Choice of Antimicrobials in Surgical Prophylaxis - Overuse and Surgical Site Infection Outcomes from a Tertiary-Level Care Hospital
Background: This study was aimed to describe the choice of Surgical Antimicrobial Prophylaxis at a tertiary-level care hospital in United Arab Emirates. It also associated the choice between two leading antimicrobials for the SAP to the site of surgery.Methods: A descriptive drug use evaluation was...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.849044/full |
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| author | Prasanna Vippadapu Syed Wasif Gillani Dixon Thomas Fiaz Ahmed Shabaz Mohiuddin Gulam Shabaz Mohiuddin Gulam Rana Kamran Mahmood Rana Kamran Mahmood Vineetha Menon Semira Abdi Semira Abdi Hassaan Anwer Rathore |
| author_facet | Prasanna Vippadapu Syed Wasif Gillani Dixon Thomas Fiaz Ahmed Shabaz Mohiuddin Gulam Shabaz Mohiuddin Gulam Rana Kamran Mahmood Rana Kamran Mahmood Vineetha Menon Semira Abdi Semira Abdi Hassaan Anwer Rathore |
| author_sort | Prasanna Vippadapu |
| collection | DOAJ |
| description | Background: This study was aimed to describe the choice of Surgical Antimicrobial Prophylaxis at a tertiary-level care hospital in United Arab Emirates. It also associated the choice between two leading antimicrobials for the SAP to the site of surgery.Methods: A descriptive drug use evaluation was performed retrospectively to study choices of antimicrobials in surgical antibiotic prophylaxis. An analytical cross-sectional study design was used to develop a hypothesis regarding the choice of ceftriaxone. Data were collected from the medical records of Hospital from July 2020 to December 2020. Results were presented in numbers and percentages.Results: SAP data were collected from 199 patients, of which 159 were clean or clean-contaminated. Dirty surgeries (18) needed a higher level of antimicrobials as there were infections to be treated. For other surgeries with no infection, overuse of antimicrobials was found regarding the choice of antimicrobials. Surgical antibiotic Prophylaxis was administered within the recommended time prior to surgeries. Ceftriaxone was preferred over cefuroxime in all types of surgeries based on the timing of Surgical Antibiotic Prophylaxis, wound classification, and the surgical site. A statistically significant association for choice of ceftriaxone over cefuroxime was found regarding surgical sites (p-value <0.05). About 99% of the patients were prescribed discharge antimicrobials when 158 (80%) surgeries were clean or clean-contaminated.Conclusion: Overuse of antimicrobials was found in surgical antimicrobial prophylaxis. Ceftriaxone was preferred more than cefuroxime in all types of surgeries. No surgical site infections were reported. A follow-up comparative study is recommended to decrease antimicrobial use without increasing risk of surgical site infection. |
| first_indexed | 2024-12-10T13:13:07Z |
| format | Article |
| id | doaj.art-6082d7cdfe9b4bc9b2a38f74290cc337 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-10T13:13:07Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Pharmacology |
| spelling | doaj.art-6082d7cdfe9b4bc9b2a38f74290cc3372022-12-22T01:47:36ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-04-011310.3389/fphar.2022.849044849044Choice of Antimicrobials in Surgical Prophylaxis - Overuse and Surgical Site Infection Outcomes from a Tertiary-Level Care HospitalPrasanna Vippadapu0Syed Wasif Gillani1Dixon Thomas2Fiaz Ahmed3Shabaz Mohiuddin Gulam4Shabaz Mohiuddin Gulam5Rana Kamran Mahmood6Rana Kamran Mahmood7Vineetha Menon8Semira Abdi9Semira Abdi10Hassaan Anwer Rathore11College of Pharmacy, Gulf Medical University, Ajman, United Arab EmiratesCollege of Pharmacy, Gulf Medical University, Ajman, United Arab EmiratesCollege of Pharmacy, Gulf Medical University, Ajman, United Arab EmiratesThumbay University Hospital, Ajman, United Arab EmiratesCollege of Pharmacy, Gulf Medical University, Ajman, United Arab EmiratesThumbay University Hospital, Ajman, United