Ketone Monoester Followed by Carbohydrate Ingestion after Glycogen-Lowering Exercise Does Not Improve Subsequent Endurance Cycle Time Trial Performance
Relative to carbohydrate (CHO) alone, exogenous ketones followed by CHO supplementation during recovery from glycogen-lowering exercise have been shown to increase muscle glycogen resynthesis. However, whether this strategy improves subsequent exercise performance is unknown. The objective of this s...
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MDPI AG
2024-03-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/16/7/932 |
| _version_ | 1797212154317766656 |
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| author | Manuel D. Quinones Kyle Weiman Peter W. R. Lemon |
| author_facet | Manuel D. Quinones Kyle Weiman Peter W. R. Lemon |
| author_sort | Manuel D. Quinones |
| collection | DOAJ |
| description | Relative to carbohydrate (CHO) alone, exogenous ketones followed by CHO supplementation during recovery from glycogen-lowering exercise have been shown to increase muscle glycogen resynthesis. However, whether this strategy improves subsequent exercise performance is unknown. The objective of this study was to assess the efficacy of ketone monoester (KME) followed by CHO ingestion after glycogen-lowering exercise on subsequent 20 km (TT<sub>20km</sub>) and 5 km (TT<sub>5km</sub>) best-effort time trials. Nine recreationally active men (175.6 ± 5.3 cm, 72.9 ± 7.7 kg, 28 ± 5 y, 12.2 ± 3.2% body fat, VO<sub>2</sub>max = 56.2 ± 5.8 mL· kg BM<sup>−1</sup>·min<sup>−1</sup>; mean ± SD) completed a glycogen-lowering exercise session, followed by 4 h of recovery and subsequent TT<sub>20km</sub> and TT<sub>5km</sub>. During the first 2 h of recovery, participants ingested either KME (25 g) followed by CHO at a rate of 1.2 g·kg<sup>−1</sup>·h<sup>−1</sup> (KME + CHO) or an iso-energetic placebo (dextrose) followed by CHO (PLAC + CHO). Blood metabolites during recovery and performance during the subsequent two-time trials were measured. In comparison to PLAC + CHO, KME + CHO displayed greater (<i>p</i> < 0.05) blood beta-hydroxybutyrate concentration during the first 2 h, lower (<i>p</i> < 0.05) blood glucose concentrations at 30 and 60 min, as well as greater (<i>p</i> < 0.05) blood insulin concentration 2 h following ingestion. However, no treatment differences (<i>p</i> > 0.05) in power output nor time to complete either time trial were observed vs. PLAC + CHO. These data indicate that the metabolic changes induced by KME + CHO ingestion following glycogen-lowering exercise are insufficient to enhance subsequent endurance time trial performance. |
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| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-04-24T10:37:52Z |
| publishDate | 2024-03-01 |
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| series | Nutrients |
| spelling | doaj.art-6083983748b74c7c98c37c303a5efa612024-04-12T13:24:09ZengMDPI AGNutrients2072-66432024-03-0116793210.3390/nu16070932Ketone Monoester Followed by Carbohydrate Ingestion after Glycogen-Lowering Exercise Does Not Improve Subsequent Endurance Cycle Time Trial PerformanceManuel D. Quinones0Kyle Weiman1Peter W. R. Lemon2Exercise Nutrition Research Laboratory, School of Kinesiology, The University of Western Ontario, London, ON N6A 3K7, CanadaExercise Nutrition Research Laboratory, School of Kinesiology, The University of Western Ontario, London, ON N6A 3K7, CanadaExercise Nutrition Research Laboratory, School of Kinesiology, The University of Western Ontario, London, ON N6A 3K7, CanadaRelative to carbohydrate (CHO) alone, exogenous ketones followed by CHO supplementation during recovery from glycogen-lowering exercise have been shown to increase muscle glycogen resynthesis. However, whether this strategy improves subsequent exercise performance is unknown. The objective of this study was to assess the efficacy of ketone monoester (KME) followed by CHO ingestion after glycogen-lowering exercise on subsequent 20 km (TT<sub>20km</sub>) and 5 km (TT<sub>5km</sub>) best-effort time trials. Nine recreationally active men (175.6 ± 5.3 cm, 72.9 ± 7.7 kg, 28 ± 5 y, 12.2 ± 3.2% body fat, VO<sub>2</sub>max = 56.2 ± 5.8 mL· kg BM<sup>−1</sup>·min<sup>−1</sup>; mean ± SD) completed a glycogen-lowering exercise session, followed by 4 h of recovery and subsequent TT<sub>20km</sub> and TT<sub>5km</sub>. During the first 2 h of recovery, participants ingested either KME (25 g) followed by CHO at a rate of 1.2 g·kg<sup>−1</sup>·h<sup>−1</sup> (KME + CHO) or an iso-energetic placebo (dextrose) followed by CHO (PLAC + CHO). Blood metabolites during recovery and performance during the subsequent two-time trials were measured. In comparison to PLAC + CHO, KME + CHO displayed greater (<i>p</i> < 0.05) blood beta-hydroxybutyrate concentration during the first 2 h, lower (<i>p</i> < 0.05) blood glucose concentrations at 30 and 60 min, as well as greater (<i>p</i> < 0.05) blood insulin concentration 2 h following ingestion. However, no treatment differences (<i>p</i> > 0.05) in power output nor time to complete either time trial were observed vs. PLAC + CHO. These data indicate that the metabolic changes induced by KME + CHO ingestion following glycogen-lowering exercise are insufficient to enhance subsequent endurance time trial performance.https://www.mdpi.com/2072-6643/16/7/932exogenous ketonesketosisglycogen repletionexercise recoveryinsulin |
| spellingShingle | Manuel D. Quinones Kyle Weiman Peter W. R. Lemon Ketone Monoester Followed by Carbohydrate Ingestion after Glycogen-Lowering Exercise Does Not Improve Subsequent Endurance Cycle Time Trial Performance Nutrients exogenous ketones ketosis glycogen repletion exercise recovery insulin |
| title | Ketone Monoester Followed by Carbohydrate Ingestion after Glycogen-Lowering Exercise Does Not Improve Subsequent Endurance Cycle Time Trial Performance |
| title_full | Ketone Monoester Followed by Carbohydrate Ingestion after Glycogen-Lowering Exercise Does Not Improve Subsequent Endurance Cycle Time Trial Performance |
| title_fullStr | Ketone Monoester Followed by Carbohydrate Ingestion after Glycogen-Lowering Exercise Does Not Improve Subsequent Endurance Cycle Time Trial Performance |
| title_full_unstemmed | Ketone Monoester Followed by Carbohydrate Ingestion after Glycogen-Lowering Exercise Does Not Improve Subsequent Endurance Cycle Time Trial Performance |
| title_short | Ketone Monoester Followed by Carbohydrate Ingestion after Glycogen-Lowering Exercise Does Not Improve Subsequent Endurance Cycle Time Trial Performance |
| title_sort | ketone monoester followed by carbohydrate ingestion after glycogen lowering exercise does not improve subsequent endurance cycle time trial performance |
| topic | exogenous ketones ketosis glycogen repletion exercise recovery insulin |
| url | https://www.mdpi.com/2072-6643/16/7/932 |
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