Stacking the odds for Golgi cisternal maturation
What is the minimal set of cell-biological ingredients needed to generate a Golgi apparatus? The compositions of eukaryotic organelles arise through a process of molecular exchange via vesicle traffic. Here we statistically sample tens of thousands of homeostatic vesicle traffic networks generated b...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2016-08-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/16231 |
| _version_ | 1811200359256817664 |
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| author | Somya Mani Mukund Thattai |
| author_facet | Somya Mani Mukund Thattai |
| author_sort | Somya Mani |
| collection | DOAJ |
| description | What is the minimal set of cell-biological ingredients needed to generate a Golgi apparatus? The compositions of eukaryotic organelles arise through a process of molecular exchange via vesicle traffic. Here we statistically sample tens of thousands of homeostatic vesicle traffic networks generated by realistic molecular rules governing vesicle budding and fusion. Remarkably, the plurality of these networks contain chains of compartments that undergo creation, compositional maturation, and dissipation, coupled by molecular recycling along retrograde vesicles. This motif precisely matches the cisternal maturation model of the Golgi, which was developed to explain many observed aspects of the eukaryotic secretory pathway. In our analysis cisternal maturation is a robust consequence of vesicle traffic homeostasis, independent of the underlying details of molecular interactions or spatial stacking. This architecture may have been exapted rather than selected for its role in the secretion of large cargo. |
| first_indexed | 2024-04-12T02:03:31Z |
| format | Article |
| id | doaj.art-608360d3cdcd4868af087e4ee1d7b09d |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T02:03:31Z |
| publishDate | 2016-08-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-608360d3cdcd4868af087e4ee1d7b09d2022-12-22T03:52:36ZengeLife Sciences Publications LtdeLife2050-084X2016-08-01510.7554/eLife.16231Stacking the odds for Golgi cisternal maturationSomya Mani0Mukund Thattai1https://orcid.org/0000-0002-2558-6517Simons Centre for the Study of Living Machines, National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore, IndiaSimons Centre for the Study of Living Machines, National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore, IndiaWhat is the minimal set of cell-biological ingredients needed to generate a Golgi apparatus? The compositions of eukaryotic organelles arise through a process of molecular exchange via vesicle traffic. Here we statistically sample tens of thousands of homeostatic vesicle traffic networks generated by realistic molecular rules governing vesicle budding and fusion. Remarkably, the plurality of these networks contain chains of compartments that undergo creation, compositional maturation, and dissipation, coupled by molecular recycling along retrograde vesicles. This motif precisely matches the cisternal maturation model of the Golgi, which was developed to explain many observed aspects of the eukaryotic secretory pathway. In our analysis cisternal maturation is a robust consequence of vesicle traffic homeostasis, independent of the underlying details of molecular interactions or spatial stacking. This architecture may have been exapted rather than selected for its role in the secretion of large cargo.https://elifesciences.org/articles/16231Golgi apparatuscisternal maturationvesicle trafficBoolean modelsstatistical cell biology |
| spellingShingle | Somya Mani Mukund Thattai Stacking the odds for Golgi cisternal maturation eLife Golgi apparatus cisternal maturation vesicle traffic Boolean models statistical cell biology |
| title | Stacking the odds for Golgi cisternal maturation |
| title_full | Stacking the odds for Golgi cisternal maturation |
| title_fullStr | Stacking the odds for Golgi cisternal maturation |
| title_full_unstemmed | Stacking the odds for Golgi cisternal maturation |
| title_short | Stacking the odds for Golgi cisternal maturation |
| title_sort | stacking the odds for golgi cisternal maturation |
| topic | Golgi apparatus cisternal maturation vesicle traffic Boolean models statistical cell biology |
| url | https://elifesciences.org/articles/16231 |
| work_keys_str_mv | AT somyamani stackingtheoddsforgolgicisternalmaturation AT mukundthattai stackingtheoddsforgolgicisternalmaturation |