Arab EmiratesCollege of Pharmacy, Gulf Medical University, Ajman, United Arab EmiratesResponsePlus Medical, Abu Dhabi, United Arab EmiratesCollege of Pharmacy, Gulf Medical University, Ajman, United Arab EmiratesCollege of Pharmacy, Gulf Medical University, Ajman, United Arab EmiratesDubai Pharmacy College, Dubai, United Arab EmiratesCollege of Pharmacy, Qatar University, Doha, QatarBackground: This study was aimed to describe the choice of Surgical Antimicrobial Prophylaxis at a tertiary-level care hospital in United Arab Emirates. It also associated the choice between two leading antimicrobials for the SAP to the site of surgery.Methods: A descriptive drug use evaluation was performed retrospectively to study choices of antimicrobials in surgical antibiotic prophylaxis. An analytical cross-sectional study design was used to develop a hypothesis regarding the choice of ceftriaxone. Data were collected from the medical records of Hospital from July 2020 to December 2020. Results were presented in numbers and percentages.Results: SAP data were collected from 199 patients, of which 159 were clean or clean-contaminated. Dirty surgeries (18) needed a higher level of antimicrobials as there were infections to be treated. For other surgeries with no infection, overuse of antimicrobials was found regarding the choice of antimicrobials. Surgical antibiotic Prophylaxis was administered within the recommended time prior to surgeries. Ceftriaxone was preferred over cefuroxime in all types of surgeries based on the timing of Surgical Antibiotic Prophylaxis, wound classification, and the surgical site. A statistically significant association for choice of ceftriaxone over cefuroxime was found regarding surgical sites (p-value <0.05). About 99% of the patients were prescribed discharge antimicrobials when 158 (80%) surgeries were clean or clean-contaminated.Conclusion: Overuse of antimicrobials was found in surgical antimicrobial prophylaxis. Ceftriaxone was preferred more than cefuroxime in all types of surgeries. No surgical site infections were reported. A follow-up comparative study is recommended to decrease antimicrobial use without increasing risk of surgical site infection.https://www.frontiersin.org/articles/10.3389/fphar.2022.849044/fullsurgical antimicrobial prophylaxisceftriaxonecefotaximesurgeriessurgical site infectionsantimicrobial stewardship |
| spellingShingle | Prasanna Vippadapu Syed Wasif Gillani Dixon Thomas Fiaz Ahmed Shabaz Mohiuddin Gulam Shabaz Mohiuddin Gulam Rana Kamran Mahmood Rana Kamran Mahmood Vineetha Menon Semira Abdi Semira Abdi Hassaan Anwer Rathore Choice of Antimicrobials in Surgical Prophylaxis - Overuse and Surgical Site Infection Outcomes from a Tertiary-Level Care Hospital Frontiers in Pharmacology surgical antimicrobial prophylaxis ceftriaxone cefotaxime surgeries surgical site infections antimicrobial stewardship |
| title | Choice of Antimicrobials in Surgical Prophylaxis - Overuse and Surgical Site Infection Outcomes from a Tertiary-Level Care Hospital |
| title_full | Choice of Antimicrobials in Surgical Prophylaxis - Overuse and Surgical Site Infection Outcomes from a Tertiary-Level Care Hospital |
| title_fullStr | Choice of Antimicrobials in Surgical Prophylaxis - Overuse and Surgical Site Infection Outcomes from a Tertiary-Level Care Hospital |
| title_full_unstemmed | Choice of Antimicrobials in Surgical Prophylaxis - Overuse and Surgical Site Infection Outcomes from a Tertiary-Level Care Hospital |
| title_short | Choice of Antimicrobials in Surgical Prophylaxis - Overuse and Surgical Site Infection Outcomes from a Tertiary-Level Care Hospital |
| title_sort | choice of antimicrobials in surgical prophylaxis overuse and surgical site infection outcomes from a tertiary level care hospital |
| topic | surgical antimicrobial prophylaxis ceftriaxone cefotaxime surgeries surgical site infections antimicrobial stewardship |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.849044/full |
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