomas Sonnweber22Judith Löffler-Ragg23 Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria Department of Radiology, Medical University of Innsbruck, Innsbruck, Austria Department of Psychiatry, Psychotherapy, Psychosomatics and Medical Psychology, University Hospital for Psychiatry II, Medical University of Innsbruck, Innsbruck, Austria Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria Department of Radiology, Medical University of Innsbruck, Innsbruck, Austria Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria Division for Health Networking and Telehealth, Biomedical Informatics and Mechatronics, UMIT, Hall in Tyrol, Austria Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria Central Institute of Medical and Chemical Laboratory Diagnostics, University Hospital Innsbruck, Innsbruck, Austria Central Institute of Medical and Chemical Laboratory Diagnostics, University Hospital Innsbruck, Innsbruck, Austria Department of Psychiatry, Psychotherapy, Psychosomatics and Medical Psychology, University Hospital for Psychiatry II, Medical University of Innsbruck, Innsbruck, Austria Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria Department of Internal Medicine, St Vinzenz Hospital, Zams, Austria Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria Department of Radiology, Medical University of Innsbruck, Innsbruck, Austria Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria Background Recovery trajectories from coronavirus disease 2019 (COVID-19) call for longitudinal investigation. We aimed to characterise the kinetics and status of clinical, cardiopulmonary and mental health recovery up to 1 year following COVID-19. Methods Clinical evaluation, lung function testing (LFT), chest computed tomography (CT) and transthoracic echocardiography were conducted at 2, 3, 6 and 12 months after disease onset. Submaximal exercise capacity, mental health status and quality of life were assessed at 12 months. Recovery kinetics and patterns were investigated by mixed-effect logistic modelling, correlation and clustering analyses. Risk of persistent symptoms and cardiopulmonary abnormalities at the 1-year follow-up were modelled by logistic regression. Findings Out of 145 CovILD study participants, 108 (74.5%) completed the 1-year follow-up (median age 56.5 years; 59.3% male; 24% intensive care unit patients). Comorbidities were present in 75% (n=81). Key outcome measures plateaued after 180 days. At 12 months, persistent symptoms were found in 65% of participants; 33% suffered from LFT impairment; 51% showed CT abnormalities; and 63% had low-grade diastolic dysfunction. Main risk factors for cardiopulmonary impairment included pro-inflammatory and immunological biomarkers at early visits. In addition, we deciphered three recovery clusters separating almost complete recovery from patients with post-acute inflammatory profile and an enrichment in cardiopulmonary residuals from a female-dominated post-COVID-19 syndrome with reduced mental health status. Conclusion 1 year after COVID-19, the burden of persistent symptoms, impaired lung function, radiological abnormalities remains high in our study population. Yet, three recovery trajectories are emerging, ranging from almost complete recovery to post-COVID-19 syndrome with impaired mental health.http://openres.ersjournals.com/content/9/2/00317-2022.full |
| spellingShingle | Sabina Sahanic Piotr Tymoszuk Anna K. Luger Katharina Hüfner Anna Boehm Alex Pizzini Christoph Schwabl Sabine Koppelstätter Katharina Kurz Malte Asshoff Birgit Mosheimer-Feistritzer Maximilian Coen Bernhard Pfeifer Verena Rass Alexander Egger Gregor Hörmann Barbara Sperner-Unterweger Raimund Helbok Ewald Wöll Günter Weiss Gerlig Widmann Ivan Tancevski Thomas Sonnweber Judith Löffler-Ragg COVID-19 and its continuing burden after 12 months: a longitudinal observational prospective multicentre trial ERJ Open Research |
| title | COVID-19 and its continuing burden after 12 months: a longitudinal observational prospective multicentre trial |
| title_full | COVID-19 and its continuing burden after 12 months: a longitudinal observational prospective multicentre trial |
| title_fullStr | COVID-19 and its continuing burden after 12 months: a longitudinal observational prospective multicentre trial |
| title_full_unstemmed | COVID-19 and its continuing burden after 12 months: a longitudinal observational prospective multicentre trial |
| title_short | COVID-19 and its continuing burden after 12 months: a longitudinal observational prospective multicentre trial |
| title_sort | covid 19 and its continuing burden after 12 months a longitudinal observational prospective multicentre trial |
| url | http://openres.ersjournals.com/content/9/2/00317-2022.full |
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